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Search Results for " ad 5 "

Targets Recommended: Others

10

抑制剂 & 化合物

11

重组蛋白

3

同位素标记化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T29633	AD 5 AD-5,AD5	Others	Others
	AD 5 is a bioactive chemical.
T1180	Blonanserin 布南色林,AD-5423	Dopamine Receptor; Sigma receptor; 5-HT Receptor; Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Blonanserin (AD-5423) 是一种有效的5-HT2A 和多巴胺 D2 受体拮抗剂，Ki 为 0.812 和 0.142 nM，是一种非典型的抗精神病试剂。
T84317	AVN 322 free base	5-HT Receptor	GPCR/G Protein; Neuroscience
	AVN 322 free base 是一种可口服且具有选择性和高效性的 5-HT6R 拮抗剂，可用于研究阿尔茨海默病（AD）和精神分裂症等神经病理系统疾病。
T79684	5-HT6R antagonist 1	5-HT Receptor	GPCR/G Protein; Neuroscience
	5-HT6R antagonist 1（Compound 8）是一款具有突出代谢稳定性的5-HT6R拮抗剂（Ki: 5 nM），能有效抑制血小板聚集，并可逆转由MK-801引起的大鼠记忆障碍。此化合物在阿尔茨海默病（AD）的研究中有潜在应用价值。
T27269	Ensaculin HCl KA 672,KA672,Ensaculin,Anseculin Hydrochloride,KA-672 HCl	Others	Others
	Ensaculin is a NMDA antagonist and a 5HT1A agonist potentially for the treatment of Alzheimer's disease (AD). Ensaculin showed memory-enhancing effects in paradigms of passive and conditioned avoidance in both normal and artificially amnesic rodents. It e
T72893	AChE/MAO-IN-2	Others	Others
	Dual AChE-MAO B-IN-5 是一种茚满酮衍生物，是一种有效的双重 AChE/MAO-B 抑制剂，对 AChE、MAO-B 和 MAO-A 的IC50值分别为 0.0224、0.0412 和 0.1116 μM。Dual AChE-MAO B-IN-5 具有抗氧化活性，防止 β-淀粉样斑块聚集。Dual AChE-MAO B-IN-5 可用于阿尔茨海默病 (AD) 研究。
T79533	PDE5-IN-10	Others	Others
	PDE5-IN-10 (compound 4b)，一有效PDE5抑制剂，IC50值为20 nM。该化合物体外微粒体稳定性增强（t1/2= 44.6 分钟），在长期增强恢复方面效果显著，适用于阿尔茨海默病（AD）研究。
T63216	γ-Secretase modulator 11	Others	Others
	5-{8-[（3，4'-二氟[1，1'-联苯]-4-基）甲氧基]-2-甲基咪唑并[1，2-a]吡啶-3-基}-N-甲基吡啶-2-甲酰胺（1o）具有较高的体外效力和脑暴露效果，能够使脑Aβ42水平的明显降低，且对细胞色素p450酶无抑制作用。此外，化合物1o 在AD 模型小鼠中表现出优异的抗认知缺陷作用。
T74461	Chalcones A-N-5	Others	Others
	ChalconesA-N-5, 一种三羟基查耳酮衍生物化合物，浓度低于100 µM (IC50> 1 mM) 时无细胞毒性，能显着促进细胞增殖。此外，ChalconesA-N-5 能促进受损脑组织中神经元的生长，抑制RSL或erastin诱导的铁死亡，并降低Aβ1-42蛋白聚集引发的脂质过氧化水平。因此，ChalconesA-N-5 作为分子骨架的候选物，对于开发用以研究AD的体内试验先导化合物具有重要潜力。
T38002	LEO 39652	Others	Others
	LEO 39652 is a dual-soft PDE4 inhibitor with IC50s of 1.2 nM, 1.2 nM, 3.0 nM and 3.8 nM for PDE4A, PDE4B, PDE4C and PDE4D, respectively. LEO 39652 also inhibits TNF-α with an IC50 value of 6.0 nM. LEO 39652 is used for topical research of Atopic dermatitis (AD) [1]. LEO 39652 shows unbound in vitro potency when measured as LPS induced TNF-α release in human peripheral blood mononuclear cells (PBMC), incubated in serum free medium. LEO 39652 shows a relatively high binding to human serum albumin...

