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Anti-AR/Androgen receptor Antibody (3C609) (ready to use)

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货号 TMAB-02799

Anti-AR/Androgen receptor Antibody (3C609) 是一种 Mouse 抗体，靶向 AR/Androgen receptor。Anti-AR/Androgen receptor Antibody (3C609) 可用于 IHC-P,IHC-Fr,ICC/IF,IF。

Anti-AR/Androgen receptor Antibody (3C609) (ready to use)

Anti-AR/Androgen receptor Antibody (3C609) (ready to use)

一键复制产品信息
Rating icon 还可以
货号 TMAB-02799

Anti-AR/Androgen receptor Antibody (3C609) 是一种 Mouse 抗体，靶向 AR/Androgen receptor。Anti-AR/Androgen receptor Antibody (3C609) 可用于 IHC-P,IHC-Fr,ICC/IF,IF。

规格价格库存数量
3 mL
¥ 540
5日内发货
6 mL
¥ 975
5日内发货
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产品介绍

生物活性
产品描述
Anti-AR/Androgen receptor Antibody (3C609) is a Mouse antibody targeting AR/Androgen receptor. Anti-AR/Androgen receptor Antibody (3C609) can be used in IHC-P,IHC-Fr,ICC/IF,IF.
Ig Type
IgG2b
克隆号
3C609
反应种属
Human
应用IHC-PIHC-FrICC/IFIF
抗体种类
Monoclonal
宿主来源Mouse
亚细胞定位Nucleus. Cytoplasm. Predominantly cytoplasmic in unliganded form but translocates to the nucleus upon ligand-binding. Can also translocate to the nucleus in unliganded form in the presence of GNB2L1.
组织特异性Isoform 2 is mainly expressed in heart and skeletal muscle.
构建方式Hybridoma Monoclonal Antibody
纯化方式Protein G purified
性状Liquid
缓冲液0.01M PBS (pH7.4) with 1% BSA and 0.02% Proclin300.
研究背景The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
抗原信息
免疫原
Recombinant Protein: human human Androgen Receptor
抗原种属
Human
基因名称
AR
基因ID
367
蛋白名称
Androgen receptor
Uniprot ID
P10275
功能
Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3.
化学信息
分子量Theoretical: 101 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 12 months, do not freeze.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

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