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Anti-DPP4/CD26 Antibody (6M894)
还可以产品编号 TMAY-01062
Anti-DPP4/CD26 Antibody (6M894) 是一种 Mouse 抗体，靶向 DPP4/CD26。Anti-DPP4/CD26 Antibody (6M894) 可用于 FCM。
Anti-DPP4/CD26 Antibody (6M894)
Anti-DPP4/CD26 Antibody (6M894)
还可以产品编号 TMAY-01062
Anti-DPP4/CD26 Antibody (6M894) 是一种 Mouse 抗体，靶向 DPP4/CD26。Anti-DPP4/CD26 Antibody (6M894) 可用于 FCM。
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偶联与修饰
抗原信息
| 产品描述 | Anti-DPP4/CD26 Antibody (6M894) is a Mouse antibody targeting DPP4/CD26. Anti-DPP4/CD26 Antibody (6M894) can be used in FCM. |
| Ig Type | Monoclonal Mouse IgG1 |
| 克隆号 | 6M894 |
| 交叉反应 | Human |
| 验证活性 | Flow cytometric analysis of Human CD26(DPP4) expression on human whole blood lymphocytes. Cells were stained with purified anti-Human CD26(DPP4), then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of viable lymphocytes. |
| 应用 | FCM |
| 推荐剂量 | FCM: 1:25-1:100 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human DPP4 / CD26 (rh DPP4 / CD26; TMPY-00779; NP_001926.2; Asn29-Pro766). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | Dipeptidyl peptidase-4 (DPP4) or adenosine deaminase complexing protein 2 (ADCP 2) or T-cell activation antigen CD26 is a serine exopeptidase belonging to the S9B protein family that cleaves X-proline dipeptides from the N-terminus of polypeptides, such as chemokines, neuropeptides, and peptide hormones. The enzyme is a type II transmembrane glycoprotein, expressed on the surface of many cell types. It is also present in serum and other body fluids in a truncated form (sCD26/DPPIV). The soluble CD26 (sCD26) as a tumour marker for the detection of colorectal cancer (CRC) and advanced adenomas. As both a regulatory enzyme and a signalling factor, DPP4 has been evaluated and described in many studies. DPP4 inhibition results in increased blood concentration of the incretin hormones glucagon-like peptide-1 (GLP-1) and gastric inhibitory polypeptide (GIP). This causes an increase in glucose-dependent stimulation, resulting in a lowering of blood glucose levels. Recent studies have shown that DPP4 inhibitors can induce a significant reduction in glycosylated haemoglobin (HbA(1c)) levels, either as monotherapy or as a combination with other antidiabetic agents. Research has also demonstrated that DPP4 inhibitors portray a very low risk of hypoglycaemia development, and are a new pharmacological class of drugs for treating Type 2 diabetes. |
| 偶联 | Unconjugated |
| 其他可选修饰符 | APC/FITC/PE |
| 可提供抗体种类 | 4 |
| 免疫原 | Recombinant Human DPP4 / CD26 Protein (TMPY-00779) |
| 抗原种属 | Human |
| 研究领域 | Serine Proteases and Regulators |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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