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PAFR

PAFR

The platelet-activating factor receptor is a G-protein coupled receptor which binds platelet-activating factor. The PAF receptor shows structural characteristics of the rhodopsin (MIM 180380) gene family and binds platelet-activating factor (PAF). PAF is a phospholipid (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) that has been implicated as a mediator in diverse pathologic processes, such as allergy, asthma, septic shock, arterial thrombosis, and inflammatory processes.[supplied by OMIM][7] Its pathogenetic role in chronic kidney failure has also been reported recently.
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Cat. No. Product Name CAS No. Purity Chemical Structure
TN4367 Kadsurin A
化合物Kadsurin A
99340-07-5 98%
Kadsurin A 具有抗血小板活化因子活性。
T6242 Rupatadine Fumarate
富马酸卢帕他定
182349-12-8 99.99%
Rupatadine Fumarate 是一种可口服的长效PAF/H1受体的双抑制剂,Ki值分别为 0.55 μM 和 0.1 μM。它可研究过敏性鼻炎和荨麻疹。
TN4660 Niranthin
珠子草素
50656-77-4 99.8%
Niranthin 是一种木脂素,具有广泛的药理活性。它是L. donovaniIB 拓扑异构酶的非竞争性抑制剂,可用于研究耐药利什曼病的治疗。
T2751 Ginkgolide B
银杏内酯B
15291-77-7 99.77%
Ginkgolide B 是一种萜类物质,是银杏叶中的重要的活性物质之一。
TN3831 (-)-Denudatin B
化合物Denudatin B
87402-88-8 97.45%
(-)-Denudatin B 源自 Magnolia fargesii。 (-)-Denudatin B 通过抑制胶原蛋白和凝血酶诱导的磷酸肌醇分解,在高浓度下具有非特异性抗血小板作用。
TN2322 Yangambin
鹅掌楸树脂酚B二甲醚
13060-14-5
Yangambin 是从诸如番荔枝科植物中分离出来的呋喃木脂素,是选择性PAF受体拮抗剂,通过调控Ca2+通道抑制 Ca2+流入,导致 [Ca2+]i在血管平滑肌细胞和随后的外周血管舒张中减少,具有降压作用。
TN1643 Ferulamide
阿魏酸酰胺
61012-31-5 98%
Ferulamide 是从巴豆中分离的阿魏酸衍生物,具有抗胆碱酯酶活性。
TN1271 Scutellarein tetramethyl ether
黄芩四甲基醚
1168-42-9 98%
Scutellarein tetramethyl ether 从暹罗草中提取,通过 NF-κB 途径表现出抗炎活性。
TN2329 Zingiberen newsaponin
盾叶新苷
91653-50-8 98%
Zingiberen Newsaponin 是分离自盾叶薯 (Dioscorea zingiberensis) 中。 它能够诱导血小板聚集。
TN1254 3'-Methoxydaidzein
化合物3'-Methoxydaidzein
21913-98-4 98%
3'-Methoxydaidzein has antioxidant activity, it and geraldol have antiplatelet aggregation activity and appear to be specific against collagen induce platelet a...
TN2086 Piperlotine A
化合物Piperlotine A
389572-70-7 98%
Piperlotine A shows potent antiplatelet aggregation activity.
TMA2418 1-Methoxyphaseollidin
化合物 TMA2418
65428-13-9 98%
1-Methoxyphaseollidin exhibits anti-Helicobacter pylori activity against the CLAR and AMOX-resistant strain as well as four CLAR (AMOX)-sensitive strains. 1-Meth...
TN1715 Guaiacin
愈创木素
36531-08-5 98%
(+)-Guaiacin has significant neuroprotective, and anti-inflammatory activities, it can inhibit cyclooxygenase (COX)-1 and COX-2.
TN5045 Spiradine F
化合物 TN5045
21040-64-2 98%
Spiradine F can significantly inhibit platelet-activating factor(PAF)-induced platelet aggregation in a concentration-dependent manner.
TN3740 Cyclocommunol
化合物 TN3740
145643-96-5 98%
Cyclocommunol exhibits cytotoxicity against hepatocellular carcinoma (SMMC-7721) and gastric carcinoma (BGC-823 and SGC-7901) cell lines. It also shows strong in...
TN3348 (+)-Acuminatin
化合物 TN3348
41744-39-2 98%
(-)-Acuminatin exerts hepatoprotective activities, perhaps by serving as a potent antioxidant. (+)-trans-Acuminatin, and (+)-cis-acuminatin show weak activity ag...
TN3153 6-Acetyl-2,2-dimethylchroman-4-one
化合物 TN3153
68799-41-7 98%
6-Acetyl-2,2-dimethylchroman-4-one and vanillin show anti-platelet aggregation activity induced by arachidonic acid in vitro.
