claudin1

Expression system: in vitro E. coli expression system
Length: 1-211, Full Length
Activity: Not Tested

Expression system: HEK293 Cells
Length: 1-211, Full Length
Activity: Not Tested

Claudin-18.2 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in E. coli expression system with N-6xHis and C-Avi tag. The predicted molecular weight is 13 KDa and the accession number is P56856-2.

Expression system: HEK293 Cells
Length: 1-261, Full Length of Isoform A2
Activity: ELISA

Expression system: HEK293 Cells
Length: 1-261, Full Length of Isoform A2
Activity: ELISA

Claudin-18.2 Protein-VLP, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 27.72 kDa and the accession number is NP_001002026.1.

Expression system: in vitro E. coli expression system
Length: 1-207, Full Length
Activity: Not Tested

Expression system: HEK293 Cells
Length: 1-261, Full Length of Isoform A2
Activity: BLI、ELISA

Claudin-18 Protein, Human, Recombinant (CLDN18.1) is expressed in HEK293 mammalian cells. The predicted molecular weight is 27.86 kDa and the accession number is P56856-1.

Claudin-18.2 Protein, Human, Recombinant (Insect, His) is expressed in Baculovirus Insect Cells. The accession number is P56856-2.

Claudin-18.1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-8xHis tag. The predicted molecular weight is 18 KDa and the accession number is P56856.

Claudin-18 (CLDN18) is a protein that in humans is encoded by the CLDN18 gene. It belongs to the group of claudins. CLDN18 belongs to the large claudin family of proteins, which form tight junction strands in epithelial cells. CLDN18 plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. CLDN18 has two isoform A1 and isoform A2. Human CLDN18.2 is highly expressed in a signifcant proportion of gastric and pancreatic adenocarcinomas，while normal tissue expression is limited to the epithelium of the stomach. The restricted expression makes it a potential drug target for the treatment of gastric and pancreatic adenocarcinoma, as evidenced by eforts to target CLDN18.2 via naked antibody and CAR-T modalities. IMAB362 (Claudiximab) is a monoclonal antibody against isoform 2 of Claudin-18. It is under investigation for the treatment of gastrointestinal adenocarcinomas and pancreatic tumors. IMAB362 was developed by Ganymed Pharmaceuticals AG.

Expression system: HEK293 Cells
Length: 1-264, Full Length of Isoform A2.1
Activity: ELISA

Claudin-11, also known as CLDN11, belongs to the group of claudins. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands function as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions.Claudin-11 is a tight junction associated protein and is a major component of central nervous system (CNS) myelin that is necessary for normal CNS function. Human blood-testis barrier disruption is related to a dysfunction of CLDN11 gene. It plays an important role in regulating proliferation and migration of oligodendrocytes.

Claudin-18.2 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-8xHis tag. The predicted molecular weight is 18 KDa and the accession number is P56856-2.