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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-DHFR Polyclonal Antibody

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货号 TMAB-05123

Anti-DHFR Polyclonal Antibody 是一种 Rabbit 抗体，靶向 DHFR。Anti-DHFR Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。

Anti-DHFR Polyclonal Antibody

Anti-DHFR Polyclonal Antibody

一键复制产品信息
Rating icon 还可以
货号 TMAB-05123

Anti-DHFR Polyclonal Antibody 是一种 Rabbit 抗体，靶向 DHFR。Anti-DHFR Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。

规格价格库存数量
50 μL
¥ 1,160
5日内发货
100 μL
¥ 1,970
5日内发货
200 μL
¥ 2,795
5日内发货
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产品介绍

生物活性
产品描述
Anti-DHFR Polyclonal Antibody is a Rabbit antibody targeting DHFR. Anti-DHFR Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Ig Type
IgG
反应种属
Human,Mouse
应用IHC-PIHC-FrIF
推荐剂量
IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:50-200
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Isoform Alpha: Mitochondrion membrane; Single-pass membrane protein. Cytoplasm.
组织特异性Widely expressed in fetal and adult tissues, including throughout the fetal and adult brains and whole blood. Expression is higher in the adult brain than in the fetal brain.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景DHFR catalyzes the NADPH-dependent reduction of dihydrofolate to tetrahydrofolate, and is a crucial enzyme for the synthesis of purines, pyrimidines and some amino acids. Inhibition of the activity of this enzyme leads to arrest of DNA synthesis and cell death. Gene expression of methotrexate (MTX)-resistant variants of DHFR in normal hematopoietic cells is a potential strategy to permit administration of larger doses of MTX by alleviating drug toxicity in normal cells and tissues that are drug sensitive.
抗原信息
免疫原
KLH conjugated synthetic peptide: human DHFR
抗原种属
Human
基因名称
DHFR
基因ID
1719
蛋白名称
Dihydrofolate reductase
Uniprot ID
P00374
功能
Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFRL1.
化学信息
分子量Theoretical: 21 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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