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Anti-CRABP2 Antibody-FITC (6M932)
还可以产品编号 TMAY-01744F
Anti-CRABP2 Antibody-FITC (6M932) 是一种 FITC-conjugated Mouse 抗体，靶向 CRABP2。Anti-CRABP2 Antibody-FITC (6M932) 可用于 FCM。
Anti-CRABP2 Antibody-FITC (6M932)
Anti-CRABP2 Antibody-FITC (6M932)
还可以产品编号 TMAY-01744F
Anti-CRABP2 Antibody-FITC (6M932) 是一种 FITC-conjugated Mouse 抗体，靶向 CRABP2。Anti-CRABP2 Antibody-FITC (6M932) 可用于 FCM。
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抗原信息
| 产品描述 | Anti-CRABP2 Antibody-FITC (6M932) is a FITC-conjugated Mouse antibody targeting CRABP2. Anti-CRABP2 Antibody-FITC (6M932) can be used in FCM. |
| Ig Type | Monoclonal Mouse IgG1 |
| 克隆号 | 6M932 |
| 交叉反应 | Human |
| 验证活性 | Profile of anti-CRABP2 reactivity on HepG2 cells analyzed by flow cytometry. |
| 应用 | FCM |
| 推荐剂量 | 10 μl/Test, 0.1 mg/ml |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CRABP2 (rh CRABP2; TMPY-01549; NP_001869.1; Pro2-Glu138) and conjugated with FITC under optimum conditions, the unreacted FITC was removed. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | PBS solution containing 0.5% BSA and 0.09% sodium azide |
| 研究背景 | Cellular retinoic acid-binding protein 2, also known as Cellular retinoic acid-binding protein II, CRABP-II and CRABP2, is a protein which belongs to thecalycin superfamily and Fatty-acid binding protein (FABP) family. Cellular retinoic acid binding proteins (CRABP) are low molecular weight proteins whose precise function remains unknown. The predicted amino acid sequences of human CRABP1 and CRABP2 demonstrated a 99.3% and 93.5% identity to mouse CRABP1 and CRABP2, respectively. CRABP2 forms a beta-barrel structure that accommodates hydrophobic ligands in its interior. Expression of CRABP2, but not CRABP1 mRNA, was markedly increased (greater than 15-fold) by retinoic acid treatment of fibroblasts cultured from human skin, whereas no significant induction of CRABP2 mRNA was observed in human lung fibroblasts. CRABP2 transports retinoic acid to the nucleus. It regulates the access of retinoic acid to the nuclear retinoic acid receptors. CRABP2 is necessary for elastin induction by All-trans retinoic acid (ATRA) in MRC-5 cells. It is expressed at low levels in emphysema fibroblasts. This alteration in the retinoic acid signalling pathway in lung fibroblasts may contribute to the defect of alveolar repair in human pulmonary emphysema. |
| 偶联 | FITC |
| 其他可选修饰符 | Unconjugated/PE |
| 可提供抗体种类 | 3 |
| 免疫原 | Recombinant Human CRABP2 protein (TMPY-01549) |
| 抗原种属 | Human |
存储&运输
| 储存方式 | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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