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Search Results for " trans-isomer "

22

抑制剂 & 化合物

5

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T6183	ISRIB (trans-isomer) ISRIB,ISRIB trans-isomer,trans-isomer,trans-ISRIB	Apoptosis; PERK; Autophagy	Apoptosis; Autophagy
	ISRIB (trans-isomer) (ISRIB trans-isomer)是一种 PERK 的高效抑制剂，可有效逆转 eIF2α 磷酸化的作用，IC50值为 5 nM。
T0835	Tamoxifen Citrate Tamoxifen Z-isomer citrate,ICI 46474,ICI 46474 Citrate,枸橼酸他莫昔芬,他莫昔芬柠檬酸盐	Apoptosis; Estrogen Receptor/ERR; HSP; Estrogen/progestogen Receptor; Autophagy	Apoptosis; Autophagy; Cytoskeletal Signaling; Endocrinology/Hormones; Metabolism
	Tamoxifen Citrate 是一种口服有效的，选择性雌激素受体调节剂，可阻断乳腺细胞中的雌激素作用，并可激活如骨骼、肝脏和子宫细胞中的雌激素活性。它是 Hsp90激活剂，可增强 Hsp90 分子伴侣 ATPase 的活性，可激活自噬和诱导凋亡。
T25509	HW 173 HW173,HW-173
	HW 173 exhibits a specific affinity for sigma receptors. It is the (trans)-isomer.
T34150	Proparthrin Kikuthrin
	Proparthrin, a trans isomer of the chrysanthemumate ester of primary alcohols, is an insectide
T13197	trans-Doxercalciferol	Others	Others
	trans-Doxercalciferol is an isomer of Doxercalciferol. Doxercalciferol is an activator of the Vitamin D receptor and prevents renal disease.
T70357	CM-546
	CM-546 is the trans-isomer of CM-414, and a dual inhibitor of PDE5 and HDACs.
T13415	Zuclomiphene citrate	Others	Others
	Zuclomiphene citrate is a cis isomer of Clomiphene citrate, and has an antiestrogenic effect and can inhibit the secretion of luteinizing hormone (LH) more than the trans isomer.
T37213	5-trans Latanoprost
	Latanoprost is an F-series prostaglandin analog which has been approved for use as an ocular hypotensive drug. 5-trans Latanoprost is an isomer of latanoprost wherein the double bond between carbons 5 and 6 has been changed from cis (Z) to trans (E). The trans isomer of latanoprost occurs as an impurity of between 2-5% in most commercial preparations of the bulk drug product. The present compound was prepared primarily as an analytical standard for detection and quantitation of this impurity. Fr...
T37214	5-trans Latanoprost (free acid)
	Latanoprost is an F-series prostaglandin (PG) analog which has been approved for use as an ocular hypotensive drug. Latanoprost is an isopropyl ester, a prodrug form which is converted to latanoprost (free acid) by endogenous esterase enzymes. The free acid form is 200 times more potent than latanoprost as a ligand for the human recombinant FP receptor. 5-trans Latanoprost (free acid) is an isomer of latanoprost (free acid) wherein the double bond between carbons 5 and 6 has been changed from ci...
T74028	(Z)-2-Octenoic acid
	Z-2-Octenoic acid为2-Octenoic acid的Z-异构体，同时，trans-2-Octenoic acid为Mucor species的代谢产物。
T37493	11-trans Leukotriene D4 11-trans Leukotriene D4
	11-trans Leukotriene D4 (11-trans LTD4) is a C-11 double bond isomer of LTD4. LTD4 undergoes slow temperature-dependent isomerization to 11-trans LTD4 during storage. 11-trans LTD4 retains about 10-25 % of the potency for contraction of guinea pig ileum, trachea and parenchyma compared to LTD4. It exhibits an ED50 ranging between 12-60 nM for contraction of guinea pig trachea.
T37230	(+)-5-trans Cloprostenol
	Cloprostenol is a synthetic derivative of prostaglandin F2α that is used in veterinary medicine as a luteolytic agent for the induction of estrus and in the treatment of reproductive disorders in cattle, swine, and horses. (+)-5-trans Cloprostenol is a minor impurity produced in the synthesis of (+)-cloprostenol. The (+)-5-trans isomer is 20-fold less active than the 5-cis form in terminating pregnancy in the hamster.
T37651	5(S),6(R)-11-trans DiHETE
	5(S),6(R)-11-trans DiHETE is a C-11 double bond isomer of 5(S),6(R)-DiHETE that is formed by the enzymatic isomerization of 5(S),6(R)-DiHETE by a membrane bound factor. 5(S),6(R)-11-trans DiHETE has been found in rat kidney homogenates and is potentially formed by the epoxide hydrolase pathway in this tissue. The isomerase activity responsible for the conversion of leukotriene B4 (LTB4) to 6-trans LTB4 in rat kidney homogenates has also been implicated in its formation. 5(S),6(R)-11-trans DiHETE...
T37492	11-trans Leukotriene C4 11-trans Leukotriene C4
