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Search Results for " ca1 "

Targets Recommended: PKA PDE

22

抑制剂 & 化合物

5

天然产物

12

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T1418	Bucladesine sodium dbcAMP,Dibutyryl-cAMP sodium salt,布拉地新钠盐,Dibutyryl-cAMP,DC2797,Sodium dibutyryl cAMP,Bucladesine,Bucladesine sodium salt	PKA; PDE	Metabolism; Tyrosine Kinase/Adaptors
	Bucladesine sodium (DC2797) 是一种 cAMP 类似物，具有细胞渗透性。Bucladesine sodium 也是一种 cAMP 依赖性的蛋白激酶 (PKA) 激活剂，一种磷酸二酯 (PDE) 抑制剂。Bucladesine sodium 具有抗炎活性。
T22967	MEDICA16 MEDICA 16	GPR; Others; ATP Citrate Lyase	Endocrinology/Hormones; GPCR/G Protein; Metabolism; Others
	MEDICA16 是 GPR40 的特异性激动剂以及 GPR120 的部分激动剂。 MEDICA16 是一种 ATP-柠檬酸裂解酶抑制剂，可显着降低腓肠肌中的细胞内 TG 含量，同时增加胰岛素敏感性。
T10601	BRCA1-IN-2	Others	Others
	BRCA1-IN-2 是一种可穿过细胞膜的 BRCA1 蛋白-蛋白相互作用（PPI）抑制剂，具有抗肿瘤活性，通过破坏 BRCA1 (BRCT)2 与蛋白质的相互作用来发挥作用。
T5315	TCA1 TCA-1,TCA 1	Antibacterial; Antibiotic	Microbiology/Virology
	TCA1 (TCA 1) 是一种小分子，具有抗耐药性和持续性结核病的活性。
T72195	KCa1.1 channel activator-2
	KCa1.1 channel activator-2 (化合物 3F) 是一种槲皮素衍生物，是选择性的血管 KCa1.1 channel 刺激剂。KCa1.1 channel activator-2 具有强效的肌肉松弛活性。
T40296	MCA17-1 MCA17-1
	MCA17-1 exhibits superior bioactivity compared to the positive control, obeticholic acid (OCA), in the treatment of liver fibrosis.
T72194	KCa1.1 channel activator-1
	KCa1.1 channel activator-1 (化合物 1E) 是一种槲皮素衍生物，是选择性的血管 KCa1.1 channel 刺激剂。KCa1.1 channel activator-1 也显示 CaV1.2 channel 通道阻断活性。KCa1.1 channel activator-1 表现出较弱的肌肉松弛活性。
T10600	BRCA1-IN-1	Others	Others
	BRCA1-IN-1 is a novel small-molecule-like inhibitor of BRCA1 (IC50: 0.53 μM; Ki: 0.71 μM).
T38192	Unifiram	Others	Others
	Unifiram 是一种认知增强剂。 Unifiram 诱导大鼠海马 CA1 区场兴奋性突触后电位 (fEPSP) 幅度的持久增加 (EC50= 27 nM) 并增加大鼠大脑皮层中乙酰胆碱 (ACh) 的释放。
TP1945L1	Pep2m, myristoylated acetate Pep2m, myristoylated acetate(1423381-07-0 free base)	PKC	Chromatin/Epigenetic; Cytoskeletal Signaling
	Pep2m, myristoylated acetate(1423381-07-0 free base) 是一种细胞可渗透的肉豆蔻酰化形式的 pep2m。 GluA2（AMPA 受体）亚基的 C 末端与 N-乙基马来酰亚胺敏感融合蛋白 (NSF)（一种调节 AMPA 受体功能的蛋白质）之间相互作用的肽抑制剂。降低 CA1 神经元中的突触后电流、培养的海马神经元中 AMPA 介导的电流和 AMPA 受体表面表达。
TP1895L1	KYL acetate(676657-00-4 free base)	Ephrin Receptor	Tyrosine Kinase/Adaptors
	KYL acetate(676657-00-4 free base) 是EphA4受体酪氨酸激酶抑制剂（Kd = 0.8 μM）；抑制 EphA4-EphrinA5 相互作用 (IC50 = 6.34 μM)。防止 AβO 诱导的突触损伤、树突棘丢失并防止海马 CA3-CA1 传输中 LTP 的阻断。在细胞培养基中表现出较长的半衰期（在 PC3 和 C2C12 培养基中分别为 8 和 12 小时）。它有神经保护作用。
T0782	Benzthiazide Aquatag,苄噻嗪,Lemazide,Dihydrex	Carbonic Anhydrase	Metabolism
	Benzthiazide (Lemazide) 是长效利尿剂及抗高血压剂。它也是碳酸酐酶 9 的抑制剂，他对 CA9，CA2 和 CA1 的 Ki 分别为 8.0，8.8 和 10 nM。它对肿瘤细胞增殖具有抑制作用。
T73099	Etbicyphat Trimethylopropane phosphate
	Etbicyphat (Trimethylopropane phosphate)作为一种GABA(A)受体竞争性拮抗剂展现出显著效果。通过诱发海马体CA1神经元的类似癫痫的活动并与GABA(A)-benzodiazepine受体结合，Etbicyphat的作用机制得到了阐述。
T37208	NAP-1
	NAP-1 is a compound with anesthetic activity.1 It increases paired-pulse inhibition in the CA1 region of rat hippocampal brain slices when used at a concentration of 100 μM. NAP-1 also induces loss of righting reflex in tadpoles (EC50 = 0.53 μM).References NAP-1 is a compound with anesthetic activity.1 It increases paired-pulse inhibition in the CA1 region of rat hippocampal brain slices when used at a concentration of 100 μM. NAP-1 also induces loss of righting reflex in tadpoles (EC50 = 0.53 μ...
