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12

抑制剂 & 化合物

7

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T2305	Isavuconazole 艾沙康唑,BAL-4815,RO-0094815	P450; Antibiotic; Antifungal	Metabolism; Microbiology/Virology
	Isavuconazole (RO-0094815) 是一种三唑类前药，对酵母、霉菌和二型真菌具有抗真菌活性。它抑制麦角固醇生物合成，导致真菌膜结构和功能的破坏。它是 CYP3A4抑制剂。
T1438	Butoconazole nitrate RS 35887,硝酸布康唑	Estrogen/progestogen Receptor; Antifungal	Endocrinology/Hormones; Microbiology/Virology
	Butoconazole nitrate (RS 35887) 是一种咪唑类抗真菌药物，可治疗由白色念珠菌引起的阴道感染。它可通过抑制类固醇合成起到抗菌作用。
T1543	Naftifine hydrochloride Naftifungin,盐酸萘替芬,Naftifine HCl,Naftin,Exoderil	Hedgehog/Smoothened; Antibiotic; Antifungal	GPCR/G Protein; Microbiology/Virology; Stem Cells
	Naftifine hydrochloride (Naftifine HCl) 是一种抗生素。它具有抗真菌活性，对皮肤真菌、曲霉、Sporothrix schenckii、假丝酵母属的酵母有抑制作用。
T25849	Naftoxate Naftoxatum,Naftoxato
	Naftoxate is an antimicotic. It is effective against both gram-positive and gram-negative bacteria as well as yeasts and other fungi in plant cell culture.
T68604	Piperazinomycin
	Piperazinomycin is an antifungal antibiotic, showing inhibitory activity against fungi and yeasts, especially against Trichophyton.
T68998	Parconazole Free Base
	Parconazole Free Base is used in veterinary as an oral fungicide with a broad-spectrum activity against dermatophytes, yeasts, and others fungi. This compound does not have any antibacterial effect. The mechanism of action involves inhibition of the fungal cytochrome P450 dependent 14alpha-dimethylation of lanosterol to ergosterol.
T71446	Kalafungin
	Kalafungin antimicrobial agent that is inhibitory in vitro against a variety of pathogenic fungi, yeasts, protozoa, gram-positive bacteria, and, to a lesser extent, gram-negative bacteria.
T69051	Aculeacin A
	Aculeacin A is used to study mutations that lead to antibiotic resistance in Saccharomyces cerevisiae, the inhibition of Candida albicans and the morphogenetic transformation of Candida albicans when treated. Aculeacin A is a lipopeptide that inhibits β-glucan synthesis in yeasts. The inhibition is due to the selective blockage of glucan synthase. Aculeacin A, an amphophilic antibiotic, inhibits the biosynthesis of β−glucan by selective blockage of β(1→3) glucan synthase.
T11679	Isavuconazole-d4 BAL-4815 D4,RO-0094815 D4,Isavuconazole D4	Others	Others
	Isavuconazole D4 is a deuterium labeled Isavuconazole. Isavuconazole is a triazole prodrug with antifungal activity against yeasts, molds, and dimorphic fungi.
T81018	Termicin
	Termicin，一种Pseudacanthotermes spiniger源抗菌肽，对革兰氏阳性菌、丝状真菌及酵母具有活性。
T8814	Nikkomycin Z 尼柯霉素Z,Nikkomycin Z from Streptomyces tendae,尼柯霉素 Z	Others; Antibiotic; Antifungal	Microbiology/Virology; Others
	Nikkomycin Z (Nikkomycin Z from Streptomyces tendae) 是一种选择性竞争性几丁质合成抑制剂。它是一种核苷肽，可作为几丁质合酶底物 UDP-N-乙酰氨基葡萄糖的竞争性类似物，具有抗真菌作用。
T4791	Idarubicin Demethoxydaunorubicin
	Idarubicin 是一种有效的、具有口服活性的蒽环类抗白血病剂。Idarubicin 抑制拓扑异构酶 II，干扰 DNA 复制和 RNA 转录。Idarubicin 可诱导 DNA 损伤。Idarubicin 抑制 DNA 合成和 c-myc 表达。Idarubicin 还抑制细菌和酵母菌的生长。

