Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ximelagatran (H 376-95) 是一种口服活性凝血酶抑制剂,可选择性的、竞争性的抑制游离和凝块结合的凝血酶。它是一种抗凝药物,具有快速起效的抗凝作用,可预测的,剂量依赖性的药代动力学和药效学。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 619 | 现货 | ||
5 mg | ¥ 1,230 | 现货 | ||
10 mg | ¥ 2,150 | 现货 | ||
25 mg | ¥ 3,730 | 现货 | ||
50 mg | ¥ 4,970 | 现货 | ||
100 mg | ¥ 6,550 | 现货 | ||
200 mg | ¥ 8,830 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 1,290 | 现货 |
产品描述 | Ximelagatran (H 376-95), a direct thrombin inhibitor, can be taken orally and acts solely by inhibiting the actions of thrombin. Ximelagatran is converted to the active agent melagatran in vivo. |
体外活性 | Ximelagatran is an orally administered direct thrombin inhibitor under development as an anticoagulant agent for prophylaxis against and treatment of thromboembolism. Ximelagatran is rapidly absorbed and quickly converted into its active form Melagatran which is a reversible, active-site inhibitor of both free and clot-bound thrombin that has stable and reproducible pharmacokinetic properties. Initial studies have shown Ximelagatran to have good efficacy and safety in the prevention of venous thromboembolism after total knee or total hip replacement[1]. |
别名 | EXANTA, H 376-95, H37695, 希美加群, H 376/95, H-37695, H 37695 |
分子量 | 473.57 |
分子式 | C24H35N5O5 |
CAS No. | 192939-46-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 55 mg/ml (116.14 mM)
H2O: Insoluble
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.1116 mL | 10.5581 mL | 21.1162 mL | 52.7905 mL |
5 mM | 0.4223 mL | 2.1116 mL | 4.2232 mL | 10.5581 mL | |
10 mM | 0.2112 mL | 1.0558 mL | 2.1116 mL | 5.2791 mL | |
20 mM | 0.1056 mL | 0.5279 mL | 1.0558 mL | 2.6395 mL | |
50 mM | 0.0422 mL | 0.2112 mL | 0.4223 mL | 1.0558 mL | |
100 mM | 0.0211 mL | 0.1056 mL | 0.2112 mL | 0.5279 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Ximelagatran 192939-46-1 Proteases/Proteasome Thrombin EXANTA H 376-95 Inhibitor inhibit H37695 希美加群 H 376/95 H-37695 H 37695 inhibitor