	11-trans Leukotriene C4 (11-trans LTC4) is a C-11 double bond isomer of LTC4. LTC4 undergoes slow temperature-dependent isomerization to 11-trans LTC4 during storage. 11-trans LTC4 is produced in smaller amounts relative to LTC4 in ionophore-stimulated HMC-1 cells (a human mast cell line) and equine eosinophils, but not in human neutrophils or RBL-1 cells. It is nearly equipotent with LTC4 for contraction of guinea pig parenchymal and ileum. In a radioligand binding assay using guinea pig ileum ...
T72436	cis,trans-Germacrone
	cis,trans-Germacrone 是 Germacrone 的异构体。Germacrone 具有广泛的抗肿瘤、抗氧化和抗炎作用。Germacrone 抑制肺癌细胞增殖并改变 Akt/MDM2/p53。Germacrone 还能在 G1/S 期阻滞细胞周期。
T37547	trans-Urocanic Acid
	trans-Urocanic acid is a major epidermal chromophore for the immunosuppressive effects of UV radiation that is produced in mammalian stratum corneum by the action of histidine ammonialyase on L-histidine. It contributes to the acidification of the surface of the stratum corneum, and its function has been proposed as that of an endogenous sunscreen, endowing a low-level of protection (SPF ~ 1.5) against UV-induced DNA damage and excessive keratinocyte apoptosis. Upon UVB exposure, trans-urocanic ...
T37970	12-epi Leukotriene B4 12-epi Leukotriene B4
	Leukotriene B4 (LTB4) compounds are produced by both enzymatic and non-enzymatic processes. The products of enzymatic origin, via Leukotriene A4 (LTA4) hydrolase, are stereospecifically 12(R). Non-enzymatic hydrolysis products are 50:50 mixtures at C-12, but are almost exclusively trans at C-6. Thus, the non-enzymatic hydrolysis product of LTA4 is 6-trans-12-epi LTB4. 12-epi LTB4 is an isomer which would not be expected to occur in either non-enzymatic hydrolysis products, or in the enzymatic pr...
T36765	Palmitelaidic Acid methyl ester
	Palmitoleic acid is a common constituent of the triglycerides of human adipose tissue. Palmitoleic acid-based diets raise low-density lipoprotein cholesterol and diminish high-density lipoprotein cholesterol, even when dietary intake of cholesterol is maintained at a low level. Palmitelaidic acid is the trans isomer of the 16:1 fatty acid palmitoleic acid. While its effects on cholesterol levels are poorly studied, palmitelaidic acid can have very different effects from those of palmitoleic acid...
T69682	AEW541 HCl
	AEW541, also known as NVP-AEW541, is a novel, potent IGF-IR kinase inhibitor. NVP-AEW541 is capable of distinguishing between the IGF-IR (IC50 = 0.086 microM) and the closely related InsR (IC50 = 2.3 microM) in cells. NVP- AEW541 abrogates IGF-I-mediated survival and colony formation in soft agar at concentrations that are consistent with inhibition of IGF-IR autophosphorylation. Note: AEW541 has a Cis-configuration on the cyclobutane ring. Its CAS# is 475489-16-8. Many vendors and Sc-finder sc...
T37305	6(S)-Lipoxin A4 6(S)-Lipoxin A4
	The lipoxins are trihydroxy fatty acids containing a 7,9,11,13-conjugated tetraene. Lipoxin A4 (LXA4) was first described as a metabolite of 15-HpETE and/or 15-HETE when added in vitro to isolated human leukocytes. The material obtained in this manner consists of at least four distinct isomers: 5(S), 6(S); 5(S), 6(R); and the 11-trans and 11-cis isomers of each of these. 6(S)-LXA4 is one of the original four metabolites first identified by Serhan, Nicolaou, and Samuelsson. It was considered to b...
T35854	9(Z),11(E)-Conjugated Linoleic Acid (sodium salt)
	9(Z),11(E)-Conjugated linoleic acid is an isomer of linoleic acid that has been found in beef and milk fat.1It binds to peroxisome proliferator-activated receptor α (PPARα; IC50= 140 nM) and activates the receptor in a reporter assay using COS-1 cells expressing mouse PPARα when used at a concentration of 100 μM.29(Z),11(E)-Conjugated linoleic acid inhibits TNF-α-inducedGLUT4expression and increases insulin-stimulated glucose transport in 3T3-L1 adipocytes.3Dietary administration of 9(Z)11(E)-co...
T36887	8(E),10(E),12(Z)-Octadecatrienoic Acid
	8(E),10(E),12(Z)-Octadecatrienoic acid is a conjugated polyunsaturated fatty acid (PUFA) that has been found inC. officinalisseed oil and has anticancer activity.1,2,3It inhibits the growth of Caco-2 cells when used at concentrations ranging from 10 to 50 μM.28(E),10(E),12(Z)-Octadecatrienoic acid (10 μM) induces formation of thiobarbituric acid reactive substances (TBARS) and apoptosis in DLD-1 colorectal adenocarcinoma cells.3It also inhibits prostaglandin biosynthesis in sheep vesicular gland...

