fas receptor

Rimiducid 是一种可渗透脂质的他克莫司类似物，是一种二聚剂，通过交联 FKBP 结构域起作用。它将 Caspase 9 自杀开关二聚化并迅速诱导细胞凋亡。

TCPOBOP 是一种组成型雄烷受体激动剂，可诱导强大的肝细胞增殖和肝肿大。它通过改变 Bcl-2 蛋白来减少 Fas 诱导的小鼠肝损伤。

22(S)-hydroxy Cholesterol is a synthetic oxysterol and a modulator of the liver X receptor (LXR). [1] t prevents monocyte chemoattractant protein 1 (MCP-1) expression induced by the LXR agonist GW 3965 in primary hepatocytes and downregulates mRNA expression of the LXR target genes CD36, ACSL1, and SCD-1 in human myotubes. It decreases triacylglycerol and diacylglycerol synthesis from labeled palmitate and acetate, respectively, in human myoblasts by 50% when used at a concentration of 10 uM. 22(S)-hydroxy Cholesterol also reduces fatty acid synthase (FAS) reporter activity through an LXR response element in the promoter region in COS-1 cells transfected with RXRα and LXRα and decreases the expression of MCP-1 and CCR2 in a mouse model of chronic ethanol consumption.[1] [2] Dietary supplementation of 22(S)-hydroxy cholesterol (30 mg kg per day) leads to less body weight gain and lower liver triacylglycerol levels in rats when fed either a regular chow or high-fat diet as well as prevents an increase in plasma triacylglycerol levels resulting from a high-fat diet.[3]

Pseudoprotodioscin 是一种呋喃葡糖苷，抑制SREBP1 2和microRNA 33a b 水平，降低胆固醇和甘油三酯合成相关的基因表达。

Apoptotic agent-1 (Compound 8a) 诱导 Fas 受体和 Cyto C 基因的过表达，它是一种对癌细胞具有高抗增殖活性和低细胞毒性作用的凋亡剂。

LXR antagonist 2 (compound 10rr) 是一种有效的 LXR (肝 X 受体) 反向激动剂，能够作用于 LXRβ (IC50: 0.36 μM) 和 LXRα (IC50: 2.25 μM)。 LXR antagonist 2 是一种脂肪生成抑制剂，能够下调 LXR 靶基因 SREBP-1c、ACC、FAS 和 SCD-1。LXR antagonist 2 对 Triton WR-1339 诱导的高脂血症小鼠表现出降脂活性。

Met-12 是一种小肽抑制剂，作用于Fas受体，可抑制由Fas受体介导的光感受器细胞凋亡 (apoptosis)，并减少Caspase的激活。Met-12 可应用于光感受器保护剂的研究。