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12

抑制剂 & 化合物

17

重组蛋白

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Cat. No. Product Name Target Signaling Pathways
T29633 AD 5

AD-5,AD5

AD 5 is a bioactive chemical.
T1180 Blonanserin

布南色林,AD-5423

Dopamine Receptor; Sigma receptor; 5-HT Receptor; Adrenergic Receptor GPCR/G Protein; Neuroscience
Blonanserin (AD-5423) 是一种有效的5-HT2A 和多巴胺 D2 受体拮抗剂,Ki 为 0.812 和 0.142 nM,是一种非典型的抗精神病试剂。
T10558 Blonanserin D5

AD-5423 D5

Others Others
Blonanserin D5 is a deuterium-labeled Blonanserin. Blonanserin (AD-5423) is a dopamine D2/5-HT2 receptor antagonist with an atypical antipsychotic effect.
T10559 Blonanserin D8

AD-5423 D8

Others Others
Blonanserin D8 is a deuterium-labeled Blonanserin. Blonanserin (AD-5423) is a dopamine D2/5-HT2 receptor antagonist with an atypical antipsychotic effect.
T79684 5-HT6R antagonist 1

5-HT Receptor GPCR/G Protein; Neuroscience
5-HT6R antagonist 1(Compound 8)是一款具有突出代谢稳定性的5-HT6R拮抗剂(Ki: 5 nM),能有效抑制血小板聚集,并可逆转由MK-801引起的大鼠记忆障碍。此化合物在阿尔茨海默病(AD)的研究中有潜在应用价值。
T27269 Ensaculin HCl

KA 672,KA672,Ensaculin,Anseculin Hydrochloride,KA-672 HCl

Ensaculin is a NMDA antagonist and a 5HT1A agonist potentially for the treatment of Alzheimer's disease (AD). Ensaculin showed memory-enhancing effects in paradigms of passive and conditioned avoidance in both normal and artificially amnesic rodents. It e
T72893 AChE/MAO-IN-2

Dual AChE-MAO B-IN-5 是一种茚满酮衍生物,是一种有效的双重 AChE/MAO-B 抑制剂,对 AChE、MAO-B 和 MAO-A 的IC50值分别为 0.0224、0.0412 和 0.1116 μM。Dual AChE-MAO B-IN-5 具有抗氧化活性,防止 β-淀粉样斑块聚集。Dual AChE-MAO B-IN-5 可用于阿尔茨海默病 (AD) 研究。
T79533 PDE5-IN-10

PDE5-IN-10 (compound 4b),一有效PDE5抑制剂,IC50值为20 nM。该化合物体外微粒体稳定性增强(t1/2= 44.6 分钟),在长期增强恢复方面效果显著,适用于阿尔茨海默病(AD)研究。
T63216 γ-Secretase modulator 11

5-{8-[(3,4'-二氟[1,1'-联苯]-4-基)甲氧基]-2-甲基咪唑并[1,2-a]吡啶-3-基}-N-甲基吡啶-2-甲酰胺(1o)具有较高的体外效力和脑暴露效果,能够使脑Aβ42水平的明显降低,且对细胞色素p450酶无抑制作用。此外,化合物1o 在AD 模型小鼠中表现出优异的抗认知缺陷作用。
T74461 Chalcones A-N-5

ChalconesA-N-5, 一种三羟基查耳酮衍生物化合物,浓度低于100 µM (IC50> 1 mM) 时无细胞毒性,能显着促进细胞增殖。此外,ChalconesA-N-5 能促进受损脑组织中神经元的生长,抑制RSL或erastin诱导的铁死亡,并降低Aβ1-42蛋白聚集引发的脂质过氧化水平。因此,ChalconesA-N-5 作为分子骨架的候选物,对于开发用以研究AD的体内试验先导化合物具有重要潜力。
T38002 LEO 39652

