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Anti-BID Antibody-HRP (1O729)
还可以产品编号 TMAY-00868H
Anti-BID Antibody-HRP (1O729) 是一种 HRP-conjugated Mouse 抗体，靶向 BID。Anti-BID Antibody-HRP (1O729) 可用于 ELISA。
Anti-BID Antibody-HRP (1O729)
Anti-BID Antibody-HRP (1O729)
还可以产品编号 TMAY-00868H
Anti-BID Antibody-HRP (1O729) 是一种 HRP-conjugated Mouse 抗体，靶向 BID。Anti-BID Antibody-HRP (1O729) 可用于 ELISA。
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-BID Antibody-HRP (1O729) is a HRP-conjugated Mouse antibody targeting BID. Anti-BID Antibody-HRP (1O729) can be used in ELISA. |
| Ig Type | Monoclonal Mouse IgG2a |
| 克隆号 | 1O729 |
| 交叉反应 | Human |
| 应用 | ELISA |
| 推荐剂量 | ELISA: 0.1-1 μg/ml |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human BID (rh BID; TMPY-02027; P55957-1; Met 1-Asp 195). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography and conjugated with horseradish-peroxidase (HRP). |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | The BH3 interacting domain death agonist (BID) is a pro-apoptotic member of the Bcl-2 protein family, which contains only the BH3 domain, and is required for its interaction with the Bcl-2 family proteins and for its pro-death activity. BID is important to cell death mediated by these proteases and thus is the sentinel to protease-mediated death signals. Recent studies further indicate that Bid may be more than just a killer molecule, it could be also involved in the maintenance of genomic stability by engaging at mitosis checkpoint. BID is an integrating key regulator of the intrinsic death pathway that amplifies caspase-dependent and caspase-independent execution of neuronal apoptosis. Therefore pharmacological inhibition of BID provides a promising therapeutic strategy in neurological diseases where programmed cell death is prominent. BID is activated by Caspase 8 in response to Fas/TNF-R1 death receptor activation. Activated BID is translocated to mitochondria and induces cytochrome c release, which in turn activates downstream caspases. BID action has been proposed to involve the mitochondrial re-location of its truncated form, tBid, to facilitate the release of apoptogenic proteins like cytochrome c. |
| 偶联 | HRP |
| 其他可选修饰符 | Unconjugated |
| 可提供抗体种类 | 2 |
| 免疫原 | Recombinant Human BID protein (TMPY-02027) |
| 抗原种属 | Human |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. Keep away from direct sunlight. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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