T24919	UBP714 UBP 714,UBP-714
	UBP714 is a derivative of the NMDA receptor negative allosteric modulator UBP608. It also enhanced NMDAR mediated field EPSPs in the CA1 region of the hippocampus. UBP714 is a novel template for the development of potent and subunit selective NMDAR potent
T76590	(d(CH2)51,Tyr(Me)2,Thr4,Orn8,des-Gly-NH29)-Vasotocin
	(d(CH2)51,Tyr(Me)2,Thr4,Orn8,des-Gly-NH29)-Vasotocin，是一种催产素受体拮抗剂，可消除 CA1 锥体神经元中催产素增强的抑制性突触后电流。
T28653	S-8510 free base SB 737552,SB-737552,S8510,SB737552,S-8510,S 8510
	S-8510 is a GABA-A receptor inverse agonist. S-8510 selectively potentiated pentylenetetrazol-induced convulsion without affecting minimal electroconvulsive shock- or strychnine-induced convulsion in ddY mice. S-8510 ameliorated memory impairment induced
TP1895	KYL peptide KYL
	KYL peptide is an EphA4 receptor tyrosine kinase inhibitor (Kd = 0.8 μM); inhibits EphA4-EphrinA5 interactions (IC50 = 6.34 μM). Prevents AβO induced synaptic damage, dendritic spine loss and prevents the blocking of LTP in hippocampal CA3-CA1 transmissions. Exhibits a long half life in cell culture media (8 and 12 hours in PC3 and C2C12 media respectively). Neuroprotective.
TP1945	Pep2m, myristoylated
	Cell-permeable, myristoylated form of pep2m. Peptide inhibitor of the interaction between the C-terminus of the GluA2 (AMPA receptor) subunit and N-ethylmaleimide-sensitive fusion protein (NSF), a protein that regulates AMPA receptor function. Reduces pos
T70063	GYKI 52466 HCl
	GYKI 52466 is an allosteric AMPA receptor antagonist. It selectively inhibits AMPA-induced inward currents (IC50 = 7.5 µM) over NMDA- or GABA-induced inward currents in primary rat hippocampal neurons at 50 µM but also inhibits kainate-induced inward currents in the same cells (IC50 = 11 µM).2 GYKI 52466 (10 µM) reduces the amplitude of spontaneous excitatory postsynaptic currents (EPSCs) in the same cells. It increases the latency to seizure onset and reduces mortality in a rat model of general...
T64672	Colivelin TFA
	Colivelin (sequence SALLRSIPAPAGASRLLLLTGEIDLP) is composed of activity-dependent neurotrophic factor (ADNF) C-terminally fused to AGA-(C8R)HNG17, a potent HN derivative. It works as a neuroprotective peptide and activator of STAT3. Colivelin-induced neuroprotection has been confirmed to occur via two neuroprotective pathways: one mediated by Ca2+/calmodulin-dependent protein kinase IV, triggered by ADNF, and one mediated by signal transducer and activator of transcription 3, triggered by HN. Co...
T37388	Afizagabar
	Afizagabar (S44819) is a first-in-class, competitive, and selective antagonist at the GABA-binding site of the α5-GABAAR, with an IC50 of 585 nM for α5β2γ2 and a Ki of 66 nM for α5β3γ2. Afizagabar enhances hippocampal synaptic plasticity and exhibits pro-cognitive efficacy[1]. Afizagabar (S44819) is a competitive α5-GABAAR antagonist (Kb=221 nM). Afizagabar selectively inhibits extrasynaptic α5-GABAARs of mouse CA1 pyramidal neurons[1]. Afizagabar (1 and 3 mg/kg; i.p.) significantly diminishes t...

