Delta-AITX-Avd1c Protein, Anemonia sulcata, Recombinant (His)

Binds specifically to voltage-gated sodium channels (Nav) (site 3), thereby delaying their inactivation. Has a strong effect on crustaceans and insects (DmNav1) and a weaker effect on mammals. This toxin is highly potent at mammalian Nav1.1/SCN1A (EC(50)=6.01 nM) and Nav1.2/SCN2A (EC(50)=7.88 nM). It has also great activity on Nav1.5/SCN5A (EC(50)=49.05 nM), Nav1.4/SCN4A (EC(50)=109.49 nM) and Nav1.6/SCN8A (EC(50)=about 180 nM) and is less potent on Nav1.3/SCN3A (EC(50)=759.22 nM) (when measured as the increase in the slow component).

规格	价格/CNY		数量
20 μg	￥ 2,570	20日内发货
100 μg	￥ 4,890	20日内发货
1 mg	￥ 17,500	20日内发货

规格

价格/CNY

货期

数量

20 μg

￥ 2,570

20日内发货

100 μg

￥ 4,890

20日内发货

1 mg

￥ 17,500

20日内发货

产品描述

种属	Anemonia sulcata
表达系统	P. pastoris (Yeast)
标签	N-6xHis
蛋白编号	P01528
别名	ATX II, Delta-AITX-Avd1c, Toxin II, Delta-actitoxin-Avd1c, Neurotoxin 2, ATX-II, Anemonia sulcata toxin 2, As2
氨基酸序列	GVPCLCDSDGPSVRGNTLSGIIWLAGCPSGWHNCKKHGPTIGWCCKQ
蛋白构建	1-47 aa
蛋白纯度	> 90% as determined by SDS-PAGE.
分子量	6.9 kDa (predicted)

缓冲液	Tris-based buffer, 50% glycerol
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.
研究背景	Binds specifically to voltage-gated sodium channels (Nav) (site 3), thereby delaying their inactivation. Has a strong effect on crustaceans and insects (DmNav1) and a weaker effect on mammals. This toxin is highly potent at mammalian Nav1.1/SCN1A (EC(50)=6.01 nM) and Nav1.2/SCN2A (EC(50)=7.88 nM). It has also great activity on Nav1.5/SCN5A (EC(50)=49.05 nM), Nav1.4/SCN4A (EC(50)=109.49 nM) and Nav1.6/SCN8A (EC(50)=about 180 nM) and is less potent on Nav1.3/SCN3A (EC(50)=759.22 nM) (when measured as the increase in the slow component).

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Delta-AITX-Avd1c Protein, Anemonia sulcata, Recombinant (His)

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