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Anti-DAXX Antibody (9O762)
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产品编号 TMAC-01118
别名 MGC126246, MGC126245, hDaxx, Fas death domain associated protein, Fas binding protein, ETS1 associated protein 1, EAP1, EAP 1, Death domain associated protein 6, Death associated protein 6, DAP6, DAP 6, CENP-C binding protein, BING2, BING 2
Anti-DAXX Antibody (9O762) 是一种 Rabbit 抗体，靶向 DAXX。Anti-DAXX Antibody (9O762) 可用于 WB,ICC,FCM。
Anti-DAXX Antibody (9O762)
Anti-DAXX Antibody (9O762)
还可以产品编号 TMAC-01118 别名 MGC126246, MGC126245, hDaxx, Fas death domain associated protein, Fas binding protein, ETS1 associated protein 1, EAP1, EAP 1, Death domain associated protein 6, Death associated protein 6, DAP6, DAP 6, CENP-C binding protein, BING2, BING 2
Anti-DAXX Antibody (9O762) 是一种 Rabbit 抗体，靶向 DAXX。Anti-DAXX Antibody (9O762) 可用于 WB,ICC,FCM。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,480 | 5日内发货 | |
| 100 μL | ¥ 2,495 | 5日内发货 |
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产品介绍
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偶联与修饰
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| 产品描述 | Anti-DAXX Antibody (9O762) is a Rabbit antibody targeting DAXX. Anti-DAXX Antibody (9O762) can be used in WB,ICC,FCM. |
| 别名 | MGC126246, MGC126245, hDaxx, Fas death domain associated protein, Fas binding protein, ETS1 associated protein 1, EAP1, EAP 1, Death domain associated protein 6, Death associated protein 6, DAP6, DAP 6, CENP-C binding protein, BING2, BING 2 |
| Ig Type | IgG |
| 克隆号 | 9O762 |
| 交叉反应 | Human |
| 验证活性 | 1. Western blot analysis of Daxx on different lysates using anti-Daxx antibody at 1/1,000 dilution. Positive control: Lane 1: Hela, Lane 2: A549, Lane 3: SW480. 2. ICC staining Daxx in Hela cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 3. ICC staining Daxx in PANC-1 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 4. Flow cytometric analysis of Hela cells with Daxx antibody at 1/50 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black). Alexa Fluor 488-conjugated goat anti rabbit IgG was used as the secondary antibody. |
| 应用 | |
| 推荐剂量 | WB: 1:1000-2000; ICC: 1:50-200; FCM: 1:50-100 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | Recombinant Antibody |
| 纯化方式 | ProA affinity purified |
| 性状 | Liquid |
| 缓冲液 | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| 研究背景 | Activation of the cell surface receptor FAS by FAS ligand leads to the initiation of apoptosis, a process necessary for the regulation of the immune system and tissue homeostasis. FAS-mediated apoptosis appears to involve a number of divergent and overlapping pathways. Daxx appears to be a central component of a FAS-mediated apoptotic pathway involving the activation of Jun N-terminal kinase (JNK). Although Daxx itself does not contain a death domain, it specifically binds to the death domain of FAS. Overexpression of Daxx activates the JNK pathway and enhances FAS-mediated apoptosis. The Daxx apoptotic pathway acts cooperatively with but is distinct from the FAS-mediated pathway that involves interactions between the death domain-containing protein FADD and the cysteine protease FLICE. Unlike the FAS-FADD-FLICE pathway, the Daxx pathway is sensitive to the apoptotic inhibitor protein Bcl-2. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Protein |
| Uniprot ID |
| 分子量 | Theoretical: 81 kDa. |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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