化合物

Bucladesine sodium

Cat.No: T1418

Synonym: dbcAMP,Dibutyryl-cAMP sodium salt,布拉地新钠盐,Dibutyryl-cAMP,DC2797,Sodium dibutyryl cAMP,Bucladesine,Bucladesine sodium salt

Target: PKA, PDE

Cat.No: T22967

Synonym: MEDICA 16

Target: GPR, Others, ATP Citrate Lyase

Cat.No: T10601

Target: Others

Cat.No: T5315

Synonym: TCA-1,TCA 1

Target: Antibacterial, Antibiotic

KCa1.1 channel activator-2

Cat.No: T72195

Cat.No: T40296

Synonym: MCA17-1

KCa1.1 channel activator-1

Cat.No: T72194

Cat.No: T10600

Target: Others

Cat.No: T38192

Target: Others

Pep2m, myristoylated acetate

Cat.No: TP1945L1

Synonym: Pep2m, myristoylated acetate(1423381-07-0 free base)

Target: PKC

KYL acetate(676657-00-4 free base)

Cat.No: TP1895L1

Target: Ephrin Receptor

Cat.No: T0782

Synonym: Aquatag,苄噻嗪,Lemazide,Dihydrex

Target: Carbonic Anhydrase

Cat.No: T73099

Synonym: Trimethylopropane phosphate

Cat.No: T37208

Cat.No: T24919

Synonym: UBP 714,UBP-714

(d(CH2)51,Tyr(Me)2,Thr4,Orn8,des-Gly-NH29)-Vasotocin

Cat.No: T76590

S-8510 free base

Cat.No: T28653

Synonym: SB 737552,SB-737552,S8510,SB737552,S-8510,S 8510

Cat.No: TP1895

Synonym: KYL

Pep2m, myristoylated

Cat.No: TP1945

Cat.No: T70063

Cat.No: T64672

Cat.No: T37388

Cat. No.	Product Name	Target	Signaling Pathways
T9143	D-Isoleucine (2R,3R)-2-Amino-3-methylpentanoic acid,D-异亮氨酸,(R)-Isoleucine	Others	Others
	D-Isoleucine ((2R,3R)-2-Amino-3-methylpentanoic acid) 是一种异亮氨酸立体异构体，是 Asc-1 反转运蛋白的选择性激活剂。它能够释放内源性 D-丝氨酸，提高海马 CA1-CA3 的长期增效作用。
TN1601	Effusol 灯心草菲酚,厄弗酚	Caspase	Apoptosis; Proteases/Proteasome
	Effusol 是一种从 Juncus effuses 中分离到的酚类物质，对 DPPH 自由基(IC50:79 μM) 及 ABTS 自由基(IC50:2.73 μM)具有较强的清除活性。它能挽救皮质酮减弱的 CA1 LTP，保护海马功能对抗应激诱导的认知能力下降。
T6S2115	Ginkgolide J BN 52024,7-beta-Hydroxyginkgolide A,银杏内酯 J,银杏内酯J	PDE	Metabolism
	Ginkgolide J (BN 52024) 是一种银杏叶中非黄酮部分的主要成分(IC50:12-54 µM)，具有神经保护和抗神经元凋亡功能。
T14011	2-Arachidonoylglycerol	Cannabinoid Receptor; Endogenous Metabolite	GPCR/G Protein; Metabolism
	2-Arachidonoylglycerol 属于人内源性代谢物，是中枢神经系统中的一种内源性大麻素配体。
T36448	(E)-Ajoene
	(E)-Ajoene is a disulfide that has been found inA. sativumand has diverse biological activities.1,2,3,4It is active against Gram-positive and Gram-negative bacteria (MICs = 10-250 and 150->500 μg/ml, respectively) and fungi (MICs = 15-50 μg/ml).1(E)-Ajoene inhibits proliferation of a variety of cancer cells, including MDA-MB-231 breast, HeLa cervical, and WHCO1 esophageal cancer cells (IC50s = 18.6, 61, and 39.2 μM, respectively).2It also inhibits human glutathione reductase andT. cruzitrypanoth...

天然产物

Cat.No: T9143

Synonym: (2R,3R)-2-Amino-3-methylpentanoic acid,D-异亮氨酸,(R)-Isoleucine

Target: Others

Cat.No: TN1601

Synonym: 灯心草菲酚,厄弗酚

Target: Caspase

Cat.No: T6S2115

Synonym: BN 52024,7-beta-Hydroxyginkgolide A,银杏内酯 J,银杏内酯J

Target: PDE

2-Arachidonoylglycerol

Cat.No: T14011

Target: Cannabinoid Receptor, Endogenous Metabolite

Cat.No: T36448

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-03258	Carbonic Anhydrase 1 Protein, Rat, Recombinant (His & SUMO) Cyanamide hydratase CA1,CA-I,...	Rat	E. coli
	Reversible hydration of carbon dioxide. Carbonic Anhydrase 1 Protein, Rat, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 44.2 kDa and the accession number is B0BNN3.
TMPJ-00731	Carbonic Anhydrase 1 Protein, Human, Recombinant (His) Carbonic Anhydrase B,Carbonate Dehydratase...	Human	E. coli
	Carbonic Anhydrase 1 (CA1) is a cytosolic enzyme, belonging to the alpha-carbonic anhydrase family. It is highly expressed in erythrocytes and acts as an early marker for erythroid differentiation. Carbonic anhydrase 1 plays a improtant role in many biological processes such as calcification, cellular respiration, bone resorption, acid-base balance. It is activated by imidazole, histamine, L-adrenaline, L- and D-histidine, and L- and D-phenylalanine. At the same time, It is inhibited by sulfonam...
