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2-(2-Hydroxyphenyl)-1H-benzimidazole

Name: 2-(2-Hydroxyphenyl)-1H-benzimidazole
Brand: TargetMol
SKU: T9152
Price: 99 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.6%

货号 T9152Cas号 2963-66-8

别名 2-(2-羟苯基)苯并咪唑

2-(2-Hydroxyphenyl)-1H-benzimidazole 已被用于合成聚合物和其他材料的催化剂。

2-(2-Hydroxyphenyl)-1H-benzimidazole

一键复制产品信息

很棒

纯度: 99.6%

货号 T9152 别名 2-(2-羟苯基)苯并咪唑Cas号 2963-66-8

2-(2-Hydroxyphenyl)-1H-benzimidazole 已被用于合成聚合物和其他材料的催化剂。

规格	价格	库存	数量
200 mg	¥ 99	现货
1 mL x 10 mM (in DMSO)	¥ 99	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

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产品介绍

2-(2-Hydroxyphenyl)-1H-benzimidazole AI Summary

2-(2-Hydroxyphenyl)-1H-benzimidazole exhibits a multifaceted biological activity profile. It shows moderate to weak inhibition of Co2+-loaded MetAP expressed in _Escherichia coli_, with a 30.37% inhibition at 10 μM and an IC50 value greater than 10000 nM, and also targets MetAP in _Staphylococcus aureus_ and human MetAP2, with inhibition percentages of 66.0%, 12.0%, and 18.0% at 25 μM, respectively. The compound has significant spasmolytic activity in Wistar rat ileum, achieving an Emax of 42.4% and an IC50 of 5150 nM, and a potency index of 1.13 relative to gigantol. 2-(2-Hydroxyphenyl)-1H-benzimidazole inhibits the relaxation of supercoiled plasmid DNA by calf thymus DNA topoisomerase 1 by 95.4% and displays varying levels of cytotoxicity against human A431, HeLa, and MCF7 cells with IC50 values of 30000 nM, 26450 nM, and 16030 nM, respectively, over 72 hours in MTT assays. It also shows antibacterial activity, notably against _Bacillus cereus_ with a MIC of 6.25 μg/mL, and moderate effectiveness against _Pseudomonas aeruginosa_ and _Staphylococcus aureus_ with MIC values of 25.0 μg/mL, but lower activity against other strains like _Salmonella enterica_ and _Escherichia coli_ with MIC values of 400.0 μg/mL. For _Escherichia coli_, it demonstrates an MIC of 25,000 nM, while other strains like _Bacillus cereus_ have MIC values greater than 200,000 nM. The compound shows no cytotoxicity against mouse NIH/3T3 cells (IC50 > 200,000 nM) and moderate antioxidant activity against superoxide radical anions (EC50 122,000 nM), while displaying minimal activity in DPPH radical scavenging (EC50 > 200,000 nM). Additionally, it inhibits human IDO1 activity by 1.0% at 400 μM. Furthermore, antiproliferative activity is observed against human U251MG, IN1528, and IN1760 cells, with EC50 values of 23000 nM, 25000 nM, and 36000 nM, respectively, using the SRB assay over 72 hours..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	2-(2-Hydroxyphenyl)-1H-benzimidazole has been used as a catalyst for the synthesis of polymers and other materials.
别名	2-(2-羟苯基)苯并咪唑

化学信息

分子量	210.23
分子式	C₁₃H₁₀N₂O
CAS No.	2963-66-8
Smiles	Oc1ccccc1-c1nc2ccccc2[nH]1
密度	1.323 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 65 mg/mL (309.19 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (9.51 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.7567 mL	23.7835 mL	47.5670 mL	237.8348 mL
5 mM	0.9513 mL	4.7567 mL	9.5134 mL	47.5670 mL
10 mM	0.4757 mL	2.3783 mL	4.7567 mL	23.7835 mL
20 mM	0.2378 mL	1.1892 mL	2.3783 mL	11.8917 mL
50 mM	0.0951 mL	0.4757 mL	0.9513 mL	4.7567 mL
100 mM	0.0476 mL	0.2378 mL	0.4757 mL	2.3783 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法： 取 100 μL DMSO 母液，添加 400 μL PEG300 混匀澄清，再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH₂O 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

关键词

2-(2-Hydroxyphenyl)-1H-benzimidazole 2(2Hydroxyphenyl)1Hbenzimidazole 2 (2 Hydroxyphenyl) 1H benzimidazole

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2-(2-Hydroxyphenyl)-1H-benzimidazole

2-(2-Hydroxyphenyl)-1H-benzimidazole