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顶部生物活性储存和溶解信息计算器

Anti-DKK1 Antibody (8S801)

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Anti-DKK1 Antibody (8S801)
产品编号 TMAC-01151
别名 SK, hDkk-1, hDkk1, Dkk-1, Dkk1, Dickkopf-related 1, Dickkopf-1

Anti-DKK1 Antibody (8S801) 是一种 Rabbit 抗体，靶向 DKK1。Anti-DKK1 Antibody (8S801) 可用于 WB,ICC/IF,IHC,FCM。

Anti-DKK1 Antibody (8S801)

Anti-DKK1 Antibody (8S801)

Rating icon 还可以
Anti-DKK1 Antibody (8S801)
产品编号 TMAC-01151 别名 SK, hDkk-1, hDkk1, Dkk-1, Dkk1, Dickkopf-related 1, Dickkopf-1

Anti-DKK1 Antibody (8S801) 是一种 Rabbit 抗体，靶向 DKK1。Anti-DKK1 Antibody (8S801) 可用于 WB,ICC/IF,IHC,FCM。

规格价格库存数量
50 μL
¥ 1,480
5日内发货
100 μL
¥ 2,495
5日内发货
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产品介绍

生物活性
产品描述
Anti-DKK1 Antibody (8S801) is a Rabbit antibody targeting DKK1. Anti-DKK1 Antibody (8S801) can be used in WB,ICC/IF,IHC,FCM.
别名SK, hDkk-1, hDkk1, Dkk-1, Dkk1, Dickkopf-related 1, Dickkopf-1
Ig Type
IgG
交叉反应
Human,Rat
验证活性
1. Western blot analysis of DKK1 on MCF-7 cells lysates using anti-DKK1 antibody at 1/1,000 dilution.
2. Immunohistochemical analysis of paraffin-embedded human uterus tissue using anti-DKK1 antibody. Counter stained with hematoxylin.
3. ICC staining DKK1 in Hela cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
4. ICC staining DKK1 in HepG2 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
5. ICC staining DKK1 in NCCIT cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
6. Flow cytometric analysis of Hela cells with DKK1 antibody at 1/50 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black). Alexa Fluor 488-conjugated goat anti rabbit IgG was used as the secondary antibody.
应用
WB
ICC/IF
IHC
FCM
推荐剂量
WB: 1:1000; IHC: 1:50-200; ICC/IF: 1:50-500; FCM: 1:50-100
抗体种类
Monoclonal
宿主来源Rabbit
构建方式Recombinant Antibody
纯化方式ProA affinity purified
性状Liquid
缓冲液1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
研究背景The Wnt genes are a group of well conserved, cysteine-rich secreted glycoproteins that are required for numerous developmental processes including embryogenesis, asymmetric cell division and central nervous system (CNS) patterning. Wnt association with the seven membrane spanning receptor frizzled activates dishevelled, which downregulates glycogen synthase kinase (GSK) through serine phosphorylation, causing the accumulation of b-catenin and subsequent regulation of developmentally significant Wnt |target genes. The Dickkopf family of secreted inhibitors of Wnt signaling ensures proper morphological development by antagonizing different stages of the Wnt cascade. Dkk-1 (Dickkopf-1) acts upstream of b-catenin and dishevelled to inhibit Wnt signaling. Dkk-1 is a 266-amino acid (human), secreted protein that contains a 31-residue N-terminal signal peptide, 2 cysteine rich domains, and a putative carboxy terminal N-glycosylation site. Human Dkk-1 transcripts are abundantly present in fetal kidney, adult placenta and adult prostate. Putative cis regulatory elements upstream of the Dkk-1 start site include p53, Sp1, MyoD, STAT, Oct-1/2, C/EBP-a, C/EBP-b, GATA-1, GATA-2 and GATA-3.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
Recombinant Protein
Uniprot ID
O94907
化学信息
分子量Theoretical: 38 kDa.
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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