Anti-AXL Antibody (1F430)

Name: Anti-AXL Antibody (1F430)
Brand: TargetMol
SKU: TMAY-00553
Rating: 4.5 (1 reviews)

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产品编号 TMAY-00553

Anti-AXL Antibody (1F430) 是一种 Mouse 抗体，靶向 AXL。Anti-AXL Antibody (1F430) 可用于 ELISA,FCM。

Anti-AXL Antibody (1F430)

还可以

产品编号 TMAY-00553

Anti-AXL Antibody (1F430) 是一种 Mouse 抗体，靶向 AXL。Anti-AXL Antibody (1F430) 可用于 ELISA,FCM。

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生物活性

产品描述	Anti-AXL Antibody (1F430) is a Mouse antibody targeting AXL. Anti-AXL Antibody (1F430) can be used in ELISA,FCM.
Ig Type	Monoclonal Mouse IgG1
克隆号	1F430
交叉反应	Human
验证活性	Flow cytometric analysis of Human AXL expression on DU145 cells. Cells were stained with purified anti-Human AXL, then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells.
应用	ELISA,FCM
推荐剂量	ELISA: 1:1000-1:2000; FCM: 1:25-1:100
抗体种类	Monoclonal
宿主来源	Mouse
构建方式	This product is a recombinant monoclonal antibody expressed from HEK293 cells.
纯化方式	Protein A
性状	Liquid
缓冲液	0.2 μm filtered solution in PBS
研究背景	Axl receptor tyrosine kinase, together with Tyro3 and Mer, constitute the TAM family of receptor tyrosine kinases. In the nervous system, Axl and its ligand Growth-arrest-specific protein 6 (Gas6) are expressed on multiple cell types. Axl functions in dampening the immune response, regulating cytokine secretion, clearing apoptotic cells and debris, and maintaining cell survival. Axl is upregulated in various disease states, such as in the cuprizone toxicity-induced model of demyelination and in multiple sclerosis (MS) lesions, suggesting that it plays a role in disease pathogenesis. Axl expression correlates with poor prognosis in several cancers. Axl mediates multiple oncogenic phenotypes and activation of these RTKs constitutes a mechanism of chemoresistance in a variety of solid tumors. Axl contributes to cell survival, migration, invasion, metastasis and chemosensitivity justify further investigation of Axl as novel therapeutic targets in cancer. The receptor tyrosine kinase AXL is thought to play a role in metastasis. The soluble AXL receptor as a therapeutic candidate agent for treatment of metastatic ovarian cancer. GAS6/AXL targeting as an effective strategy for inhibition of metastatic tumor progression in vivo.

偶联与修饰

偶联	Unconjugated
其他可选修饰符	FITC/PE
可提供抗体种类	3

抗原信息

免疫原	Recombinant Human AXL Protein (TMPY-01601)
抗原种属	Human
研究领域	Receptor Tyrosine Kinases (RTKs)

存储&运输

储存方式	Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
运输方式	Shipping with blue ice.