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Anti-CAV1 Antibody (2M160)
还可以产品编号 TMAH-00146
别名 Caveolin-1, CAV 1, CAV
Anti-CAV1 Antibody (2M160) 是一种抗体，靶向 CAV1。Anti-CAV1 Antibody (2M160) 可用于 ELISA, WB, FC。
Anti-CAV1 Antibody (2M160)
Anti-CAV1 Antibody (2M160)
还可以产品编号 TMAH-00146 别名 Caveolin-1, CAV 1, CAV
Anti-CAV1 Antibody (2M160) 是一种抗体，靶向 CAV1。Anti-CAV1 Antibody (2M160) 可用于 ELISA, WB, FC。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,300 | 5日内发货 | |
| 100 μL | ¥ 2,185 | 5日内发货 |
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-CAV1 Antibody (2M160) is an antibody targeting CAV1. Anti-CAV1 Antibody (2M160) can be used in ELISA, WB, FC. |
| 别名 | Caveolin-1, CAV 1, CAV |
| Ig Type | Rabbit IgG |
| 克隆号 | 2M160 |
| 交叉反应 | Human |
| 验证活性 | 1. Western Blot -Positive WB detected in: THP-1 whole cell lysate -All lanes: Caveolin-1 antibody at 1:1000 -Secondary: Goat polyclonal to rabbit IgG at 1/50000 dilution -Predicted band size: 20 kDa -Observed band size: 20 kDa 2. Overlay Peak curve showing Hela cells stained with TMAH-00146 (red line) at 1:50. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1µg/1*10^6 cells) for 45min at 4°C. The secondary antibody used was FITC-conjugated Goat Anti-rabbit IgG(H+L) at 1:200 dilution for 35min at 4°C.Control antibody (green line) was rabbit IgG (1µg/1*10^6 cells) used under the same conditions. Acquisition of >10,000 events was performed. |
| 应用 | ELISA, WB, FC |
| 推荐剂量 | WB:1:500-1:2000; FC:1:50-1:200. |
| 抗体种类 | Monoclonal |
| 亚细胞定位 | Golgi apparatus membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Membrane, caveola; Peripheral membrane protein. Membrane raft. Golgi apparatus, trans-Golgi network. Note=Colocalized with DPP4 in membrane rafts. Potential hairpin-like structure in the membrane. Membrane protein of caveolae. |
| 构建方式 | Recombinant Antibody |
| 纯化方式 | Affinity-chromatography |
| 性状 | Liquid |
| 缓冲液 | Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| 研究背景 | May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway. Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation. |
| 偶联 | Unconjugated |
| 免疫原 | A synthetic peptide: Human CAV1 |
| 抗原种属 | Human |
| 基因ID | 857 |
| Uniprot ID | |
| 研究领域 | Cancer, Cardiovascular, Tags & Cell Markers, Metabolism, Signal transduction |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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