规格

价格

库存

数量

1 mg

¥ 477

现货

5 mg

¥ 1,160

现货

10 mg

¥ 1,860

现货

25 mg

¥ 3,390

现货

50 mg

¥ 4,850

现货

100 mg

¥ 6,730

现货

500 mg

¥ 13,500

现货

1 mL x 10 mM (in DMSO)

¥ 1,350

现货

生物活性

产品描述	Allitinib (AST-1306) (AST-1306) has anti-cancer activity，and it is an irreversible EGFR and ErbB2 inhibitor with IC50s of 0.5 and 3 nM, respectively. [1]
靶点活性	ERB4:0.8 nM, EGFR (L858R/T790M):12 nM, ErbB2:3 nM, EGFR:0.5 nM
体外活性	AST1306 (AST-1306; 0.19-6.25 μM; 72 hours) inhibit the growth of HIH3T3-EGFR T790M/L858R cells[1]. AST1306 (0.001-1.0 μM; 4 hours) is more than 3000-fold selective for ErbB family kinases over other kinase families[1]. AST1306 inhibits the activation of tyrosine kinases and downstream signaling pathways in A549 cells, Calu-3 cells and SK-OV-3 cells，and dose-dependently and markedly inhibits EGF-induced EGFR phosphorylation in A549 cells[1].
体内活性	AST1306 (AST-1306; oral; 25-100 mg/kg) significantly inhibited tumor growth in SK-OV-3 and Calu-3 xenograft models[1].
别名	AST-1306, ALS 1306

化学信息

分子量	448.88
分子式	C₂₄H₁₈ClFN₄O₂
CAS No.	897383-62-9
Smiles	N(C=1C2=C(C=CC(NC(C=C)=O)=C2)N=CN1)C3=CC(Cl)=C(OCC4=CC(F)=CC=C4)C=C3
密度	1.395 g/cm3
颜色	Yellow
物理性状	Solid

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 55 mg/mL (122.53 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.46 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO