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NEDD8

NEDD8 is a protein that in humans is encoded by the NEDD8 gene.(in saccharomyces cerevisiae this protein is known as Rub1) This ubiquitin-like (UBL) protein becomes covalently conjugated to a limited number of cellular proteins, in a process called NEDDylation similar to ubiquitination. Human NEDD8 shares 60% amino acid sequence identity to ubiquitin. The primary known substrates of NEDD8 modification are the cullin subunits of cullin-based E3 ubiquitin ligases, which are active only when NEDDylated. Their NEDDylation is critical for the recruitment of E2 to the ligase complex, thus facilitating ubiquitin conjugation. NEDD8 modification has therefore been implicated in cell cycle progression and cytoskeletal regulation.

Cat. No.	Product Name	CAS No.	Purity
T5374	NAcM-OPT 化合物NAcM-OPT	2089293-61-6	99.68%
T5374	NAcM-OPT 是口服活性、有效的 cullin neddylation 1 抑制剂，可以抑制 DCN1-UBE2M 相互作用。
T6332	Pevonedistat 化合物Pevonedistat	905579-51-3	99.2%
T6332	Pevonedistat (MLN4924) 是一种 NEDD8 活化酶 (NAE) 抑制剂 (IC50=4.7 nM)，具有有效性和选择性。Pevonedistat 可以用于骨髓增生异常综合症 (MDS)的治疗，也具有抗肿瘤活性。
T9140	NAcM-OPT HCl(2089293-61-6 free base) 化合物NAcM-OPT HCl	2416146-10-4	98.93%
T9140	NAcM-OPT HCl(2089293-61-6 free base) 是一种可口服的 cullin neddylation 1 (DCN1) 抑制剂，靶向 N-Acetyl-UBE2M（E2 结合酶，UBC12）与 DCN1 的相互作用，IC50 为 79 nM。
T13090	TAS4464 hydrochloride 化合物TAS4464 hydrochloride	1848959-11-4	98.18%
T13090	TAS4464 hydrochloride 是高效的、选择性的 NEDD8 活化酶 (NAE)抑制剂，其 IC50=0.955 nM。