TN4600 Myrianthic acid
化合物 TN4600
89786-84-5 98%
Myrianthic acid shows anticancer activity, it shows inhibitory activities on foam cell formation in human monocyte-derived macrophages induced by acetylated low-...
TN3723 Cryptomeridiol
化合物 TN3723
4666-84-6 98%
Cryptomeridiol is a potential skin-whitening agent, exhibits melanogenesis inhibitory activity on α-MSH-stimulated B16 melanoma cells. Cryptomeridiol has low act...
TN1654 Futoquinol
细叶青蒌藤醌醇
28178-92-9 98%
Futoquinol is an anti-platelet activating factor principle from the stem part of Piper futokadsura (Piperaceae), the Chinese drug haifengteng.
Kadsurin A
TN4367
Kadsurin A 具有抗血小板活化因子活性。
Rupatadine Fumarate
T6242
Rupatadine Fumarate 是一种可口服的长效PAF/H1受体的双抑制剂,Ki值分别为 0.55 μM 和 0.1 μM。它可研究过敏性鼻炎和荨麻疹。
Niranthin
TN4660
Niranthin 是一种木脂素,具有广泛的药理活性。它是L. donovaniIB 拓扑异构酶的非竞争性抑制剂,可用于研究耐药利什曼病的治疗。
Ginkgolide B
T2751
Ginkgolide B 是一种萜类物质,是银杏叶中的重要的活性物质之一。
(-)-Denudatin B
TN3831
(-)-Denudatin B 源自 Magnolia fargesii。 (-)-Denudatin B 通过抑制胶原蛋白和凝血酶诱导的磷酸肌醇分解,在高浓度下具有非特异性抗血小板作用。
Yangambin
TN2322
Yangambin 是从诸如番荔枝科植物中分离出来的呋喃木脂素,是选择性PAF受体拮抗剂,通过调控Ca2+通道抑制 Ca2+流入,导致 [Ca2+]i在血管平滑肌细胞和随后的外周血管舒张中减少,具有降压作用。
Ferulamide
TN1643
Ferulamide 是从巴豆中分离的阿魏酸衍生物,具有抗胆碱酯酶活性。
Scutellarein tetramethyl ether
TN1271
Scutellarein tetramethyl ether 从暹罗草中提取,通过 NF-κB 途径表现出抗炎活性。
Zingiberen newsaponin
TN2329
Zingiberen Newsaponin 是分离自盾叶薯 (Dioscorea zingiberensis) 中。 它能够诱导血小板聚集。
3'-Methoxydaidzein
TN1254
3'-Methoxydaidzein has antioxidant activity, it and geraldol have antiplatelet aggregation activity and appear to be specific against collagen induce platelet a...
Piperlotine A
TN2086
Piperlotine A shows potent antiplatelet aggregation activity.
1-Methoxyphaseollidin
TMA2418
1-Methoxyphaseollidin exhibits anti-Helicobacter pylori activity against the CLAR and AMOX-resistant strain as well as four CLAR (AMOX)-sensitive strains. 1-Meth...
Guaiacin
TN1715
(+)-Guaiacin has significant neuroprotective, and anti-inflammatory activities, it can inhibit cyclooxygenase (COX)-1 and COX-2.
Spiradine F
TN5045
Spiradine F can significantly inhibit platelet-activating factor(PAF)-induced platelet aggregation in a concentration-dependent manner.
Cyclocommunol
TN3740
Cyclocommunol exhibits cytotoxicity against hepatocellular carcinoma (SMMC-7721) and gastric carcinoma (BGC-823 and SGC-7901) cell lines. It also shows strong in...
(+)-Acuminatin
TN3348
(-)-Acuminatin exerts hepatoprotective activities, perhaps by serving as a potent antioxidant. (+)-trans-Acuminatin, and (+)-cis-acuminatin show weak activity ag...
6-Acetyl-2,2-dimethylchroman-4-one
TN3153
6-Acetyl-2,2-dimethylchroman-4-one and vanillin show anti-platelet aggregation activity induced by arachidonic acid in vitro.
Myrianthic acid
TN4600
Myrianthic acid shows anticancer activity, it shows inhibitory activities on foam cell formation in human monocyte-derived macrophages induced by acetylated low-...
Cryptomeridiol
TN3723
Cryptomeridiol is a potential skin-whitening agent, exhibits melanogenesis inhibitory activity on α-MSH-stimulated B16 melanoma cells. Cryptomeridiol has low act...
Futoquinol
TN1654
Futoquinol is an anti-platelet activating factor principle from the stem part of Piper futokadsura (Piperaceae), the Chinese drug haifengteng.
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