Name: Anti-CD36 Antibody
Brand: TargetMol
SKU: T9901A-1456
Rating: 4.5 (1 reviews)

生物活性

产品描述	Anti-CD36 Antibody is a humanized monoclonal antibody targeting CD36 (Fatty Acid Translocase/FAT). CD36 is a multi-ligand scavenger receptor widely expressed on monocytes/macrophages, platelets, endothelial cells, and adipocytes, facilitating the uptake of long-chain fatty acids (LCFA) and the binding of oxidized low-density lipoproteins (oxLDL). By specifically binding to CD36, this antibody blocks fatty acid transport or inhibits oxLDL-induced foam cell formation, making it a valuable tool for research in metabolic disorders (e.g., atherosclerosis, diabetes) and cancer lipid metabolism.
体外活性	Anti-CD36 Antibody 有效阻断表达 CD36 的肿瘤细胞对脂肪酸（如棕榈酸）和氧化低密度脂蛋白的摄取。在共培养实验中，它通过破坏脂质摄取抑制调节性 T 细胞 (Tregs) 的代谢适应，并增强 CD8+ T 细胞的效应功能 [1][2]。
体内活性	在人及口腔癌和黑色素瘤的原位小鼠模型中，系统给予中和性Anti-CD36 Antibody几乎完全抑制了转移的起始，而对原发肿瘤生长的影响较小。该处理靶向转移起始细胞并调节肿瘤的脂质代谢环境 [1]。
别名	抗CD36抗体, Ona36
反应种属	Human
应用	ELISA FACS Functional assay
抗体种类	Monoclonal
内毒素	<1.0 EU/mg

抗体信息

同型

IgG1

偶联与修饰

偶联	Unconjugated

抗原信息

Uniprot ID	P16671
靶点	CD36

储存&溶解度

存储	store at low temperature \| -20°C for 2 years, 4°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.

Anti-CD36 Antibody