化合物

Cat.No: T2305

Synonym: 艾沙康唑,BAL-4815,RO-0094815

Target: P450, Antibiotic, Antifungal

Butoconazole nitrate

Cat.No: T1438

Synonym: RS 35887,硝酸布康唑

Target: Estrogen/progestogen Receptor, Antifungal

Naftifine hydrochloride

Cat.No: T1543

Synonym: Naftifungin,盐酸萘替芬,Naftifine HCl,Naftin,Exoderil

Target: Hedgehog/Smoothened, Antibiotic, Antifungal

Cat.No: T25849

Synonym: Naftoxatum,Naftoxato

Piperazinomycin

Cat.No: T68604

Parconazole Free Base

Cat.No: T68998

Cat.No: T71446

Cat.No: T69051

Isavuconazole-d4

Cat.No: T11679

Synonym: BAL-4815 D4,RO-0094815 D4,Isavuconazole D4

Target: Others

Cat.No: T81018

Cat.No: T8814

Synonym: 尼柯霉素Z,Nikkomycin Z from Streptomyces tendae,尼柯霉素 Z

Target: Others, Antibiotic, Antifungal

Cat.No: T4791

Synonym: Demethoxydaunorubicin

Cat. No.	Product Name	Target	Signaling Pathways
T8019	Sorbic acid	Anti-infection; Endogenous Metabolite; Antibacterial; Antibiotic; Antifungal	Metabolism; Microbiology/Virology
	Sorbic acid 是一种高效安全无毒的食品防腐剂。它可抑制大多数霉菌，酵母和某些细菌。
TN6163	3-O-cis-p-Coumaroylmaslinic acid
	3-beta-O-(trans-p-Coumaroyl)maslinic acid shows antimicrobial activity on Gram-positive bacteria and yeasts.
TN6148	3-O-trans-p-Coumaroylmaslinic acid
	3-beta-O-(trans-p-Coumaroyl)maslinic acid is a DNA polymerase B" inhibitor. It shows antimicrobial activity on Gram-positive bacteria and yeasts.
TN4280	Isodictamnine	Others	Others
	Isodictamnine is phototoxic to certain bacteria and yeasts in long wave UV light.
T38338	Quinolactacin A
	Quinolactactin A is a quinolone fungal metabolite originally isolated from Penicillium. It inhibits TNF production induced by LPS in murine peritoneal macrophages (IC50 = 12.2 μg/ml). It is not active against a variety of bacteria, fungi, and yeasts. Quinolactacin A is a mixture of quinolactacin A1 and A2.
T75686	Enfumafungin
	Enfumafungin，一种从Hormonema carpetanum菌提取的三萜糖苷，具有抗真菌特性，主要通过作为(1,3)-beta-D-葡聚糖合酶抑制剂影响真菌细胞壁发挥作用。其对酵母和多数真菌（除隐球菌外）有效，但不会抑制枯草芽孢杆菌的生长。
T35624	Ajoene
	Ajoene is a disulfide that has been found inA. sativumand has diverse biological activities, including antibacterial, anticancer, antiplatelet, and antioxidant properties.1,2,3,4It is active against Gram-positive (MICs = 5-160 &#181g/ml) and Gram-negative bacteria (MICs = 136-200 &#181g/ml), as well as yeasts (MICs = 10-20 &#181g/ml).1Ajoene is cytotoxic to mouse melanoma cells (IC50= 18 &#181M), as well as human colon, lung, mammary, and pancreatic cancer cells (IC50s = 7-41 &#181M).2It reduces...

天然产物

Cat.No: T8019

Target: Anti-infection, Endogenous Metabolite, Antibacterial, Antibiotic, Antifungal

3-O-cis-p-Coumaroylmaslinic acid

Cat.No: TN6163

3-O-trans-p-Coumaroylmaslinic acid

Cat.No: TN6148

Cat.No: TN4280

Target: Others

Quinolactacin A

Cat.No: T38338

Cat.No: T75686

Cat.No: T35624

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