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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-BHLHB9/p60TRP Polyclonal Antibody

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货号 TMAB-03135

Anti-BHLHB9/p60TRP Polyclonal Antibody 是一种 Rabbit 抗体，靶向 BHLHB9/p60TRP。Anti-BHLHB9/p60TRP Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。

Anti-BHLHB9/p60TRP Polyclonal Antibody

Anti-BHLHB9/p60TRP Polyclonal Antibody

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Rating icon 还可以
货号 TMAB-03135

Anti-BHLHB9/p60TRP Polyclonal Antibody 是一种 Rabbit 抗体，靶向 BHLHB9/p60TRP。Anti-BHLHB9/p60TRP Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。

规格价格库存数量
50 μL
¥ 1,160
5日内发货
100 μL
¥ 1,970
5日内发货
200 μL
¥ 2,790
5日内发货
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产品介绍

生物活性
产品描述
Anti-BHLHB9/p60TRP Polyclonal Antibody is a Rabbit antibody targeting BHLHB9/p60TRP. Anti-BHLHB9/p60TRP Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Ig Type
IgG
反应种属
Mouse (predicted:Human,Rat,Dog,Pig,Cow,Horse,Sheep)
应用IHC-PIHC-FrIF
推荐剂量
IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Cytoplasm. Nucleus. Note=Mainly cytoplasmic, and nuclear at lower level.
组织特异性Highly expressed in brain. Not expressed in lung or liver. Down-regulated in brain from patients suffering from Alzheimer disease.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景Basic helix-loop-helix (bHLH) proteins are a group of transcription factors that influence the regulation of neurogenesis, cardiogenesis, myogenesis, differentiation and cell proliferation. p60TRP (p60-transcription-regulator-protein), also known as BHLHb9 (basic helix-loop-helix domain containing, class B, 9) or p60-like protein, is a 547 amino acid cytoplasmic and nuclear protein that belongs to the GPRASP family. A few members of the GRASP family are considered G protein-coupled receptors that play a role in many different stimulus-response pathways. Highly expressed in brain, p60TRP may be involved in the control of cellular aging and survival. In colon cancer cells, p60TRP is down regulated due to CpG hypermethylation of its promoter, and patients suffering from Alzheimer disease have low levels of p60TRP. p60TRP binds to karyopherin ∫3, also known as Ran BP-5, and protein-phosphatase-2A (PP2A), and is encoded by a gene located on human chromosome Xq22.1.
抗原信息
免疫原
KLH conjugated synthetic peptide: human BHLHB9/p60TRP
抗原种属
Human
基因名称
BHLHB9
基因ID
80823
蛋白名称
Protein BHLHb9
功能
BHLHB9, or basic helix loop helix domain containing, class B 9, interacts with the Ran-binding-protein-5 (RanBP5) and the protein-phosphatase-2A (PP2A). It can also affect NNT1 and p48ZnF signaling and is down-regulated in the brain of AD subjects. Thus BHLHB9 may have a possible pivotal role in the control of cellular aging and survival. Hypermethylation of the BHLHB9 gene occurs in premalignant lesions and accumulates during tumorigenesis.
化学信息
分子量Theoretical: 60 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

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