Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Mardepodect (PF-2545920) 是一种有效的、口服具有活性的、可透过血脑屏障的、选择性的 PDE10A 抑制剂,IC50=0.37 nM,比作用于其他 PDE 选择性高 1000 多倍。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 622 | 现货 | ||
2 mg | ¥ 913 | 现货 | ||
5 mg | ¥ 1,160 | 现货 | ||
10 mg | ¥ 2,180 | 现货 | ||
25 mg | ¥ 3,830 | 现货 | ||
50 mg | ¥ 5,490 | 现货 | ||
100 mg | ¥ 7,720 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 1,280 | 现货 |
产品描述 | Mardepodect (PF-2545920) is a phosphodiesterase inhibitor selective for the PDE10A subtype with an IC50 of 0.37 nM, >1000-fold selectivity over PDE. It is potentially useful for the treatment of schizophrenia. Phosphodiesterase 10A (PDE10A) is highly expressed in striatal medium spiny neurons of both the direct and indirect output pathways. Mardepodect can cross the blood-brain barrier. |
靶点活性 | PDE10A:0.37 nM |
体内活性 | Mardepodect is active in a range of antipsychotic models with the ED50 of 1 mg/kg, antagonizing apomorphine-induced climbing in mice, inhibiting conditioned avoidance responding in both rats and mice, and blocking N-methyl-D-aspartate antagonist-induced deficits in prepulse inhibition of acoustic startle response in rats, while improving baseline sensory gating in mice.Mardepodect induces a dose-dependent increase in striatal cGMP in mice. |
别名 | PF-2545920 |
分子量 | 392.45 |
分子式 | C25H20N4O |
CAS No. | 898562-94-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 45 mg/mL (114.66 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.5481 mL | 12.7405 mL | 25.481 mL | 63.7024 mL |
5 mM | 0.5096 mL | 2.5481 mL | 5.0962 mL | 12.7405 mL | |
10 mM | 0.2548 mL | 1.274 mL | 2.5481 mL | 6.3702 mL | |
20 mM | 0.1274 mL | 0.637 mL | 1.274 mL | 3.1851 mL | |
50 mM | 0.051 mL | 0.2548 mL | 0.5096 mL | 1.274 mL | |
100 mM | 0.0255 mL | 0.1274 mL | 0.2548 mL | 0.637 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Mardepodect 898562-94-2 Metabolism PDE PF-02545920 inhibit PF 2545920 PF-2545920 Inhibitor Phosphodiesterase (PDE) PF2545920 inhibitor