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Anti-ACOD1 Polyclonal Antibody
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产品编号 TMAB-00038
别名 IRG1, Immune-responsive gene 1 protein, Cis-aconitic acid decarboxylase, Cis-aconitate decarboxylase, CAD, Aconitate decarboxylase 1, Aconitate decarboxylase, ACOD1
Anti-ACOD1 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 ACOD1。Anti-ACOD1 Polyclonal Antibody 可用于 IHC-P,IHC-Fr,ICC/IF,IF,ELISA。
Anti-ACOD1 Polyclonal Antibody
Anti-ACOD1 Polyclonal Antibody
还可以产品编号 TMAB-00038 别名 IRG1, Immune-responsive gene 1 protein, Cis-aconitic acid decarboxylase, Cis-aconitate decarboxylase, CAD, Aconitate decarboxylase 1, Aconitate decarboxylase, ACOD1
Anti-ACOD1 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 ACOD1。Anti-ACOD1 Polyclonal Antibody 可用于 IHC-P,IHC-Fr,ICC/IF,IF,ELISA。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,170 | 5日内发货 | |
| 100 μL | ¥ 1,965 | 5日内发货 | |
| 200 μL | ¥ 2,780 | 5日内发货 |
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| 产品描述 | Anti-ACOD1 Polyclonal Antibody is a Rabbit antibody targeting ACOD1. Anti-ACOD1 Polyclonal Antibody can be used in IHC-P,IHC-Fr,ICC/IF,IF,ELISA. |
| 别名 | IRG1, Immune-responsive gene 1 protein, Cis-aconitic acid decarboxylase, Cis-aconitate decarboxylase, CAD, Aconitate decarboxylase 1, Aconitate decarboxylase, ACOD1 |
| Ig Type | IgG |
| 交叉反应 | (predicted:Human) |
| 应用 | |
| 推荐剂量 | IHC-P: 1:100-500; IHC-Fr: 1:100-500; ICC/IF: 1:100-500; IF: 1:100-500; ELISA: 1:5000-10000 |
| 抗体种类 | Polyclonal |
| 宿主来源 | Rabbit |
| 亚细胞定位 | Mitochondrion |
| 组织特异性 | Expressed in LPS-tolerized macrophages (at protein level). Expressed in peripheral blood mononuclear cells (PBMCs), microglia and macrophage cells. |
| 构建方式 | Polyclonal Antibody |
| 纯化方式 | Protein A purified |
| 性状 | Liquid |
| 缓冲液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 浓度 | 1 mg/mL |
| 研究背景 | IRG1 is a 481 amino acid protein that belongs to the prpD family and is encoded by a gene which maps to human chromosome 13. Comprising nearly 4% of the human genome, chromosome 13 contains around 114 million base pairs and encodes over 400 genes. Chromosome 13 houses key tumor suppressor genes, including BRCA2 and RB1, which are associated with breast cancer susceptibility and retinoblastoma, respectively. Trisomy 13, also known as Patau syndrome, is deadly and the few who survive past one year suffer from permanent neurologic defects, difficulty eating and vulnerability to serious respiratory infections |
| 免疫原 | KLH conjugated synthetic peptide: human IRG1 |
| 抗原种属 | Human |
| 基因名称 | ACOD1 |
| 基因ID | |
| 蛋白名称 | Cis-aconitate decarboxylase |
| Uniprot ID | |
| 研究领域 | Interferons,TNF Superfamily,Macrophage / Inflamm.,Energy Metabolism,Energy Metabolism |
| 功能 | Involved in the inhibition of the inflammatory response. Acts as a negative regulator of the Toll-like receptors (TLRs)-mediated inflammatory innate response by stimulating the tumor necrosis factor alpha-induced protein TNFAIP3 expression via reactive oxygen species (ROS) in LPS-tolerized macrophages. Involved in antimicrobial response of innate immune cells; IRG1-mediated itaconic acid production contributes to the antimicrobial activity of macrophages. Plays a role in the embryo implantation. |
| 分子量 | Theoretical: 53 kDa. |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
计算器
比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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