Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Encequidar mesylate (HM30181A mesylate) 是竞争性有效的 P-糖蛋白抑制剂。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 281 | 现货 | ||
5 mg | ¥ 663 | 现货 | ||
10 mg | ¥ 913 | 现货 | ||
25 mg | ¥ 1,690 | 现货 | ||
50 mg | ¥ 2,890 | 现货 | ||
100 mg | ¥ 4,330 | 现货 | ||
500 mg | ¥ 9,360 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 788 | 现货 |
产品描述 | Encequidar mesylate (HM30181A mesylate) is a competitive P-glycoprotein inhibitor. |
体外活性 | Treatment of 0.1 or 1 nM Encequidar lead to 20 and 42% inhibition of survival at the 100 nM and 1000 nM NSC 125973 treatment, respectively [2]. |
体内活性 | The plasma concentrations of Encequidar are higher for the simultaneous administration with the microcapsule than with the powder; providing significant differences from 1 to 2 h. The microcapsule has about a 1.7-fold faster Tmax and a 1.6-fold higher AUC value compared with the powder (2.5±0.6 vs. 4.3±0.9 h; 107.7±20.1 vs. 64.3±18.0 h ng/mL). The faster and overall improved absorption of Encequidar in microcapsule form might be due to the remarkable enhancement of the aqueous solubility and dissolution resulting from its crystalline conversion to the amorphous form and particle size reduction [1]. |
别名 | HM30181 mesylate, HM30181A mesylate |
分子量 | 784.83 |
分子式 | C39H40N6O10S |
CAS No. | 849675-87-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 25 mg/mL (31.85 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 1.2742 mL | 6.3708 mL | 12.7416 mL | 31.854 mL |
5 mM | 0.2548 mL | 1.2742 mL | 2.5483 mL | 6.3708 mL | |
10 mM | 0.1274 mL | 0.6371 mL | 1.2742 mL | 3.1854 mL | |
20 mM | 0.0637 mL | 0.3185 mL | 0.6371 mL | 1.5927 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Encequidar mesylate 849675-87-2 Membrane transporter/Ion channel Neuroscience P-gp HM30181A HM 30181 Mesylate HM30181 Mesylate HM 30181 HM30181 mesylate Encequidar Mesylate HM30181 MDR1 ABCB1 HM-30181 Mesylate inhibit CD243 P-glycoprotein Cluster of differentiation 243 HM-30181 Inhibitor HM30181A Mesylate Encequidar Pgp HM30181A mesylate Multidrug resistance protein 1 inhibitor