LEO 39652 is a dual-soft PDE4 inhibitor with IC50s of 1.2 nM, 1.2 nM, 3.0 nM and 3.8 nM for PDE4A, PDE4B, PDE4C and PDE4D, respectively. LEO 39652 also inhibits TNF-α with an IC50 value of 6.0 nM. LEO 39652 is used for topical research of Atopic dermatitis (AD) [1]. LEO 39652 shows unbound in vitro potency when measured as LPS induced TNF-α release in human peripheral blood mononuclear cells (PBMC), incubated in serum free medium. LEO 39652 shows a relatively high binding to human serum albumin...
T37847 Zonisamide-13C2,15N

Zonisamide-13C2,15N

Zonisamide-13C2,15N is intended for use as an internal standard for the quantification of zonisamide by GC- or LC-MS. Zonisamide is an antiepileptic agent.1 It selectively inhibits the repeated firing of sodium channels (IC50 = 2 μg/ml) in mouse embryo spinal cord neurons and inhibits spontaneous channel firing when used at concentrations greater than 10 μg/ml.2 In rat cerebral cortex neurons, zonisamide (1-1,000 μM) inhibits T-type calcium channels with a maximum reduction of 60% of the calcium...

化合物

AD 5
Cat.No: T29633
Synonym: AD-5,AD5
Target:
Blonanserin
Cat.No: T1180
Synonym: 布南色林,AD-5423
Target: Dopamine Receptor, Sigma receptor, 5-HT Receptor, Adrenergic Receptor
Blonanserin D5
Cat.No: T10558
Synonym: AD-5423 D5
Target: Others
Blonanserin D8
Cat.No: T10559
Synonym: AD-5423 D8
Target: Others
5-HT6R antagonist 1
Cat.No: T79684
Synonym:
Target: 5-HT Receptor
Ensaculin HCl
Cat.No: T27269
Synonym: KA 672,KA672,Ensaculin,Anseculin Hydrochloride,KA-672 HCl
Target:
AChE/MAO-IN-2
Cat.No: T72893
Synonym:
Target:
PDE5-IN-10
Cat.No: T79533
Synonym:
Target:
γ-Secretase modulator 11
Cat.No: T63216
Synonym:
Target:
Chalcones A-N-5
Cat.No: T74461
Synonym:
Target:
LEO 39652
Cat.No: T38002
Synonym:
Target:
Zonisamide-13C2,15N
Cat.No: T37847
Synonym: Zonisamide-13C2,15N
Target:
Cat. No. Product Name Species Expression System
TMPY-05297 Apolipoprotein E/APOE3 Protein, Human, Recombinant (His & Trx)

LPG,apolipoprotein E,ApoE4,APO-E,LDLCQ5,AD...

Human E. coli
Apolipoprotein E (ApoE) is a 34.2 kDa glycosylated protein with 299 amino acid residues. There are three isoforms in human (apoE2, apoE3, and apoE4) due to different amino acid residues at positions 112 and 158. ApoE is synthesized predominantly in the liver, but also by cells in the spleen, brain, lung, kidney, ovary, adrenal, and muscle tissues. Hepatic parenchyma cells are the main apoE producing cells in mammalian body, probably accounting for two thirds to three fourths of the plasma apoE ....
TMPY-05528 Apolipoprotein E/APOE3 Protein, Human, Recombinant (His & Trx), Biotinylated

APO-E,LDLCQ5,LPG,ApoE4,AD2,apolipoprotein ...

Human E. coli
Apolipoprotein E (ApoE) is a 34.2 kDa glycosylated protein with 299 amino acid residues. There are three isoforms in human (apoE2, apoE3, and apoE4) due to different amino acid residues at positions 112 and 158. ApoE is synthesized predominantly in the liver, but also by cells in the spleen, brain, lung, kidney, ovary, adrenal, and muscle tissues. Hepatic parenchyma cells are the main apoE producing cells in mammalian body, probably accounting for two thirds to three fourths of the plasma apoE ....
TMPY-05308 CD45 Protein, Human, Recombinant (aa 1-529, His)

GP180,B220,L-CA,protein tyrosine phosphatase, receptor type,...

