3-Acetylcoumarin

Name: 3-Acetylcoumarin
Brand: TargetMol
SKU: Fr12596
Price: 99 CNY
Availability: InStock
Rating: 5 (10 reviews)

一键复制产品信息

很棒

纯度: 99.31%

货号 Fr12596Cas号 3949-36-8

别名 3-乙酰基羟基香豆素

3-Acetylcoumarin 作为室温下铜催化 CN 偶联反应的实用配体。它具有神经保护和杀螨特性。

3-Acetylcoumarin

一键复制产品信息

很棒

纯度: 99.31%

货号 Fr12596 别名 3-乙酰基羟基香豆素Cas号 3949-36-8

3-Acetylcoumarin 作为室温下铜催化 CN 偶联反应的实用配体。它具有神经保护和杀螨特性。

规格	价格	库存	数量
500 mg	¥ 99	现货
1 mL x 10 mM (in DMSO)	¥ 149	现货

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COA HNMR LCMS 产品操作手册

产品介绍

3-Acetylcoumarin AI Summary

3-Acetylcoumarin demonstrates a variety of bioactivities across multiple biological systems. It induces NAD(P)H quinone reductase activity in Hepa 1c1c7 murine hepatoma cells at a concentration of 200.0 µM, suggesting antioxidant properties. The compound exhibits DPPH radical scavenging activity of 0.83% at 25 µg/mL after 30 minutes and shows ABTS free radical inhibition by 63.58%. Moreover, it inhibits rat intestinal alpha-glucosidase by 53.19% at 100 µg/mL and displays inhibitory activity against Human Jumonji Domain Containing 2E (JMJD2E) with a potency of 10,000.0 nM. Additionally, 3-Acetylcoumarin acts in a cytochrome panel assay with an AC50 of 199.53 nM and inhibits human recombinant MAO-B with an IC50 value of 14,450.0 nM, showing selectivity over MAO-A. In cancer research, it inhibits growth in various human tumor cell lines with GI50 values between 36,224.3 nM and 100,000.0 nM across different cancer types such as breast, melanoma, lung, prostate, colon, leukemia, central nervous system, ovarian, and renal cells. The compound also protects against pesticide-induced gastric lesions in Swiss albino mice, reducing lesions by 66.0% at a dose of 20 mg/kg orally. It shows moderate inhibitory activity against human CA9 with a Ki value of 151.8 nM and strong inhibitory activity against human CA12 with a Ki value of 7.8 nM. 3-Acetylcoumarin also inhibits the aggregation of HFIP-induced amyloid beta (1-42 residues), with inhibition rates between 40.0% to 59.0%, as measured by ThT fluorescence and turbidity assays. It demonstrates cytotoxicity against human SH-SY5Y cells with an IC50 of 75,000.0 nM and neuroprotective effects against amyloid beta-induced toxicity in the same cells with an activity level of 77.0%. Additionally, the compound shows antiviral activity against SARS-CoV-2 in VERO-6 cells, although with an IC50 value greater than 20,000.0 nM, it may not be highly potent in this assay..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	3-Acetylcoumarin as a practical ligand for copper-catalyzed CN coupling reactions at room temperature. It has neuroprotective and acaricidal properties.
别名	3-乙酰基羟基香豆素

化学信息

分子量	188.18
分子式	C₁₁H₈O₃
CAS No.	3949-36-8
Smiles	CC(=O)c1cc2ccccc2oc1=O
密度	1.285g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 25 mg/mL (132.85 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.3141 mL	26.5703 mL	53.1406 mL	265.7031 mL
5 mM	1.0628 mL	5.3141 mL	10.6281 mL	53.1406 mL
10 mM	0.5314 mL	2.6570 mL	5.3141 mL	26.5703 mL
20 mM	0.2657 mL	1.3285 mL	2.6570 mL	13.2852 mL
50 mM	0.1063 mL	0.5314 mL	1.0628 mL	5.3141 mL
100 mM	0.0531 mL	0.2657 mL	0.5314 mL	2.6570 mL