化合物

Cat.No: T29633

Synonym: AD-5,AD5

Target: Others

Cat.No: T1180

Synonym: 布南色林,AD-5423

Target: Dopamine Receptor, Sigma receptor, 5-HT Receptor, Adrenergic Receptor

AVN 322 free base

Cat.No: T84317

Target: 5-HT Receptor

5-HT6R antagonist 1

Cat.No: T79684

Target: 5-HT Receptor

Cat.No: T27269

Synonym: KA 672,KA672,Ensaculin,Anseculin Hydrochloride,KA-672 HCl

Target: Others

Cat.No: T72893

Target: Others

Cat.No: T79533

Target: Others

γ-Secretase modulator 11

Cat.No: T63216

Target: Others

Chalcones A-N-5

Cat.No: T74461

Target: Others

Cat.No: T38002

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-05528	Apolipoprotein E/APOE3 Protein, Human, Recombinant (His & Trx), Biotinylated APO-E,LDLCQ5,LPG,ApoE4,AD2,apolipoprotein ...	Human	E. coli
	Apolipoprotein E/APOE3 Protein, Human, Recombinant (His & Trx), Biotinylated is expressed in E. coli expression system with His and Trx tag. The predicted molecular weight is 51.3 kDa and the accession number is P02649.
TMPY-05297	Apolipoprotein E/APOE3 Protein, Human, Recombinant (His & Trx) LPG,apolipoprotein E,ApoE4,APO-E,LDLCQ5,AD...	Human	E. coli
	Apolipoprotein E/APOE3 Protein, Human, Recombinant (His & Trx) is expressed in E. coli expression system with His and Trx tag. The predicted molecular weight is 51.3 kDa and the accession number is P02649.
TMPY-05308	CD45 Protein, Human, Recombinant (aa 1-529, His) GP180,B220,L-CA,protein tyrosine phosphatase, receptor type,...	Human	HEK293 Cells
	CD45 Protein, Human, Recombinant (aa 1-529, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 57.4 kDa and the accession number is P08575-5.
TMPY-01953	CALML5 Protein, Human, Recombinant (His & GST) calmodulin like 5,CLSP	Human	E. coli
	Calmodulin-like protein 5, also known as Calmodulin-like skin protein, CALML5 and CLSP, is a protein which contains fourEF-hand domains. CALML5 / CLSP is particularly abundant in the epidermis where its expression is directly related to keratinocyte differentiation.The expression is very low in lung. CALML5 / CLSP binds calcium. It may be involved in terminal differentiation of keratinocytes. Coxsackievirus and adenovirus receptor (CAR) is a member of the immunoglobulin (Ig) superfamily a...
TMPY-05387	SLAMF7 Protein, Human, Recombinant (hFc) SLAM family member 7,19A,SLAM7,CS1,CD319,CRACC	Human	HEK293 Cells
	SLAMF7 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 49.1 kDa and the accession number is Q9NQ25-5.
TMPY-04318	GRIK2 Protein, Human, Recombinant (hFc) GLUR6,EAA4,MRT6,GLR6,glutamate receptor, ionotropic, kainate...	Human	HEK293 Cells
	GRIK2 (Glutamate Ionotropic Receptor Kainate Type Subunit 2, also known as GluR6) is a Protein Coding gene. The GRIK2 (one of the kainate receptors) gene resides in a genetic linkage region (6q21) associated with bipolar disorder (BPD). The gene coding for GRIK2 has been suggested as a candidate gene for autism based on its localization in the autism-specific region on chromosome 6q21 and the involvement of receptor protein in cognitive functions like learning and memory. GRIK2 belongs to the gl...
TMPY-05547	SLAMF7 Protein, Human, Recombinant (hFc), Biotinylated CS1,SLAM7,CD319,SLAM family member 7,CRACC,19A	Human	HEK293 Cells
	SLAMF7 Protein, Human, Recombinant (hFc), Biotinylated is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 49.1 kDa and the accession number is Q9NQ25-5.
TMPY-05498	SR-BI/SCARB1 Protein, Human, Recombinant (hFc) HDLQTL6,SR-BI,SRB1,CD36L1,CLA-1,CLA1,scavenger receptor clas...	Human	HEK293 Cells
	SR-BI/SCARB1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 73.4 kDa and the accession number is Q8WTV0-5.
TMPJ-00854	ETS1 Protein, Human, Recombinant (His) V-ets Erythroblastosis Virus E26 Oncogene Homolog 1 (Avian),...	Human	E. coli
	ETS1 Protein (ETS1) is a nuclear protein that belongs to the ETS family. Members of this family recognize the core consensus DNA sequence GGAA/T in target genes. Proteins function either as transcriptional activators or repressors of numerous genes. They are involved in stem cell development, cell senescence and death, and tumorigenesis. ETS1 is a transcription factor, containing one ETS DNA-binding domain and one PNT (pointed) domain. it has been shown to interact with TTRAP, UBE2I and Death As...
TMPK-01357	SIRP alpha V5 Protein, Human, Recombinant (His & Avi) MFR,PTPNS1,P84,BIT,MYD-1,MYD1,SHPS-1,SIRPA,SIRP α,SIRP α V	Human	HEK293 Cells
	Signal regulatory protein α (SIRPα) is a regulatory membrane glycoprotein from SIRP family expressed mainly by myeloid cells and also by stem cells or neurons.SIRPα acts as inhibitory receptor and interacts with a broadly expressed transmembrane protein CD47 also called the "don´t eat me" signal.
TMPK-01363	SIRP alpha V5 Protein, Human, Recombinant (His & Avi), Biotinylated SIRP alpha,MFR,PTPNS1,SIRP α V5,P84,SHPS-1,BIT,CD17...	Human	HEK293 Cells
	Signal regulatory protein α (SIRPα) is a regulatory membrane glycoprotein from SIRP family expressed mainly by myeloid cells and also by stem cells or neurons.SIRPα acts as inhibitory receptor and interacts with a broadly expressed transmembrane protein CD47 also called the "don´t eat me" signal.Cancer cells highly expressed CD47 that activate SIRP α and inhibit macrophage-mediated destruction. SIRP alpha V5 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian c...

