8hete

8(S)-HETE is a major lipoxygenase product in PMA-treated murine epidermis. It activates mouse keratinocyte protein kinase C with an IC50 of 100 μM. 8(S)-HETE also activates PPARα selectively at concentrations as low as 0.3 μM. Stereochemical assignment of the (S) enantiomer is based on comparison of chiral HPLC retention times to published results.

(±)8-HETE 在生命科学相关研究中具有广泛的应用。

8(R)-HETE is biosynthesized by lipoxygenation of arachidonic acid in marine invertebrates such as gorgonian corals and starfish. Stereochemical assignment of the (R) enantiomer is based on comparison of chiral HPLC retention times to published results.

(±)18-HETE(18-Hydroxyeicosatetraenoic acid)是18号碳上有羟基的花生四烯酸代谢物，由细胞色素P-450催化生成。