Human HEK293
The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins d...
TMPY-00413 TGF beta 2 Protein, Mouse, Recombinant (His)

Tgfb-2,Tgf-beta2,TGF-beta 2,Tgf-β2,TGFB2,TGF-β2,TGF β2,转化生长因...

Mouse HEK293
TGF beta 2 (Transforming growth factor beta 2), an extracellular glycosylated protein, which belongs to the TGF-beta family. TGF-beta regulates key mechanisms of tumor development, namely immunosuppression, metastasis, angiogenesis, and proliferation. TGF beta 2 suppression is a promising therapeutic approach for malignant tumor therapy. The signaling pathway of TGF beta 2/Smad plays an important role in the pathological process in posterior capsule opacification (PCO) after cataract surgery. Si...
TMPY-04577 TGF beta 2 Protein, Rhesus, Recombinant (His)

TGF-beta 2,transforming growth factor beta 2,transforming gr...

Rhesus HEK293
TGF beta 2 (Transforming growth factor beta 2), an extracellular glycosylated protein, which belongs to the TGF-beta family. TGF-beta regulates key mechanisms of tumor development, namely immunosuppression, metastasis, angiogenesis, and proliferation. TGF beta 2 suppression is a promising therapeutic approach for malignant tumor therapy. The signaling pathway of TGF beta 2/Smad plays an important role in the pathological process in posterior capsule opacification (PCO) after cataract surgery. Si...
TMPY-05314 TGF beta 2 Protein, Mouse, Recombinant (His), Biotinylated

transforming growth factor β2,TGF β2,转化生长因子,Tgfb-2,TGF-β2,BB...

Mouse HEK293
TGF beta 2 (Transforming growth factor beta 2), an extracellular glycosylated protein, which belongs to the TGF-beta family. TGF-beta regulates key mechanisms of tumor development, namely immunosuppression, metastasis, angiogenesis, and proliferation. TGF beta 2 suppression is a promising therapeutic approach for malignant tumor therapy. The signaling pathway of TGF beta 2/Smad plays an important role in the pathological process in posterior capsule opacification (PCO) after cataract surgery. Si...
TMPY-00231 TGF beta 2 Protein, Canine, Recombinant (His)

transforming growth factor β2,转化生长因子,TGF-beta 2,TGF-β2,TGFB2...

Canine HEK293
TGF beta 2 (Transforming growth factor beta 2), an extracellular glycosylated protein, which belongs to the TGF-beta family. TGF-beta regulates key mechanisms of tumor development, namely immunosuppression, metastasis, angiogenesis, and proliferation. TGF beta 2 suppression is a promising therapeutic approach for malignant tumor therapy. The signaling pathway of TGF beta 2/Smad plays an important role in the pathological process in posterior capsule opacification (PCO) after cataract surgery. Si...
TMPY-01953 CALML5 Protein, Human, Recombinant (His & GST)

calmodulin like 5,CLSP

Human E. coli
Calmodulin-like protein 5, also known as Calmodulin-like skin protein, CALML5 and CLSP, is a protein which contains fourEF-hand domains. CALML5 / CLSP is particularly abundant in the epidermis where its expression is directly related to keratinocyte differentiation.The expression is very low in lung. CALML5 / CLSP binds calcium. It may be involved in terminal differentiation of keratinocytes. Coxsackievirus and adenovirus receptor (CAR) is a member of the immunoglobulin (Ig) superfamily a...
TMPY-01732 LRPAP1 Protein, Mouse, Recombinant (His)

C77774,AU042172,RAP,AI790446,low density lipoprotein recepto...

Mouse HEK293
Receptor-associated protein (RAP) is a molecular chaperone for low-density lipoprotein receptor-related protein (LRP), which plays a key role in cholesterol metabolism. The lipoprotein receptor-related protein (LRP) is an endocytic receptor for several ligands, such as alpha2-macroglobulin (alpha2 M) and apolipoprotein E. LRP is involved in the clearance of lipids from the bloodstream and is expressed in the atherosclerotic plaque. The LRP-associated protein (LRPAP in humans, RAP in mice) acts a...
TMPY-01233 LRPAP1 Protein, Human, Recombinant (His)

HBP44,MYP23,low density lipoprotein receptor-related protein...

