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Anti-15-PGDH Antibody-FITC (4Z123)
还可以产品编号 TMAY-01750F
Anti-15-PGDH Antibody-FITC (4Z123) 是一种 FITC-conjugated Rabbit 抗体，靶向 15-PGDH。Anti-15-PGDH Antibody-FITC (4Z123) 可用于 FCM。
Anti-15-PGDH Antibody-FITC (4Z123)
Anti-15-PGDH Antibody-FITC (4Z123)
还可以产品编号 TMAY-01750F
Anti-15-PGDH Antibody-FITC (4Z123) 是一种 FITC-conjugated Rabbit 抗体，靶向 15-PGDH。Anti-15-PGDH Antibody-FITC (4Z123) 可用于 FCM。
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偶联与修饰
抗原信息
| 产品描述 | Anti-15-PGDH Antibody-FITC (4Z123) is a FITC-conjugated Rabbit antibody targeting 15-PGDH. Anti-15-PGDH Antibody-FITC (4Z123) can be used in FCM. |
| Ig Type | Monoclonal Rabbit IgG |
| 克隆号 | 4Z123 |
| 交叉反应 | Human |
| 验证活性 | Human HPGD expression in Jurkat cells. |
| 应用 | FCM |
| 推荐剂量 | 5 μl/Test, 0.1 mg/ml |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | This antibody was obtained from a rabbit immunized with purified, recombinant Human HPGD / 15-PGDH (rh HPGD / 15-PGDH; TMPY-01264; NP_000851.2; Met1-Gln266) and conjugated with FITC under optimum conditions, the unreacted FITC was removed. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | PBS solution containing 0.5% BSA and 0.09% sodium azide |
| 研究背景 | 15-hydroxyprostaglandin dehydrogenase [NAD+], also known as Prostaglandin dehydrogenase 1, HPGD, and PGDH1, is a member of the short-chain dehydrogenases/reductases (SDR) family. Prostaglandins (PGs) play a key role in the onset of labor in many species and regulate uterine contractility and cervical dilatation. Therefore, the regulation of prostaglandin output by PG synthesizing and metabolizing enzymes in the human myometrium may determine uterine activity patterns in human labor both at preterm and at term. Prostaglandin dehydrogenase (PGDH) metabolizes prostaglandins (PGs) to render them inactive. HPGD is down-regulated by cortisol, dexamethasone, and betamethasone and down-regulated in colon cancer. It is up-regulated by TGFB1. HPGD contributes to the regulation of events that are under the control of prostaglandin levels. HPGD catalyzes the NAD-dependent dehydrogenation of lipoxin A4 to form 15-oxo-lipoxin A4. and inhibits in vivo proliferation of colon cancer cells. Defects in HPGD are the cause of primary hypertrophic osteoarthropathy autosomal recessive (PHOAR), cranio-osteoarthropathy (COA), and isolated congenital nail clubbing. |
| 偶联 | FITC |
| 其他可选修饰符 | Unconjugated |
| 可提供抗体种类 | 2 |
| 免疫原 | Recombinant Human HPGD / 15-PGDH protein (TMPY-01264) |
| 抗原种属 | Human |
存储&运输
| 储存方式 | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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