Powder: -20°C for 3 years | In solvent: -80°C for 1 year
AX-15836是一种选择性 ERK5抑制剂,IC50值为8 nM。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 497 | 现货 | ||
2 mg | ¥ 743 | 现货 | ||
5 mg | ¥ 1,230 | 现货 | ||
10 mg | ¥ 1,820 | 现货 | ||
25 mg | ¥ 3,150 | 现货 | ||
50 mg | ¥ 4,480 | 现货 | ||
100 mg | ¥ 6,280 | 现货 | ||
500 mg | ¥ 12,600 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 1,770 | 现货 |
产品描述 | AX-15836 is an inhibitor of ERK5 (IC50 : 8 nM). |
靶点活性 | ERK5:8 nM |
体外活性 | AX15836 was completely ineffective (EC50>10 μM) to suppress inflammatory cytokine response, suggesting that it was the BRD inhibition component of the compounds that mediated cytokine reduction. AX-15836 shows more than 1,000-fold selectivity for ERK5 over a panel of over 200 kinases and it also shows similar intracellular potency (4–9 nM) across all cells tested, including peripheral blood mononuclear cells (PBMCs), endothelial cells, and oncogenic cell lines. It also exhibits selectivity over BRD4 with a Kd of 3,600 nM. In HUVEC and HeLa cell types, samples treated with AX15836 shows very few genes to be differentially expressed. AX15836 could clearly inhibit the EGF-stimulated, phosphorylated form of ERK5 in HeLa cells[1]. |
分子量 | 648.78 |
分子式 | C32H40N8O5S |
CAS No. | 2035509-96-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (154.14 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 1.5414 mL | 7.7068 mL | 15.4135 mL | 38.5339 mL |
5 mM | 0.3083 mL | 1.5414 mL | 3.0827 mL | 7.7068 mL | |
10 mM | 0.1541 mL | 0.7707 mL | 1.5414 mL | 3.8534 mL | |
20 mM | 0.0771 mL | 0.3853 mL | 0.7707 mL | 1.9267 mL | |
50 mM | 0.0308 mL | 0.1541 mL | 0.3083 mL | 0.7707 mL | |
100 mM | 0.0154 mL | 0.0771 mL | 0.1541 mL | 0.3853 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
AX-15836 2035509-96-5 MAPK ERK Extracellular signal regulated kinases AX 15836 inhibit AX15836 Inhibitor inhibitor