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Anti-CREB1 Antibody (9W878)
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产品编号 TMAC-00964
别名 Cyclic AMP-responsive element-binding protein 1, CREB-1, CREB1, cAMP-responsive element-binding protein 1
Anti-CREB1 Antibody (9W878) 是一种 Rabbit 抗体，靶向 CREB1。Anti-CREB1 Antibody (9W878) 可用于 WB,ICC/IF,IHC,IP,FCM。
Anti-CREB1 Antibody (9W878)
Anti-CREB1 Antibody (9W878)
还可以产品编号 TMAC-00964 别名 Cyclic AMP-responsive element-binding protein 1, CREB-1, CREB1, cAMP-responsive element-binding protein 1
Anti-CREB1 Antibody (9W878) 是一种 Rabbit 抗体，靶向 CREB1。Anti-CREB1 Antibody (9W878) 可用于 WB,ICC/IF,IHC,IP,FCM。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,485 | 5日内发货 | |
| 100 μL | ¥ 2,485 | 5日内发货 |
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| 产品描述 | Anti-CREB1 Antibody (9W878) is a Rabbit antibody targeting CREB1. Anti-CREB1 Antibody (9W878) can be used in WB,ICC/IF,IHC,IP,FCM. |
| 别名 | Cyclic AMP-responsive element-binding protein 1, CREB-1, CREB1, cAMP-responsive element-binding protein 1 |
| Ig Type | IgG |
| 交叉反应 | Human,Mouse,Rat,zebrafish |
| 验证活性 | 1. Western blot analysis of CREB on different cell lysates using anti-CREB antibody at 1/1,000 dilution. Positive control: Lane 1: Hela, Lane 2: HepG2, Lane 3: Jurkat, Lane 4: NIH/3T3. 2. Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-CREB antibody. Counter stained with hematoxylin. 3. Immunohistochemical analysis of paraffin-embedded human lung cancer tissue using anti-CREB antibody. Counter stained with hematoxylin. 4. Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using anti-CREB antibody. Counter stained with hematoxylin. 5. Immunohistochemical analysis of paraffin-embedded mouse brain tissue using anti-CREB antibody. Counter stained with hematoxylin. 6. ICC staining CREB in Hela cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 7. Flow cytometric analysis of Hela cells with CREB antibody at 1/50 dilution (blue) compared with an unlabelled control (cells without incubation with primary antibody; red). Alexa Fluor 488-conjugated goat anti rabbit IgG was used as the secondary antibody. |
| 应用 | |
| 推荐剂量 | WB: 1:1000-5000; IHC: 1:50-200; ICC/IF: 1:50-200; FCM: 1:10-100 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | Recombinant Antibody |
| 纯化方式 | ProA affinity purified |
| 性状 | Liquid |
| 缓冲液 | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| 研究背景 | Eukaryotic gene transcription is regulated by sequence-specific transcription factors that bind modular cis-acting promoter and enhancer elements. The ATF/CREB transcription factor family binds the palindromic cAMP response element (CRE) octanucleotide TGACGTCA. The ATF/CREB family includes CREB-1, CREB-2 (also designated ATF-4), ATF-1, ATF-2 and ATF-3. This family of proteins contains highly divergent N-terminal domains, but shares a C-terminal leucine zipper for dimerization and DNA binding. Although CREB can bind to DNA in an unphosphorylated state, it cannot activate transcription. Phosphorylation of CREB on Ser 133 by protein kinase A facilitates its interaction with the CREB-binding protein (CBP) and activates the basal transcription complex. CREB functions in neoglucogenesis through interactions with the nuclear coactivator PGC-1. CREB may play a role in the pathogenesis of type II diabetes and dilated cardiomyopathy. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Protein |
| Uniprot ID |
| 分子量 | Theoretical: 40 kDa. |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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