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Anti-DDB2 Antibody (1O273)
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产品编号 TMAC-01126
别名 UV-DDB 2, UV-damaged DNA-binding protein 2, DNA damage-binding protein 2, DDBb, DDB p48 subunit, DDB 2, Damage-specific DNA-binding protein 2
Anti-DDB2 Antibody (1O273) 是一种 Rabbit 抗体，靶向 DDB2。Anti-DDB2 Antibody (1O273) 可用于 WB,IHC,FCM。
Anti-DDB2 Antibody (1O273)
Anti-DDB2 Antibody (1O273)
还可以产品编号 TMAC-01126 别名 UV-DDB 2, UV-damaged DNA-binding protein 2, DNA damage-binding protein 2, DDBb, DDB p48 subunit, DDB 2, Damage-specific DNA-binding protein 2
Anti-DDB2 Antibody (1O273) 是一种 Rabbit 抗体，靶向 DDB2。Anti-DDB2 Antibody (1O273) 可用于 WB,IHC,FCM。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,485 | 5日内发货 | |
| 100 μL | ¥ 2,485 | 5日内发货 |
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产品介绍
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抗原信息
化学信息
| 产品描述 | Anti-DDB2 Antibody (1O273) is a Rabbit antibody targeting DDB2. Anti-DDB2 Antibody (1O273) can be used in WB,IHC,FCM. |
| 别名 | UV-DDB 2, UV-damaged DNA-binding protein 2, DNA damage-binding protein 2, DDBb, DDB p48 subunit, DDB 2, Damage-specific DNA-binding protein 2 |
| Ig Type | IgG |
| 交叉反应 | Human |
| 验证活性 | 1. Western blot analysis of DDB2 on Daudi cell using anti-DDB2 antibody at 1/1,000 dilution. 2. Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-DDB2 antibody. Counter stained with hematoxylin. 3. Immunohistochemical analysis of paraffin-embedded human liver cancer tissue using anti-DDB2 antibody. Counter stained with hematoxylin. 4. Immunohistochemical analysis of paraffin-embedded human skin tissue using anti-DDB2 antibody. Counter stained with hematoxylin. 5. Flow cytometric analysis of A549 cells with DDB2 antibody at 1/100 dilution (purple) compared with an unlabelled control (cells without incubation with primary antibody; yellow). Alexa Fluor 488-conjugated goat anti-rabbit IgG was used as the secondary antibody. |
| 应用 | |
| 推荐剂量 | WB: 1:500-2000; IHC: 1:50-200; FCM: 1:50-100 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | Recombinant Antibody |
| 纯化方式 | ProA affinity purified |
| 性状 | Liquid |
| 缓冲液 | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| 研究背景 | Damaged DNA binding protein (DDB) is a heterodimer composed of two subunits, p127 and p48, which are designated DDB1 and DDB2, respectively. The DDB heterodimer is involved in repairing DNA damaged by ultraviolet light. Specifically, DDB, also designated UV-damaged DNA binding protein (UV-DDB), xeroderma pigmentosum group E binding factor (XPE-BF) and hepatitis B virus X-associated protein 1 (XAP-1), binds to damaged cyclobutane pyrimidine dimers (CPDs). Mutations in the DDB2 gene are implicated as causes of xeroderma pigmentosum group E, an autosomal recessive disease in which patients are defective in nucleotide excision DNA repair. XPE is characterized by hypersensitivity of the skin to sunlight with a high frequency of skin cancer as well as neurologic abnormalities. The hepatitis B virus (HBV) X protein interacts with DDB1, which may mediate HBx transactivation. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Protein: C-terminal human DDB2 |
| 抗原种属 | human |
| Uniprot ID |
| 分子量 | Theoretical: 48 kDa. |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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