Human HEK293
Receptor-associated protein (RAP) is a molecular chaperone for low-density lipoprotein receptor-related protein (LRP), which plays a key role in cholesterol metabolism. The lipoprotein receptor-related protein (LRP) is an endocytic receptor for several ligands, such as alpha2-macroglobulin (alpha2 M) and apolipoprotein E. LRP is involved in the clearance of lipids from the bloodstream and is expressed in the atherosclerotic plaque. The LRP-associated protein (LRPAP in humans, RAP in mice) acts a...
TMPY-05387 SLAMF7 Protein, Human, Recombinant (hFc)

SLAM family member 7,19A,SLAM7,CS1,CD319,CRACC

Human HEK293
SLAM family member 7 (SLAMF7), also known as CRACC, CD319, CD2-like receptor-activating cytotoxic cells, and CS1, is a single-pass type I membrane protein and a member of the CD2 family of cell surface receptors. SLAMF7 is expressed in NK cells, activated B-cells, NK-cell line but not in promyelocytic, B-cell lines, or T-cell lines. Although the cytoplasmic domain of CS1 contains immunoreceptor tyrosine-based switch motifs (ITSM), which enables to recruit signaling lymphocyte activation molecule...
TMPY-04318 GRIK2 Protein, Human, Recombinant (hFc)

GLUR6,EAA4,MRT6,GLR6,glutamate receptor, ionotropic, kainate...

Human HEK293
GRIK2 (Glutamate Ionotropic Receptor Kainate Type Subunit 2, also known as GluR6) is a Protein Coding gene. The GRIK2 (one of the kainate receptors) gene resides in a genetic linkage region (6q21) associated with bipolar disorder (BPD). The gene coding for GRIK2 has been suggested as a candidate gene for autism based on its localization in the autism-specific region on chromosome 6q21 and the involvement of receptor protein in cognitive functions like learning and memory. GRIK2 belongs to the gl...
TMPJ-00854 ETS1 Protein, Human, Recombinant (His)

V-ets Erythroblastosis Virus E26 Oncogene Homolog 1 (Avian),...

Human E. coli
ETS1 Protein (ETS1) is a nuclear protein that belongs to the ETS family. Members of this family recognize the core consensus DNA sequence GGAA/T in target genes. Proteins function either as transcriptional activators or repressors of numerous genes. They are involved in stem cell development, cell senescence and death, and tumorigenesis. ETS1 is a transcription factor, containing one ETS DNA-binding domain and one PNT (pointed) domain. it has been shown to interact with TTRAP, UBE2I and Death As...
TMPY-05547 SLAMF7 Protein, Human, Recombinant (hFc), Biotinylated

CS1,SLAM7,CD319,SLAM family member 7,CRACC,19A

Human HEK293
SLAM family member 7 (SLAMF7), also known as CRACC, CD319, CD2-like receptor-activating cytotoxic cells, and CS1, is a single-pass type I membrane protein and a member of the CD2 family of cell surface receptors. SLAMF7 is expressed in NK cells, activated B-cells, NK-cell line but not in promyelocytic, B-cell lines, or T-cell lines. Although the cytoplasmic domain of CS1 contains immunoreceptor tyrosine-based switch motifs (ITSM), which enables to recruit signaling lymphocyte activation molecule...
TMPY-05498 SR-BI/SCARB1 Protein, Human, Recombinant (hFc)

HDLQTL6,SR-BI,SRB1,CD36L1,CLA-1,CLA1,scavenger receptor clas...

