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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-Cadherin-1 Polyclonal Antibody

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货号 TMAB-03549

Anti-Cadherin-1 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Cadherin-1。Anti-Cadherin-1 Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。

Anti-Cadherin-1 Polyclonal Antibody

Anti-Cadherin-1 Polyclonal Antibody

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Rating icon 还可以
货号 TMAB-03549

Anti-Cadherin-1 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Cadherin-1。Anti-Cadherin-1 Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。

规格价格库存数量
50 μL
¥ 1,175
5日内发货
100 μL
¥ 1,960
5日内发货
200 μL
¥ 2,790
5日内发货
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产品介绍

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产品描述
Anti-Cadherin-1 Polyclonal Antibody is a Rabbit antibody targeting Cadherin-1. Anti-Cadherin-1 Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Ig Type
IgG
反应种属
Human,Mouse (predicted:Rat)
应用IHC-PIHC-FrIF
推荐剂量
IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Cell junction. Cell membrane; Single-pass type I membrane protein.
组织特异性Non-neural epithelial tissues.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function of this gene is thought to contribute to cancer progression by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. This gene is present in a gene cluster with other members of the cadherin family on chromosome 16. [provided by RefSeq, Nov 2015]
抗原信息
免疫原
Recombinant Protein: human E cadherin protein
抗原种属
Human
基因名称
CDH1
基因ID
999
蛋白名称
Cadherin-1
Uniprot ID
P12830
功能
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7.
E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production.
化学信息
分子量Theoretical: 97 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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