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Anti-DC-SIGN Antibody (7H439)

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Anti-DC-SIGN Antibody (7H439)
产品编号 TMAY-00446
别名 DC-SIGN, CD209 molecule, CD209

Anti-DC-SIGN Antibody (7H439) 是一种 Rabbit 抗体，靶向 DC-SIGN。Anti-DC-SIGN Antibody (7H439) 可用于 FCM。

Anti-DC-SIGN Antibody (7H439)
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Anti-DC-SIGN Antibody (7H439)

Rating icon 还可以
Anti-DC-SIGN Antibody (7H439)
产品编号 TMAY-00446 别名 DC-SIGN, CD209 molecule, CD209

Anti-DC-SIGN Antibody (7H439) 是一种 Rabbit 抗体，靶向 DC-SIGN。Anti-DC-SIGN Antibody (7H439) 可用于 FCM。

规格价格库存数量
100 μL
¥ 2,279
5日内发货
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产品介绍

生物活性
产品描述
Anti-DC-SIGN Antibody (7H439) is a Rabbit antibody targeting DC-SIGN. Anti-DC-SIGN Antibody (7H439) can be used in FCM.
别名DC-SIGN, CD209 molecule, CD209
Ig Type
Rabbit IgG
克隆号
7H439
交叉反应
Human
验证活性
Flow cytometric analysis of Human CD209 expression on DC. Cells were stained with purified anti-Human CD209, then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells.
应用
FCM
推荐剂量
FCM: 1:25-1:100
抗体种类
Monoclonal
宿主来源Rabbit
构建方式This antibody was obtained from a rabbit immunized with purified, recombinant Human CD209/DC-SIGN (rh CD209/DC-SIGN; TMPY-00772; NP_066978.1; Lys62-Ala404).
纯化方式Protein A
性状Liquid
缓冲液0.2 μm filtered solution in PBS
研究背景Dendritic cell (DC)-specific intercellular adhesion molecule 3 (ICAM-3) grabbing nonintegrin (DC-SIGN), also known as CD209, is a type II transmembrane protein on DCs with a C-type lectin extracellular domain, is capable of binding ICAM-3 on resting T cells in the secondary lymphoid organs, providing the initial contact between these cells during the establishment of cell-mediated immunity. It is not only a pattern recognition receptor but implicated in immunoregulation of DCs. It has an important role in mediating DC adhesion, migration, inflammation, activating primary T cell, triggering immune response and participating in immune escape of pathogens and tumors. DC-SIGN also mediates the capture and internalization of viral, bacterial, and fungal pathogens by dendritic cells, such as HIV-1, Ebola virus, cytomegalovirus, Dengue virus, and hepatitis C virus. DC-SIGN is unique in that it regulates adhesion processes, such as DC trafficking and T-cell synapse formation, as well as antigen capture. Moreover, even though several C-type lectins have been shown to bind HIV-1, DC-SIGN does not only capture HIV-1 but also protects it in early endosomes allowing HIV-1 transport by DC to lymphoid tissues, where it enhances trans infection of T cells.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy
偶联与修饰
偶联
Unconjugated
其他可选修饰符
APC/FITC/PE
可提供抗体种类
4
抗原信息
免疫原
Recombinant Protein: Human CD209/DC-SIGN Protein (TMPY-00772)
抗原种属
Human
存储&运输
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
运输方式Shipping with blue ice.

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关键词

CD-209CD 209

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4个月前
5.0
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