Human HEK293
Scavenger receptor class B, member 1 (SCARB1), also known as CD36L1, is a member of the scavenger receptor family. SCARB1 is expressed primarily in liver and non placental steroidogenic tissues, and predominantly localized to cholesterol and sphingomyelin-enriched domains within the plasma membrane. SCARB1 is proposed as a receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells, and is involved in a wide variety of physilogica...
TMPK-01357 SIRP alpha V5 Protein, Human, Recombinant (His & Avi)

MFR,PTPNS1,P84,BIT,MYD-1,MYD1,SHPS-1,SIRPA,SIRP α,SIRP α V

Human HEK293
Signal regulatory protein α (SIRPα) is a regulatory membrane glycoprotein from SIRP family expressed mainly by myeloid cells and also by stem cells or neurons.SIRPα acts as inhibitory receptor and interacts with a broadly expressed transmembrane protein CD47 also called the "don´t eat me" signal.
TMPK-01363 SIRP alpha V5 Protein, Human, Recombinant (His & Avi), Biotinylated

SIRP alpha,MFR,PTPNS1,SIRP α V5,P84,SHPS-1,BIT,CD17...

Human HEK293
Signal regulatory protein α (SIRPα) is a regulatory membrane glycoprotein from SIRP family expressed mainly by myeloid cells and also by stem cells or neurons.SIRPα acts as inhibitory receptor and interacts with a broadly expressed transmembrane protein CD47 also called the "don´t eat me" signal.Cancer cells highly expressed CD47 that activate SIRP α and inhibit macrophage-mediated destruction.

重组蛋白

Apolipoprotein E/APOE3 Protein, Human, Recombinant (His & Trx)
Cat.No: TMPY-05297
Species: Human
Expression System: E. coli
Apolipoprotein E/APOE3 Protein, Human, Recombinant (His & Trx), Biotinylated
Cat.No: TMPY-05528
Species: Human
Expression System: E. coli
CD45 Protein, Human, Recombinant (aa 1-529, His)
Cat.No: TMPY-05308
Species: Human
Expression System: HEK293
TGF beta 2 Protein, Mouse, Recombinant (His)
Cat.No: TMPY-00413
Species: Mouse
Expression System: HEK293
TGF beta 2 Protein, Rhesus, Recombinant (His)
Cat.No: TMPY-04577
Species: Rhesus
Expression System: HEK293
TGF beta 2 Protein, Mouse, Recombinant (His), Biotinylated
Cat.No: TMPY-05314
Species: Mouse
Expression System: HEK293
TGF beta 2 Protein, Canine, Recombinant (His)
Cat.No: TMPY-00231
Species: Canine
Expression System: HEK293
CALML5 Protein, Human, Recombinant (His & GST)
Cat.No: TMPY-01953
Species: Human
Expression System: E. coli
LRPAP1 Protein, Mouse, Recombinant (His)
Cat.No: TMPY-01732
Species: Mouse
Expression System: HEK293
LRPAP1 Protein, Human, Recombinant (His)
Cat.No: TMPY-01233
Species: Human
Expression System: HEK293
SLAMF7 Protein, Human, Recombinant (hFc)
Cat.No: TMPY-05387
Species: Human
Expression System: HEK293
GRIK2 Protein, Human, Recombinant (hFc)
Cat.No: TMPY-04318
Species: Human
Expression System: HEK293
ETS1 Protein, Human, Recombinant (His)
Cat.No: TMPJ-00854
Species: Human
Expression System: E. coli
SLAMF7 Protein, Human, Recombinant (hFc), Biotinylated
Cat.No: TMPY-05547
Species: Human
Expression System: HEK293
SR-BI/SCARB1 Protein, Human, Recombinant (hFc)
Cat.No: TMPY-05498
Species: Human
Expression System: HEK293
SIRP alpha V5 Protein, Human, Recombinant (His & Avi)
Cat.No: TMPK-01357
Species: Human
Expression System: HEK293
SIRP alpha V5 Protein, Human, Recombinant (His & Avi), Biotinylated
Cat.No: TMPK-01363
Species: Human
Expression System: HEK293
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