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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-BRCA2 Polyclonal Antibody 3

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货号 TMAB-03208

Anti-BRCA2 Polyclonal Antibody 3 是一种 Rabbit 抗体，靶向 BRCA2。Anti-BRCA2 Polyclonal Antibody 3 可用于 ICC/IF。

Anti-BRCA2 Polyclonal Antibody 3

Anti-BRCA2 Polyclonal Antibody 3

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Rating icon 还可以
货号 TMAB-03208

Anti-BRCA2 Polyclonal Antibody 3 是一种 Rabbit 抗体，靶向 BRCA2。Anti-BRCA2 Polyclonal Antibody 3 可用于 ICC/IF。

规格价格库存数量
50 μL
¥ 1,160
5日内发货
100 μL
¥ 1,960
5日内发货
200 μL
¥ 2,780
5日内发货
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产品介绍

生物活性
产品描述
Anti-BRCA2 Polyclonal Antibody 3 is a Rabbit antibody targeting BRCA2. Anti-BRCA2 Polyclonal Antibody 3 can be used in ICC/IF.
Ig Type
IgG
反应种属
Human
应用ICC/IF
推荐剂量
ICC/IF: 1:50-200
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Nuclear protein.
组织特异性Highest levels of expression in breast and thymus, with slightly lower levels in lung, ovary and spleen.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintenance of genome stability, specifically the homologous recombination pathway for double-strand DNA repair. The largest exon in both genes is exon 11, which harbors the most important and frequent mutations in breast cancer patients. The BRCA2 gene was found on chromosome 13q12.3 in human. The BRCA2 protein contains several copies of a 70 aa motif called the BRC motif, and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair. BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations generally exhibit loss of heterozygosity (LOH) of the wild-type allele. [provided by RefSeq, May 2020]
抗原信息
免疫原
KLH conjugated synthetic peptide: human BRCA2
抗原种属
Human
基因名称
BRCA2
基因ID
675
蛋白名称
Breast cancer type 2 susceptibility protein
Uniprot ID
P51587
功能
Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51-ssDNA filaments by blocking ATP hydrolysis. May participate in S phase checkpoint activation. Binds selectively to ssDNA, and to ssDNA in tailed duplexes and replication fork structures. In concert with NPM1, regulates centrosome duplication.
化学信息
分子量Theoretical: 384 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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