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19

抑制剂 & 化合物

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天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T21445	Naphazoline AK-Con,Naphcon-a,Clear Eyes,All Clear,萘甲唑林	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Naphazoline (Naphcon-a) 是一种具有显着 α 肾上腺素能活性的拟交感神经化合物。萘甲唑啉可用作血管收缩剂，当应用于粘膜时可快速减少肿胀。
T6469	Dichlorphenamide Diclofenamide,双氯非那胺,二氯苯二磺胺,Daranide,Antidrasi	Carbonic Anhydrase	Metabolism
	Dichlorphenamide (Diclofenamide) 是一种碳酸酐酶抑制剂。
T31738	Eyeseryl Ac-beta-ala-his-ser-his-oh
	Eyeseryl, also known as Acetyl Tetrapeptide-5, humectant or hydroscopic moisturizer which helps reduce eye puffiness, improve skin elasticity as well as overall smoothness.
T1223	Ceftriaxone sodium hydrate Ceftriaxone Sodium Trihydrate,头孢曲松钠,Ceftriaxone disodium hemiheptahydrate,头孢曲松钠水合物,Ceftriaxone sodium	Others; Antibacterial; Antibiotic	Microbiology/Virology; Others
	Ceftriaxone sodium hydrate 是一种头孢菌素类抗生素，对革兰氏阳性和革兰氏阴性菌均有活性。它具有抗炎和抗氧化作用。
T21371	Apraclonidine hydrochloride Iopidine,ALO 2145,Apraclonidina,P-aminoclonidine,4-Aminoclonidine,Apraclonidine HCl,Apraclonidinum	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Apraclonidine hydrochloride (ALO 2145) 是一种 α2-肾上腺素能激动剂和弱的 α-1 肾上腺素能受体激动剂。 Apaclonidine hydrochloride 可降低人眼的眼内压，可用于青光眼治疗的研究。
T15718	Latanoprost acid	GPR	Endocrinology/Hormones; GPCR/G Protein
	Latanoprost acid 是前列腺素受体的选择性激动剂，通过抑制 c-fos/NFATc1 通路抑制 RANKL 诱导的破骨细胞生成和功能。拉坦前列素酸可用于降低眼内压力的研究。
T25483	H-0106 Dihydrochloride H 0106 2HCl,H0106 2HCl,H0106 Dihydrochloride
	H-0106 Dihydrochloride is an inhibitor of ROCK that acts by applying strong intraocular pressure (IOP)-lowering effects into the eyes of monkeys.
T25482	H-0104 Dihydrochloride H0104 Dihydrochloride,H0104 2HCl,H 0104 Dihydrochloride,H 0104 2HCl,H-0104 2HCl
	H-0104 Dihydrochloride is an inhibitor of ROCK that acts by applying potent intraocular pressure (IOP)-lowering effects into the eyes of monkeys.
T60350	Apraclonidine
	Apraclonidine (ALO 2145) 是一种选择性α2和弱 α1 受体激动剂，可有效降低人眼的眼内压。Apraclonidine 也是一种局部滴眼液。
T10357	AR-13324 analog mesylate	Others	Others
	AR-13324 analog mesylate is an inhibitor of Rho-kinase and a norepinephrine transporter and reduces intraocular pressure in normotensive monkey eyes.
T10182	6-Hydroxybenzbromarone	Others	Others
	6-Hydroxybenzbromarone is the major metabolite of Benzbromarone. 6-Hydroxybenzbromarone is a protein Eyes Absent 3 (EYA3) inhibitor (IC50: 21.5 μM). It is an angiogenic agent, has strong inhibitory effects on cell migration, tubulogenesis, and angiogenic
T70763	KR-67607
	KR-67607, also known as NTX-101 is novel selective 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) inhibitor. KR-67607 decreased 4-hydroxynonenal expression and increased antioxidant and mucus secretion in BAC-treated rat eyes. KR-67607 showed its protective effects against ischemia-reperfusion-induced eye injury. KR-67607 effectively reduced cortisol levels in mouse eyes and maintained the trabecular meshwork (TM) structure in the presence of transient ischemic stress. Furthermore, KR-67607 rever...
T38194	Prostaglandin E3 PGE3
	Prostaglandin E3 (PGE3) is formed via the cyclooxygenase (COX) metabolism of eicosapentaenoic acid. [1] In human ocular tissue, it comprises 2.4% of the COX products formed. [1] When applied to the eyes of a rabbit, a 1 &#181g dose of PGE3 decreases intraocular pressure from 21 mmHg to about 17 mmHg.[2]
T37613	Ibuprofen Carboxylic Acid
	Ibuprofen carboxylic acid is a major metabolite of ibuprofen . It prevents fructose-, cyanate-, and prednisolone-induced inactivation of catalase and fructose- and cyanate-induced inactivation of fumarase when used at a concentration of 2 mM and penetrates into the lens of isolated bovine eyes. Ibuprofen carboxylic acid has been found in bank filtrate and surface water, as well as influent and effluent wastewater, and is considered a micropollutant.
T69623	Tridemorph
	Tridemorph is a sterol biosynthetic inhibitor. It is a fungicide used to control Erysiphe graminis. It was developed by BASF in the 1960s who use the trade name Calixin. The World Health Organization has categorized it as a Class II moderately hazardous" pesticide because it is believed harmful if swallowed and can cause irritation to skin and eyes."
T38219	11-cis Retinal
	11-cis Retinal is a chromophore that binds to opsin in the mammalian visual system as an inverse agonist forming the inactive conformation of rhodopsin. When 11-cis retinal absorbs a photon of light, it isomerizes to form all-trans retinal beginning the phototransduction cycle, which is the basis for mammalian vision. A G121L mutation in opsin allows 11-cis retinal to bind as a partial agonist and activate rhodopsin in the absence of light. In a moth model of carotenoid deficiency-induced low vi...
T38196	Prostaglandin F2α isopropyl ester Prostaglandin F2α isopropyl ester
	PGF2α isopropyl ester is an ester prodrug of PGF2α with enhanced lipid solubility. Due to better membrane penetration, PGF2α isopropyl ester is more suitable than PGF2α or PGF2α tromethamine salt for topical application in studies on intraocular pressure. The ester functionality is readily hydrolyzed in vivo to release the active compound PGF2α. When administered topically to the eyes of cynomolgus monkeys, a 5 μg dose reduces intraocular pressure by 68% after the fourth day of treatment.
T71119	Netarsudil free base
	Netarsudil, also known as AR-11324, is a Rho-associated protein kinase inhibitor. Netarsudil is potential useful for treating glaucoma and/or reducing intraocular pressure. Netarsudil Increases Outflow Facility in Human Eyes Through Multiple Mechanisms. Netarsudil inhibited kinases ROCK1 and ROCK2 with a Ki of 1 nM each, disrupted actin stress fibers and focal adhesions in TM cells with IC50s of 79 and 16 nM, respectively, and blocked the profibrotic effects of TGF-β2 in HTM cells. Netarsudi...
T31194	Dalapon Basfapon B,Dowpon M,Dawpon-Rae
	Dalapon is a selective herbicide used to control perennial grasses. The major use of dalapon is on food crops including sugarcane and sugar beets. Its use is no longer authorized in France. The National Institute for Occupational Safety and Health in the

