Anti-ATR Antibody (4D945)

Name: Anti-ATR Antibody (4D945)
Brand: TargetMol
SKU: TMAB-02960
Rating: 4.5 (1 reviews)

一键复制产品信息

还可以

货号 TMAB-02960

Anti-ATR Antibody (4D945) 是一种 Mouse 抗体，靶向 ATR。Anti-ATR Antibody (4D945) 可用于 WB。

Anti-ATR Antibody (4D945)

一键复制产品信息

还可以

货号 TMAB-02960

Anti-ATR Antibody (4D945) 是一种 Mouse 抗体，靶向 ATR。Anti-ATR Antibody (4D945) 可用于 WB。

规格	价格	库存	数量
50 μL	¥ 1,565	5日内发货
100 μL	¥ 2,495	5日内发货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

大包装 & 定制

加入购物车

TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

资源下载:

产品操作手册

生物活性

产品描述	Anti-ATR Antibody (4D945) is a Mouse antibody targeting ATR. Anti-ATR Antibody (4D945) can be used in WB.
Ig Type	IgG1, Kappa
克隆号	4D945
反应种属	Human
应用	WB
推荐剂量	WB: 1:500-2000
抗体种类	Monoclonal
宿主来源	Mouse
亚细胞定位	Cytoplasm. Nucleus. Note=Mainly cytoplasmic and weakly nuclear. Upon TNF activation and subsequent phosphorylation, it translocates from the cytoplasm to the nucleus.
组织特异性	Ubiquitous, with highest expression in testis. Isoform 2 is found in pancreas, placenta and liver but not in heart, testis and ovary.
构建方式	Recombinant Antibody
纯化方式	Protein G purified
性状	Liquid
缓冲液	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度	1mg/ml
研究背景	Ataxia Telangiectasia Mutated (ATM) and Rad 3-related protein (ATR) is a phosphatidylinositol kinase (PK)-related kinase which functions in response to DNA damage and repair as well as at DNA replication checkpoints during the cell cycle. ATR is a member of the DNA-PK kinases closely related to ATM and DNA-PK for which DNA stimulates the observed kinase activity. Chromosomal remodeling proteins have also been reported to associate with ATR complexes. Several known components of the NuRD complex including histone deacetylase 1 (HDAC1), HDAC2, and CHD4

抗原信息

基因名称	ATR
基因ID	545
蛋白名称	Serine/threonine-protein kinase ATR
功能	Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates BRCA1, CHEK1, MCM2, RAD17, RPA2, SMC1 and p53/TP53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at sites of DNA damage, thereby regulating DNA damage response mechanism. Required for FANCD2 ubiquitination. Critical for maintenance of fragile site stability and efficient regulation of centrosome duplication.

储存&溶解度

储存方式	Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式	Shipping with blue ice.
存储	store at low temperature \| -20°C for 1 year

Related Tags: buy Anti-ATR Antibody (4D945) | purchase Anti-ATR Antibody (4D945) | Anti-ATR Antibody (4D945) cost | order Anti-ATR Antibody (4D945)