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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-Bag1 Antibody (7J25)

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货号 TMAB-03014

Anti-Bag1 Antibody (7J25) 是一种 Rabbit 抗体，靶向 Bag1。Anti-Bag1 Antibody (7J25) 可用于 WB,IHC-P,IHC-Fr,ICC/IF,IF,FCM。

Anti-Bag1 Antibody (7J25)

Anti-Bag1 Antibody (7J25)

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Rating icon 还可以
货号 TMAB-03014

Anti-Bag1 Antibody (7J25) 是一种 Rabbit 抗体，靶向 Bag1。Anti-Bag1 Antibody (7J25) 可用于 WB,IHC-P,IHC-Fr,ICC/IF,IF,FCM。

规格价格库存数量
25 μL
¥ 780
5日内发货
50 μL
¥ 1,390
5日内发货
100 μL
¥ 2,490
5日内发货
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产品介绍

生物活性
产品描述
Anti-Bag1 Antibody (7J25) is a Rabbit antibody targeting Bag1. Anti-Bag1 Antibody (7J25) can be used in WB,IHC-P,IHC-Fr,ICC/IF,IF,FCM.
Ig Type
IgG
克隆号
7J25
反应种属
Human (predicted:Mouse,Rat)
应用WBIHC-PIHC-FrICC/IFIFFCM
推荐剂量
WB: 1:500-1000; IHC-P: 1:50-200; IHC-Fr: 1:50-200; ICC/IF: 1:50-200; IF: 1:50-200; FCM: 1:50-100
抗体种类
Monoclonal
宿主来源Rabbit
亚细胞定位Cytoplasm. Nucleus. Isoform 2 localizes to the cytoplasm and shuttles into the nucleus in response to heat shock; Nucleus. Cytoplasm. Isoform 1 localizes predominantly to the nucleus and Cytoplasm. Nucleus. Isoform 4 localizes predominantly to the cytoplasm. The cellular background in which it is expressed can influence whether it resides primarily in the cytoplasm or is also found in the nucleus. In the presence of BCL2, localizes to intracellular membranes (what appears to be the nuclear envelope and perinuclear membranes) as well as punctate cytosolic structures suggestive of mitochondria.
组织特异性Isoform 4 is the most abundantly expressed isoform. It is ubiquitously expressed throughout most tissues, except the liver, colon, breast and uterine myometrium. Isoform 1 is expressed in the ovary and testis. Isoform 4 is expressed in several types of tumor cell lines, and at consistently high levels in leukemia and lymphoma cell lines. Isoform 1 is expressed in the prostate, breast and leukemia cell lines. Isoform 3 is the least abundant isoform in tumor cell lines.
构建方式Recombinant Antibody
纯化方式Protein A purified
性状Liquid
缓冲液10mM phosphate buffered saline (pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
研究背景Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleotide release is mediated via its binding to the nucleotide-binding domain (NBD) of HSPA8/HSC70 where as the substrate release is mediated via its binding to the substrate-binding domain (SBD) of HSPA8/HSC70.
抗原信息
免疫原
A synthesized peptide: human BAG1
抗原种属
Human
基因名称
BAG1
基因ID
573
蛋白名称
BAG family molecular chaperone regulator 1
Uniprot ID
Q99933
功能
Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Inhibits the pro-apoptotic function of PPP1R15A, and has anti-apoptotic activity. Markedly increases the anti-cell death function of BCL2 induced by various stimuli.
化学信息
分子量Theoretical: 39 kDa. Actual: 33, 46, 50 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

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