重组蛋白

Apolipoprotein E/APOE3 Protein, Human, Recombinant (His & Trx), Biotinylated

Cat.No: TMPY-05528

Species: Human

Expression System: E. coli

Apolipoprotein E/APOE3 Protein, Human, Recombinant (His & Trx)

Cat.No: TMPY-05297

Species: Human

Expression System: E. coli

CD45 Protein, Human, Recombinant (aa 1-529, His)

Cat.No: TMPY-05308

Species: Human

Expression System: HEK293 Cells

CALML5 Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-01953

Species: Human

Expression System: E. coli

SLAMF7 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-05387

Species: Human

Expression System: HEK293 Cells

GRIK2 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-04318

Species: Human

Expression System: HEK293 Cells

SLAMF7 Protein, Human, Recombinant (hFc), Biotinylated

Cat.No: TMPY-05547

Species: Human

Expression System: HEK293 Cells

SR-BI/SCARB1 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-05498

Species: Human

Expression System: HEK293 Cells

ETS1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00854

Species: Human

Expression System: E. coli

SIRP alpha V5 Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-01357

Species: Human

Expression System: HEK293 Cells

SIRP alpha V5 Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-01363

Species: Human

Expression System: HEK293 Cells

Cat. No.	Product Name	Target	Signaling Pathways
T10558	Blonanserin D5 AD-5423 D5	Others	Others
	Blonanserin D5 is a deuterium-labeled Blonanserin. Blonanserin (AD-5423) is a dopamine D2/5-HT2 receptor antagonist with an atypical antipsychotic effect.
T10559	Blonanserin D8 AD-5423 D8	Others	Others
	Blonanserin D8 is a deuterium-labeled Blonanserin. Blonanserin (AD-5423) is a dopamine D2/5-HT2 receptor antagonist with an atypical antipsychotic effect.
T37847	Zonisamide-13C2,15N Zonisamide-13C2,15N
	Zonisamide-13C2,15N is intended for use as an internal standard for the quantification of zonisamide by GC- or LC-MS. Zonisamide is an antiepileptic agent.1 It selectively inhibits the repeated firing of sodium channels (IC50 = 2 μg/ml) in mouse embryo spinal cord neurons and inhibits spontaneous channel firing when used at concentrations greater than 10 μg/ml.2 In rat cerebral cortex neurons, zonisamide (1-1,000 μM) inhibits T-type calcium channels with a maximum reduction of 60% of the calcium...

同位素标记化合物

Cat.No: T10558

Synonym: AD-5423 D5

Target: Others

Cat.No: T10559

Synonym: AD-5423 D8

Target: Others

Zonisamide-13C2,15N

Cat.No: T37847

Synonym: Zonisamide-13C2,15N

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