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顶部生物活性储存和溶解信息计算器

Anti-Caspase-3 Antibody (1F439)

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Anti-Caspase-3 Antibody (1F439)
产品编号 TMAC-03427
别名 Yama, SCA-1, CPP32B, CPP32, apopain

Anti-Caspase-3 Antibody (1F439) 是一种 Rabbit 抗体，靶向 Caspase-3。Anti-Caspase-3 Antibody (1F439) 可用于 WB,ICC/IF,IHC,IP,FCM。

Anti-Caspase-3 Antibody (1F439)

Anti-Caspase-3 Antibody (1F439)

Rating icon 还可以
Anti-Caspase-3 Antibody (1F439)
产品编号 TMAC-03427 别名 Yama, SCA-1, CPP32B, CPP32, apopain

Anti-Caspase-3 Antibody (1F439) 是一种 Rabbit 抗体，靶向 Caspase-3。Anti-Caspase-3 Antibody (1F439) 可用于 WB,ICC/IF,IHC,IP,FCM。

规格价格库存数量
50 μL
¥ 1,490
5日内发货
100 μL
¥ 2,495
5日内发货
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产品介绍

生物活性
产品描述
Anti-Caspase-3 Antibody (1F439) is a Rabbit antibody targeting Caspase-3. Anti-Caspase-3 Antibody (1F439) can be used in WB,ICC/IF,IHC,IP,FCM.
别名Yama, SCA-1, CPP32B, CPP32, apopain
Ig Type
IgG
交叉反应
Human,Mouse
验证活性
1. Western blot analysis of pro Caspase 3 expression in Jurkat cell lysate.
2. All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.
3. Immunohistochemical analysis of paraffin-embedded human colon, using pro Caspase 3 Antibody.
4. Immunofluorescent analysis of Hela cells, using pro Caspase 3 Antibody.
应用
WB
ICC/IF
IHC
IP
FCM
推荐剂量
WB: 1:1000-2000; IHC: 1:100-200; ICC/IF: 1:50-200; IP: 1:20-50; FCM: 1:20-100
抗体种类
Monoclonal
宿主来源Rabbit
构建方式Recombinant Antibody
纯化方式Affinity-chromatography
性状Liquid
缓冲液Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
研究背景Caspase-3, also known as apopain, SCA-1, Yama and CPP32, is an aspartate-specific cysteine protease that belongs to the ICE subfamily of caspases. Caspase-3 is expressed in cells as an inactive precursor from which the p17 and p11 subunits of the mature caspase-3 are proteolytically generated during apoptosis. The caspase-3 precursor is first cleaved at Asp175-Ser176 to produce the p11 subunit and the p20 peptide. Subsequently, the p20 peptide is cleaved at Asp28-Ser29 to generate the mature p17 subunit. The active caspase-3 enzyme is a heterodimer composed of two p17 and two p11 subunits. At the onset of apoptosis, caspase-3 proteolytically cleaves PARP at an Asp216-Gly217 bond. During the execution of the apoptotic cascade, activated caspase-3 releases SREBP from the membrane of the ER in a proteolytic reaction that is distinct from their normal sterol-dependent activation. Caspase-3 cleaves and activates SREBPs between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Caspase-3 also cleaves and activates caspase-6, -7 and -9. The human caspase-3 gene encodes a cytoplasmic protein that is highly expressed in lung, spleen, heart, liver, kidney and cells of the immune system.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
A synthesized peptide: human Caspase 3
抗原种属
human
Uniprot ID
P42574
化学信息
分子量Theoretical: 35 kDa.
存储&运输
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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