化合物

Cat.No: T21445

Synonym: AK-Con,Naphcon-a,Clear Eyes,All Clear,萘甲唑林

Target: Adrenergic Receptor

Dichlorphenamide

Cat.No: T6469

Synonym: Diclofenamide,双氯非那胺,二氯苯二磺胺,Daranide,Antidrasi

Target: Carbonic Anhydrase

Cat.No: T31738

Synonym: Ac-beta-ala-his-ser-his-oh

Ceftriaxone sodium hydrate

Cat.No: T1223

Synonym: Ceftriaxone Sodium Trihydrate,头孢曲松钠,Ceftriaxone disodium hemiheptahydrate,头孢曲松钠水合物,Ceftriaxone sodium

Target: Others, Antibacterial, Antibiotic

Apraclonidine hydrochloride

Cat.No: T21371

Synonym: Iopidine,ALO 2145,Apraclonidina,P-aminoclonidine,4-Aminoclonidine,Apraclonidine HCl,Apraclonidinum

Target: Adrenergic Receptor

Latanoprost acid

Cat.No: T15718

Target: GPR

H-0106 Dihydrochloride

Cat.No: T25483

Synonym: H 0106 2HCl,H0106 2HCl,H0106 Dihydrochloride

H-0104 Dihydrochloride

Cat.No: T25482

Synonym: H0104 Dihydrochloride,H0104 2HCl,H 0104 Dihydrochloride,H 0104 2HCl,H-0104 2HCl

Cat.No: T60350

AR-13324 analog mesylate

Cat.No: T10357

Target: Others

6-Hydroxybenzbromarone

Cat.No: T10182

Target: Others

Cat.No: T70763

Prostaglandin E3

Cat.No: T38194

Synonym: PGE3

Ibuprofen Carboxylic Acid

Cat.No: T37613

Cat.No: T69623

Cat.No: T38219

Prostaglandin F2α isopropyl ester

Cat.No: T38196

Synonym: Prostaglandin F2α isopropyl ester

Netarsudil free base

Cat.No: T71119

Cat.No: T31194

Synonym: Basfapon B,Dowpon M,Dawpon-Rae

Cat. No.	Product Name	Target	Signaling Pathways
T3746	Dimethyl phthalate 邻苯二甲酸二甲酯,Solvanom,Avolin,Fermine,避蚊酯	Others	Others
	Dimethyl phthalate (Fermine) 是一种邻苯二甲酸酯 (PAEs)，是一种已知的内分泌干扰物，也是一种普遍存在的污染物。它常作为增塑剂，赋予硬质聚氯乙烯 (PVC) 树脂以柔韧性。

天然产物

Dimethyl phthalate

Cat.No: T3746

Synonym: 邻苯二甲酸二甲酯,Solvanom,Avolin,Fermine,避蚊酯

Target: Others

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