化合物

ISRIB (trans-isomer)

Cat.No: T6183

Synonym: ISRIB,ISRIB trans-isomer,trans-isomer,trans-ISRIB

Target: Apoptosis, PERK, Autophagy

Tamoxifen Citrate

Cat.No: T0835

Synonym: Tamoxifen Z-isomer citrate,ICI 46474,ICI 46474 Citrate,枸橼酸他莫昔芬,他莫昔芬柠檬酸盐

Target: Apoptosis, Estrogen Receptor/ERR, HSP, Estrogen/progestogen Receptor, Autophagy

Cat.No: T25509

Synonym: HW173,HW-173

Cat.No: T34150

Synonym: Kikuthrin

trans-Doxercalciferol

Cat.No: T13197

Target: Others

Cat.No: T70357

Zuclomiphene citrate

Cat.No: T13415

Target: Others

5-trans Latanoprost

Cat.No: T37213

5-trans Latanoprost (free acid)

Cat.No: T37214

(Z)-2-Octenoic acid

Cat.No: T74028

11-trans Leukotriene D4

Cat.No: T37493

Synonym: 11-trans Leukotriene D4

(+)-5-trans Cloprostenol

Cat.No: T37230

5(S),6(R)-11-trans DiHETE

Cat.No: T37651

11-trans Leukotriene C4

Cat.No: T37492

Synonym: 11-trans Leukotriene C4

cis,trans-Germacrone

Cat.No: T72436

trans-Urocanic Acid

Cat.No: T37547

12-epi Leukotriene B4

Cat.No: T37970

Synonym: 12-epi Leukotriene B4

Palmitelaidic Acid methyl ester

Cat.No: T36765

Cat.No: T69682

6(S)-Lipoxin A4

Cat.No: T37305

Synonym: 6(S)-Lipoxin A4

9(Z),11(E)-Conjugated Linoleic Acid (sodium salt)

Cat.No: T35854

8(E),10(E),12(Z)-Octadecatrienoic Acid

Cat.No: T36887

Cat. No.	Product Name	Target	Signaling Pathways
T13669	(E)-Cinnamamide trans-Cinnamamide,肉桂酰胺	Others	Others
	(E)-Cinnamamide (trans-Cinnamamide) 是 Cinnamamide 的活性较低的异构体，Cinnamamide 是一种有效的非致命化学驱虫剂，适用于减少鸟类害虫的损害。
T4740	Elaidic acid 反油酸,trans-Oleic Acid	Endogenous Metabolite	Metabolism
	Elaidic acid (trans-Oleic Acid) 是在氢化植物油中发现的主要反式脂肪，能够被用作药物溶剂。在与花生四烯酸孵育的人类血小板中，反油酸抑制 HHT 和 HETE 的形成，同时诱导前列腺素和血栓素的合成。
T40424	9-cis-Vitamin A palmitate 9-cis-Vitamin A palmitate,9-cis-Retinyl palmitate
	9-cis-Vitamin A palmitate (9-cis-Retinyl palmitate) is a 9-cis isomer resulting from the interaction of vitamin A palmitate in corn flakes. It exhibits a biological activity of 26% compared to all-trans-vitamin A palmitate, which is known to be the most biologically active form of vitamin A.
T75679	13-cis-Vitamin A palmitate
	13-cis-Vitamin A palmitate（13-cis-Retinyl palmitate）是一种在玉米片中发现的维生素A棕榈酸酯的13-顺式异构体。其生物活性相当于全反式维生素A棕榈酸酯（维生素A具生物活性形式）的75%。
T37911	cis-Resveratrol 顺式白藜芦醇,(Z)-Resveratrol
	Resveratrol is a potent phenolic antioxidant found in grapes, red wine, and various berries that also has antiproliferative and anti-inflammatory activity. cis-Resveratrol is the double bond isomer of trans-resveratrol, the more often studied and naturally abundant of the two resveratrol isomers. cis-Resveratrol exhibits antioxidant activity in the &#181M range similar to that observed with trans-resveratrol. It blocks production of reactive oxygen species (ROS) by inhibition of NAD(P)H oxidase ...

天然产物

(E)-Cinnamamide

Cat.No: T13669

Synonym: trans-Cinnamamide,肉桂酰胺

Target: Others

Cat.No: T4740

Synonym: 反油酸,trans-Oleic Acid

Target: Endogenous Metabolite

9-cis-Vitamin A palmitate

Cat.No: T40424

Synonym: 9-cis-Vitamin A palmitate,9-cis-Retinyl palmitate

13-cis-Vitamin A palmitate

Cat.No: T75679

cis-Resveratrol

Cat.No: T37911

Synonym: 顺式白藜芦醇,(Z)-Resveratrol

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