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Anti-DKK2 Antibody (3L558) 是一种 Mouse 抗体,靶向 DKK2。Anti-DKK2 Antibody (3L558) 可用于 WB。
Anti-DKK2 Antibody (3L558) 是一种 Mouse 抗体,靶向 DKK2。Anti-DKK2 Antibody (3L558) 可用于 WB。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,170 | 5日内发货 | |
| 100 μL | ¥ 1,965 | 5日内发货 |
| 产品描述 | Anti-DKK2 Antibody (3L558) is a Mouse antibody targeting DKK2. Anti-DKK2 Antibody (3L558) can be used in WB. |
| Ig Type | IgG1, k |
| 克隆号 | 3L558 |
| 反应种属 | Human,Mouse |
| 应用 | WB |
| 推荐剂量 | WB: 1:500-1000 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 亚细胞定位 | Secreted. |
| 组织特异性 | Expressed in heart, brain, skeletal muscle and lung. |
| 构建方式 | Hybridoma Monoclonal Antibody |
| 纯化方式 | Protein G purified |
| 性状 | Liquid |
| 缓冲液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 浓度 | 1mg/ml |
| 研究背景 | This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. It can act as either an agonist or antagonist of Wnt/beta-catenin signaling, depending on the cellular context and the presence of the co-factor kremen 2. Activity of this protein is also modulated by binding to the Wnt co-receptor LDL-receptor related protein 6 (LRP6). [provided by RefSeq, Jul 2008] |
| 免疫原 | Recombinant Protein: human DKK2 |
| 抗原种属 | Human |
| 基因名称 | DKK2 |
| 基因ID | |
| 蛋白名称 | Dickkopf-related protein 2 |
| Uniprot ID | |
| 功能 | Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. |
| 分子量 | Theoretical: 25 kDa. |
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
| 存储 | store at low temperature | -20°C for 1 year |