permeation

Salcaprozate sodium (SNAC) 是口服吸收促进剂，有作为口服形式的肝素和胰岛素递送剂的潜力。它可提高非共价大分子络合引起的亲脂性，从而增加小肠上皮细胞的被动跨细胞渗透。

​Menthyl acetate 是一种可有效增强 5-氨基乙酰丙酸 (ALA) 皮肤渗透的 L-薄荷醇衍生物。​

Otaplimastat HCl是一种基质金属蛋白酶（MMP）抑制剂，可竞争性地阻断 NMDA 受体介导的兴奋性毒性，并表现出抗氧化活性。在缺氧-缺糖处理的内皮细胞中，Otaplimastat HCl 通过恢复在缺血状态下受抑的金属蛋白酶组织抑制因子（TIMP）水平，从而抑制 MMP 的活性而非其蛋白表达，进而减少血管通透性。Otaplimastat 为一种研究脑缺血性损伤与神经保护机制的重要工具，在神经药理学研究中具有潜在应用价值。

TH-237A is a novel neuroprotective agent exhibiting favorable permeation across the blood-brain barrier.

Butyl carbitol acetate enables deep permeation into the textile, with its low vapor pressure and boiling point.

Pal-KTTKS is a lipidated pentapeptide consisting of a fragment of the type I collagen C-terminal propeptide conjugated to palmitic acid .1 It increases collagen production in human corneal and dermal fibroblasts when used at concentrations of 0.002, 0.004, and 0.008 wt%.2 Following topical administration, pal-KTTKS (50 μg/cm2) is found in the stratum corneum, epidermis, and dermis of isolated hairless mouse skin.1 It can self-assemble into flat tapes and extended fibrillar structures.3 Pal-KTTKS has been detected in anti-wrinkle creams.4 |1. Choi, Y.L., Park, E.J., Kim, E., et al. Dermal stability and in vitro skin permeation of collagen pentapeptides (KTTKS and palmitoyl-KTTKS). Biomol. Ther. (Seoul) 22(4), 321-327 (2014).|2. Jones, R.R., Castelletto, V., Connon, C.J., et al. Collagen stimulating effect of peptide amphiphile C16-KTTKS on human fibroblasts. Mol. Pharm. 10(3), 1063-1069 (2013).|3. Castelletto, V., Hamley, I.W., Whitehouse, C., et al. Self-assembly of palmitoyl lipopeptides used in skin care products. Langmuir 29(29), 9149-9155 (2013).|4. Chirita, R.-I., Chaimbbault, P., Archambault, J.-C., et al. Development of a LC-MS/MS method to monitor palmitoyl peptides content in anti-wrinkle cosmetics. Anal. Chim. Acta 641(1-2), 95-100 (2009).

Cognac oil, predominantly derived from wine lees, exhibits distinctive fatty acid compositions, characterized by high proportions of Palmitic acid (59.26%), Linoleic acid (11.92%), Myristic acid (8.97%), and Oleic acid (8.3%) among other fatty acids. Notably, the application of Cognac oil enhances the permeability of Rhodamine 6G (R6G) across various membranes, resulting in a generalized increase in permeation.

Sephadex G 50 is a gel filtration medium commonly utilized in gel permeation chromatography for effective fractionation of glycopeptide mixtures.

AChE/BChE/BACE-1-IN-2 (Compound 4o) 表现出显著的抗氧化潜力和对PAS-AChE 的强大的结合能力。AChE/BChE/BACE-1-IN-2 是口服有效的AChE、BACE-1和BChE 抑制剂，对 hAChE、hBACE-1 和hBChE 的IC50分别为 0.069、0.097 和0.127 μM。AChE/BChE/BACE-1-IN-2 显示出对潜在的 Aβ 聚集物的分解能力和针对 Aβ 诱导的应激的神经保护作用。

Substance P (2-11)为P物质（SP）片段肽，具有对豚鼠回肠产生收缩活性的特性。同时，Substance P (2-11)能够抑制3H SP在BBMEC单分子层中的渗透。

HR1是一种乳突蛋白酶，可增加人红细胞膜渗透性，并能诱导细菌细胞质膜和肥大细胞质膜透化。

Cross-linked dextran G 200 是一种亲水型凝胶，以分子尺寸排阻为基础，用于大分子分离。该凝胶通过凝胶渗透机制工作，其交联结构形成特定孔径的三维网络，根据分子流体力学体积实现分离。它在凝胶过滤色谱中调节渗透溶质分配系数和维持渗透平衡，用于纯化和分析蛋白质、核酸等生物大分子。此外，Cross-linked dextran G 200 可作为凝胶过滤填料，具有粒径范围为40-120 μm，适用于分离球型蛋白范围为5k-600k Da。

Nortracheloside 是存在于 Trachelospermi caulis 和 Carissa edulis 的五种木脂素之一，其中前者广泛用于退热与镇痛。研究发现 Nortracheloside 可减少过敏原通透性并增强肠屏障功能，对食物过敏及炎症性肠病具有潜在的免疫调节作用。

Butyl carbitol acetate (Standard) is the standard substance of Butyl carbitol acetate, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Butyl carbitol acetate enables deep permeation into the textile, with its low vapor pressure and boiling point.

Hirsuteine 是提取自钩藤属植物中的吲哚生物碱。它可阻断离子渗透通过烟碱受体通道复合物，非竞争性地拮抗烟碱介导的多巴胺释放。

Taxol C 可以减少与 P-糖蛋白转运蛋白的相互作用，从而增加紫杉烷类向大脑的渗透。