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Anti-DC-SIGN Antibody (7H439)
还可以产品编号 TMAY-00446
Anti-DC-SIGN Antibody (7H439) 是一种 Rabbit 抗体，靶向 DC-SIGN。Anti-DC-SIGN Antibody (7H439) 可用于 FCM。
Anti-DC-SIGN Antibody (7H439)
Anti-DC-SIGN Antibody (7H439)
还可以产品编号 TMAY-00446
Anti-DC-SIGN Antibody (7H439) 是一种 Rabbit 抗体，靶向 DC-SIGN。Anti-DC-SIGN Antibody (7H439) 可用于 FCM。
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-DC-SIGN Antibody (7H439) is a Rabbit antibody targeting DC-SIGN. Anti-DC-SIGN Antibody (7H439) can be used in FCM. |
| Ig Type | Monoclonal Rabbit IgG |
| 克隆号 | 7H439 |
| 交叉反应 | Human |
| 验证活性 | Flow cytometric analysis of Human CD209 expression on DC. Cells were stained with purified anti-Human CD209, then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells. |
| 应用 | FCM |
| 推荐剂量 | FCM: 1:25-1:100 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | This antibody was obtained from a rabbit immunized with purified, recombinant Human CD209/DC-SIGN (rh CD209/DC-SIGN; TMPY-00772; NP_066978.1; Lys62-Ala404). |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | Dendritic cell (DC)-specific intercellular adhesion molecule 3 (ICAM-3) grabbing nonintegrin (DC-SIGN), also known as CD209, is a type II transmembrane protein on DCs with a C-type lectin extracellular domain, is capable of binding ICAM-3 on resting T cells in the secondary lymphoid organs, providing the initial contact between these cells during the establishment of cell-mediated immunity. It is not only a pattern recognition receptor but implicated in immunoregulation of DCs. It has an important role in mediating DC adhesion, migration, inflammation, activating primary T cell, triggering immune response and participating in immune escape of pathogens and tumors. DC-SIGN also mediates the capture and internalization of viral, bacterial, and fungal pathogens by dendritic cells, such as HIV-1, Ebola virus, cytomegalovirus, Dengue virus, and hepatitis C virus. DC-SIGN is unique in that it regulates adhesion processes, such as DC trafficking and T-cell synapse formation, as well as antigen capture. Moreover, even though several C-type lectins have been shown to bind HIV-1, DC-SIGN does not only capture HIV-1 but also protects it in early endosomes allowing HIV-1 transport by DC to lymphoid tissues, where it enhances trans infection of T cells.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
| 偶联 | Unconjugated |
| 其他可选修饰符 | APC/FITC/PE |
| 可提供抗体种类 | 4 |
| 免疫原 | Recombinant Human CD209/DC-SIGN Protein (TMPY-00772) |
| 抗原种属 | Human |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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计算器
比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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