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Anti-Cathepsin D Polyclonal Antibody 2

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货号 TMAB-03683

Anti-Cathepsin D Polyclonal Antibody 2 是一种 Rabbit 抗体，靶向 Cathepsin D。Anti-Cathepsin D Polyclonal Antibody 2 可用于 WB,IHC-P,IHC-Fr,IF。

Anti-Cathepsin D Polyclonal Antibody 2

Anti-Cathepsin D Polyclonal Antibody 2

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Rating icon 还可以
货号 TMAB-03683

Anti-Cathepsin D Polyclonal Antibody 2 是一种 Rabbit 抗体，靶向 Cathepsin D。Anti-Cathepsin D Polyclonal Antibody 2 可用于 WB,IHC-P,IHC-Fr,IF。

规格价格库存数量
50 μL
¥ 1,170
5日内发货
100 μL
¥ 1,970
5日内发货
200 μL
¥ 2,780
5日内发货
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产品介绍

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产品描述
Anti-Cathepsin D Polyclonal Antibody 2 is a Rabbit antibody targeting Cathepsin D. Anti-Cathepsin D Polyclonal Antibody 2 can be used in WB,IHC-P,IHC-Fr,IF.
Ig Type
IgG
反应种属
Mouse (predicted:Rat)
应用WBIHC-PIHC-FrIF
推荐剂量
WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Lysosome. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
组织特异性Expressed in the aorta extrcellular space (at protein level).
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景Cathepsin D is a normal lysosomal protease that is expressed in all cells. It is an aspartyl protease with a pH optimum in the range of 3-5, and contains two N-linked oligosaccharides. Cathepsin D is synthesized as an inactive 52 kDa pro enzyme. Activation involves the proteolytic removal of the 43 amino acid profragment and an internal cleavage to generate the two-chain form made up of 34 and 14 kDa subunits. Cathepsin D contains the mannose-6-phosphate lysosomal localization signal that targets the enzyme to the lysosomal compartment where it functions in the normal degradation of proteins. In certain tumor cells, Cathepsin D is abnormally processed and is secreted in its 52 kDa precursor form. Numerous clinical studies as well as in vitro evidence suggest that cathepsin D plays an important role in malignant transformation and may be a useful prognostic indicator for breast cancer and possibly Alzheimer's disease.
抗原信息
免疫原
KLH conjugated synthetic peptide: mouse Cathepsin D heavy chain
抗原种属
Mouse
基因名称
CTSD
基因ID
13033
蛋白名称
Cathepsin D
Uniprot ID
P18242
功能
Acid protease active in intracellular protein breakdown. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease.
化学信息
分子量Theoretical: 45 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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