Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Acloproxalap 是一种基于喹啉的醛清除剂,可用于研究有毒醛积累的疾病,如眼部、皮肤等炎症性疾病,肺炎等呼吸系统疾病,器官疾病以及病毒感染相关性综合症等。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
2 mg | ¥ 397 | 5日内发货 | ||
5 mg | ¥ 663 | 5日内发货 | ||
10 mg | ¥ 1,240 | 5日内发货 |
产品描述 | Acloproxalap is a quinoline-based aldehyde scavenger that can be used in studies of diseases with toxic aldehyde accumulation, such as inflammatory diseases of the eye and skin, respiratory diseases such as pneumonia, organ diseases, and syndromes associated with viral infections[1] [2]. |
体内活性 | Acloproxalap (compound I-6) (100 or 200 mg/kg, i.p. or p.o., everyday, 6 days) can effectively ameliorate inflammation of the colon in acute ulcerative colitis (UC) female Swiss Webster mice [1]. Animal Model: Acute ulcerative colitis (UC) in female Swiss Webster mice [1] Dosage: 100 mg/kg, 200 mg/kg Administration: Intraperitoneal injection for 100 mg/kg, oral gavage for 200 mg/kg; everyday; 6 days Result: Inhibited weight loss in intraperitoneal injection mice significantly while there was no significant difference in the oral gavage group compared to the control group. Both significantly reduced colonic histopathological parameters. Animal Model: Male non-na ve beagle dogs [2] Dosage: 3 mg/kg Administration: Intravenous injection; once Result: The pharmacokinetic parameters of Acloproxalap (compound I-1) Parameter Acloproxalap (compound I-1) t 1/2 1.82 h T max 0.518 h Clearance 12.2 mL/kg/min steady-state volume 1385 mL/kg AUC 0-t 4103 ng/mL*h AUC 0 inf_obs 4137 ng/mL*h Animal Model: Male non-na ve beagle dogs [2] Dosage: 10 mg/kg Administration: Oral gavage; once Result: The pharmacokinetic parameters of Acloproxalap (compound I-1) Parameter Acloproxalap (compound I-1) t 1/2 3.02 h T max 0.518 h C max 3558 ng/mL AUC 0-t 9361 ng/mL*h AUC 0 inf_obs 9546 ng/mL*h BioA 75% |
分子量 | 202.25 |
分子式 | C12H14N2O |
CAS No. | 1824609-67-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Acloproxalap 1824609-67-7 Inhibitor inhibitor inhibit