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Anti-53BP1 Antibody (3K586)
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产品编号 TMAC-00030
别名 Tumor suppressor p53 binding protein 1, Tumor protein p53 binding protein 1, tumor protein 53-binding protein, 1, Tumor protein 53 binding protein 1, TP53BP1, TP53B, TP53 BP1, p53 BP1, p53 binding protein 1, p202, MGC138366, FLJ41424, 53 BP1
Anti-53BP1 Antibody (3K586) 是一种 Rabbit 抗体，靶向 53BP1。Anti-53BP1 Antibody (3K586) 可用于 WB,ICC/IF,IHC,FCM。
Anti-53BP1 Antibody (3K586)
Anti-53BP1 Antibody (3K586)
还可以产品编号 TMAC-00030 别名 Tumor suppressor p53 binding protein 1, Tumor protein p53 binding protein 1, tumor protein 53-binding protein, 1, Tumor protein 53 binding protein 1, TP53BP1, TP53B, TP53 BP1, p53 BP1, p53 binding protein 1, p202, MGC138366, FLJ41424, 53 BP1
Anti-53BP1 Antibody (3K586) 是一种 Rabbit 抗体，靶向 53BP1。Anti-53BP1 Antibody (3K586) 可用于 WB,ICC/IF,IHC,FCM。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,495 | 5日内发货 | |
| 100 μL | ¥ 2,495 | 5日内发货 |
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偶联与修饰
抗原信息
化学信息
| 产品描述 | Anti-53BP1 Antibody (3K586) is a Rabbit antibody targeting 53BP1. Anti-53BP1 Antibody (3K586) can be used in WB,ICC/IF,IHC,FCM. |
| 别名 | Tumor suppressor p53 binding protein 1, Tumor protein p53 binding protein 1, tumor protein 53-binding protein, 1, Tumor protein 53 binding protein 1, TP53BP1, TP53B, TP53 BP1, p53 BP1, p53 binding protein 1, p202, MGC138366, FLJ41424, 53 BP1 |
| Ig Type | IgG |
| 交叉反应 | Human,Mouse,Rat |
| 验证活性 | 1. Immunohistochemical analysis of paraffin-embedded human spleen tissue using anti-53BP1 antibody. Counter stained with hematoxylin. 2. Immunohistochemical analysis of paraffin-embedded human liver tissue using anti-53BP1 antibody. Counter stained with hematoxylin. 3. Immunohistochemical analysis of paraffin-embedded human liver cancer tissue using anti-53BP1 antibody. Counter stained with hematoxylin. 4. Immunohistochemical analysis of paraffin-embedded human cervix tissue using anti-53BP1 antibody. Counter stained with hematoxylin. 5. Immunohistochemical analysis of paraffin-embedded mouse spleen tissue using anti-53BP1 antibody. Counter stained with hematoxylin. 6. ICC staining 53BP1 in HepG2 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 7. ICC staining 53BP1 in 293T cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 8. ICC staining 53BP1 in Hela cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 9. Flow cytometric analysis of Hela cells with 53BP1 antibody at 1/50 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black). Alexa Fluor 488-conjugated goat anti rabbit IgG was used as the secondary antibody. |
| 应用 | |
| 推荐剂量 | WB: 1:500-1000; IHC: 1:50-200; ICC/IF: 1:100-500; FCM: 1:50-100 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | Recombinant Antibody |
| 纯化方式 | ProA affinity purified |
| 性状 | Liquid |
| 缓冲液 | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| 研究背景 | The p53 binding proteins 53BP1 and 53BP2 (Bbp) bind to the central DNA-binding domain of wild type p53, but do not bind mutant p53. The central DNA-binding domain of p53 is required for site-specific DNA binding and is frequently mutated in malignant tumors. Binding of 53BP1 to the L3 loop of p53 and of 53BP2 to the L2 loop of p53 confirms that the loop is dependent on p53 conformation. Site-specific binding also suggests that 53BP1 and 53BP2 are involved in p53-mediated tumor suppression. 53BP1 was isolated from H258 cells and is expressed in Jurkat cells in both the cytoplasm and the nucleus. The N-terminus of 53BP2 is localized to the cytoplasm, while the C-terminus might be localized in the nucleus. 53BP1 promotes cell proliferation by binding to p202, whereas 53BP2 induces cell death by binding to Bcl2 and NFkB p65. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Protein |
| Uniprot ID |
| 分子量 | Theoretical: 214 kDa. |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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