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Anti-CD23 Antibody (8N427)
还可以产品编号 TMAY-00533
Anti-CD23 Antibody (8N427) 是一种 Mouse 抗体，靶向 CD23。Anti-CD23 Antibody (8N427) 可用于 FCM。
Anti-CD23 Antibody (8N427)
Anti-CD23 Antibody (8N427)
还可以产品编号 TMAY-00533
Anti-CD23 Antibody (8N427) 是一种 Mouse 抗体，靶向 CD23。Anti-CD23 Antibody (8N427) 可用于 FCM。
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-CD23 Antibody (8N427) is a Mouse antibody targeting CD23. Anti-CD23 Antibody (8N427) can be used in FCM. |
| Ig Type | Monoclonal Mouse IgG1 |
| 克隆号 | 8N427 |
| 交叉反应 | Human |
| 验证活性 | Flow cytometric analysis of Human CD23 expression on human whole blood lymphocytes. Cells were stained with purified anti-Human CD23, then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells. |
| 应用 | FCM |
| 推荐剂量 | FCM: 1:25-1:100 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CD23/FCER2 (rh CD23/FCER2; TMPY-02293; P06734-1; Asp48-Ser321). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | Fc fragment of IgE, low affinity II, receptor for (CD23) or CD23 antigen is a member of the cluster of differentiation family. The cluster of differentiation (cluster of designation) (often abbreviated as CD) is a protocol used for the identification and investigation of cell surface molecules present on white blood cells initially but found in almost any kind of cell of the body, providing targets for immunophenotyping of cells. Physiologically, CD molecules can act in numerous ways, often acting as receptors or ligands (the molecule that activates a receptor) important to the cell. A signal cascade is usually initiated, altering the behavior of the cell (see cell signaling). Some CD proteins do not play a role in cell signaling, but have other functions, such as cell adhesion. CD23/FCER2 is a B-cell specific antigen, and a low-affinity receptor for IgE. It has essential roles in B cell growth and differentiation, and the regulation of IgE production. This protein also exists as a soluble secreted form, then functioning as a potent mitogenic growth factor. Increased levels of soluble CD23/FCER2 cause the recruitment of non-sensitised B-cells in the presentation of antigen peptides to allergen-specific B-cells, therefore increasing the production of allergen specific IgE. IgE, in turn, is known to upregulate the cellular expression of CD23 and Fc epsilon RI (high-affinity IgE receptor). |
| 偶联 | Unconjugated |
| 其他可选修饰符 | APC/PerCP/FITC/PE |
| 可提供抗体种类 | 5 |
| 免疫原 | Recombinant Human CD23/FCER2 Protein (TMPY-02293) |
| 抗原种属 | Human |
| 研究领域 | Fc Receptors, ITIM/ITAM Immunoreceptors and Related Molecules |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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