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Anti-DAP12 Antibody (2G400)

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产品编号 TMAC-01104

别名 TYRO protein tyrosine kinase binding protein, TYOBP, PLOSL, Killer-activating receptor-associated protein, KAR-associated protein, KARAP, DNAX-activation protein 12, DAP12, DAP 12

Anti-DAP12 Antibody (2G400) 是一种 Rabbit 抗体，靶向 DAP12。Anti-DAP12 Antibody (2G400) 可用于 FCM,IHC,WB。

Anti-DAP12 Antibody (2G400)

Anti-DAP12 Antibody (2G400)

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产品编号 TMAC-01104 别名 TYRO protein tyrosine kinase binding protein, TYOBP, PLOSL, Killer-activating receptor-associated protein, KAR-associated protein, KARAP, DNAX-activation protein 12, DAP12, DAP 12

Anti-DAP12 Antibody (2G400) 是一种 Rabbit 抗体，靶向 DAP12。Anti-DAP12 Antibody (2G400) 可用于 FCM,IHC,WB。

规格价格库存数量
50 μL
¥ 1,490
5日内发货
100 μL
¥ 2,490
5日内发货
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产品介绍

生物活性
产品描述
Anti-DAP12 Antibody (2G400) is a Rabbit antibody targeting DAP12. Anti-DAP12 Antibody (2G400) can be used in FCM,IHC,WB.
别名TYRO protein tyrosine kinase binding protein, TYOBP, PLOSL, Killer-activating receptor-associated protein, KAR-associated protein, KARAP, DNAX-activation protein 12, DAP12, DAP 12
Ig Type
IgG
克隆号
2G400
交叉反应
Human
验证活性
1. Western blot analysis of DAP12 on THP-1 cell using anti-DAP12 antibody at 1/500 dilution.
2. Immunohistochemical analysis of paraffin-embedded human lung cancer tissue using anti-DAP12 antibody. Counter stained with hematoxylin.
3. Flow cytometric analysis of K562 cells with DAP12 antibody at 1/100 dilution (purple) compared with an unlabelled control (cells without incubation with primary antibody; yellow). Alexa Fluor 488-conjugated goat anti-rabbit IgG was used as the secondary antibody.
verifiedActivityverifiedActivityverifiedActivity
应用FCMIHCWB
推荐剂量
WB: 1:500-1000; IHC: 1:50-200; FCM: 1:50-100
抗体种类
Monoclonal
宿主来源Rabbit
构建方式Recombinant Antibody
纯化方式ProA affinity purified
性状Liquid
缓冲液1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
研究背景Natural killer (NK) cells are regulated by stimulatory and inhibitory signals from a variety of receptors. Three main receptor families are responsible for NK cells recognition of MHC I molecules, including Ly-49, CD94/NKG2 and KIR (killer-cell inhibitory receptor). DAP12 is a phosphoprotein that is involved in the activation of NK cells. This protein interacts with membrane glycoproteins of the KIR family, resulting in cellular activation. DAP12 also binds to CD94/NKG2C, an activating NK cell receptor belonging to the C-type lectin superfamily. Additional proteins that bind to DAP12 include Ly-49D and Ly-49H, which associate with DAP12 in the plasma membrane. Phosphorylated DAP12 binds to ZAP-70 and Syk, suggesting that the activation pathway may be similar to that of the T and B cell antigen receptors.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
A synthesized peptide: within human DAP12 aa 60-100
抗原种属
human
Uniprot ID
O43914
化学信息
分子量Theoretical: 12 kDa.
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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