TMPH-02936	FUCA1 Protein, Mouse, Recombinant (His & SUMO)	Mouse	E. coli
	Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins. FUCA1 Protein, Mouse, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 66.6 kDa and the accession number is Q99LJ1.
TMPH-01564	ICA1 Protein, Human, Recombinant (His)	Human	P. pastoris (Yeast)
	May play a role in neurotransmitter secretion.
TMPK-01394	CA125/MUC16 Protein, Human, Recombinant (aa 12783-13467, His) CA125,MUC16,CA1...	Human	HEK293 Cells
	CA125/MUC16 Protein, Human, Recombinant (aa 12783-13467, His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 76.17 kDa and the accession number is Q8WXI7.
TMPK-01365	CA125/MUC16 Protein, Human, Recombinant (aa 12783-13467, His & AVI), Biotinylated CA-125,FLJ14303,CA1<...	Human	HEK293 Cells
	CA125/MUC16 Protein, Human, Recombinant (aa 12783-13467, His & AVI), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 77.98 kDa and the accession number is Q8WXI7.
TMPK-01366	CA125/MUC16 Protein, Human, Recombinant (aa 12660-12923, His & AVI), Biotinylated CA125,CA-125,MUC1	Human	HEK293 Cells
	CA125/MUC16 Protein, Human, Recombinant (aa 12660-12923, His & AVI), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 31.3 kDa and the accession number is Q8WXI7.
TMPJ-01432	CA125/MUC16 Protein, Human, Recombinant (hFc & AVI), Biotinylated mucin 16, cell surface associated,CA-1...	Human	HEK293 Cells
	MUC16, also known as the CA125 antigen, is a mucin protein that may be found in type I transmembrane or secreted forms that are used monitor the progress of epithelial ovarian cancer therapy. MUC16 is over-expressed by tumor cells including ovarian and mesothelial cancers. The transmembrane form can adhere to mesothelin in the peritoneum, facilitating metastasis of ovarian cancer to the peritoneal cavity. MUC16 also binds galectin-1 on immune cells and enhances its expression on tumor cells. MUC...
TMPY-06614	CA125/MUC16 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	CA125/MUC16 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 73.27 kDa and the accession number is Q8WXI7-1.
TMPK-01359	CA125/MUC16 Protein, Human, Recombinant (His & Avi) MUC16,CA-125,CA1	Human	HEK293 Cells
	CA125/MUC16 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 31.3 kDa and the accession number is Q8WXI7.
TMPY-03282	FUCA1 Protein, Human, Recombinant (His) fucosidase, alpha-L- 1, tissue,fucosidase, α-L-	Human	HEK293 Cells
	FUCA1 is a lysosomal enzyme involved in the degradation of fucose-containing glycoproteins and glycolipids. Mutations in FUCA1 gene are associated with fucosidosis (FUCA1D), which is an autosomal recessive lysosomal storage disease. Different phenotypes include clinical features such as neurologic deterioration, growth retardation, visceromegaly, and seizures in a severe early form; coarse facial features, angiokeratoma corporis diffusum, spasticity and delayed psychomotor development in a longe...
TMPY-01734	CA13 Protein, Human, Recombinant (His) carbonic anhydrase XIII,FLJ37995,CAXIII,MG...	Human	E. coli
	The carbonic anhydrases (or carbonate dehydratases) are classified as metalloenzyme for its zinc ion prosthetic group and form a family of enzymes that catalyze the rapid interconversion of carbon dioxide and water to bicarbonate and protons, a reversible reaction that takes part in maintaining acid-base balance in blood and other tissues. The carbonic anhydrasekl (CA) family consists of at least 11 enzymatically active members and a few inactive homologous proteins. The CAXIII is a member of th...

重组蛋白

Carbonic Anhydrase 1 Protein, Rat, Recombinant (His & SUMO)

Cat.No: TMPH-03258

Species: Rat

Expression System: E. coli

Carbonic Anhydrase 1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00731

Species: Human

Expression System: E. coli

FUCA1 Protein, Mouse, Recombinant (His & SUMO)

Cat.No: TMPH-02936

Species: Mouse

Expression System: E. coli

ICA1 Protein, Human, Recombinant (His)

Cat.No: TMPH-01564

Species: Human

Expression System: P. pastoris (Yeast)

CA125/MUC16 Protein, Human, Recombinant (aa 12783-13467, His)

Cat.No: TMPK-01394

Species: Human

Expression System: HEK293 Cells

CA125/MUC16 Protein, Human, Recombinant (aa 12783-13467, His & AVI), Biotinylated

Cat.No: TMPK-01365

Species: Human

Expression System: HEK293 Cells

CA125/MUC16 Protein, Human, Recombinant (aa 12660-12923, His & AVI), Biotinylated

Cat.No: TMPK-01366

Species: Human

Expression System: HEK293 Cells

CA125/MUC16 Protein, Human, Recombinant (hFc & AVI), Biotinylated

Cat.No: TMPJ-01432

Species: Human

Expression System: HEK293 Cells

CA125/MUC16 Protein, Human, Recombinant (His)

Cat.No: TMPY-06614

Species: Human

Expression System: HEK293 Cells

CA125/MUC16 Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-01359

Species: Human

Expression System: HEK293 Cells

FUCA1 Protein, Human, Recombinant (His)

Cat.No: TMPY-03282

Species: Human

Expression System: HEK293 Cells

CA13 Protein, Human, Recombinant (His)

Cat.No: TMPY-01734

Species: Human

Expression System: E. coli

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