succinate

ALK2-IN-4 succinate is a robust and effective inhibitor of ALK2.

Hydrocortisone sodium succinate is a glucocorticoid which is used to alleviate allergic reactions, particularly those of the skin and gums.

Lanraplenib succinate inhibits SYK activity in platelets via the glycoprotein VI (GPVI) receptor without prolonging bleeding time (BT) in monkeys or humans. Lanraplenib succinate is a highly selective and orally active SYK inhibitor (IC50=9.5 nM) in development for the treatment of inflammatory diseases.

PF-0463481 succinate is a potent and orally active dual antagonist of CCR2 CCR5 with comparable human and rodent CCR2 potency with IC50 of 20.8 nM.

Ribociclib succinate hydrate is a highly specific CDK4 6 inhibitor (IC50s: 10 nM and 39 nM, respectively). It also is over 1,000-fold less potent against the cyclin B CDK1 complex.

m-PEG-Succinimidyl Succinate (MW 5000) is a polyethylene glycol (PEG)-based linker featuring succinimidyl succinate functionality, primarily applied in the synthesis of proteolysis-targeting chimeras (PROTACs)[1].

Succinate dehydrogenase-IN-4 (Compound 4b) 是一种琥珀酸脱氢酶抑制剂，IC50为3.38 μM。它对Physalospora piricola 和Colletotrichum orbiculare 显示出抗真菌活性，EC50分别为16.33 μM和18.06 μM。

Succinate dehydrogenase-IN-5 (Compound M8) 是一种琥珀酸脱氢酶 (succinate dehydrogenase) 抑制剂，主要通过干扰真菌的能量代谢与生长，对Rhizoctonia solani、Sclerotinia sclerotiorum、Botrytis cinerea 和 Fusarium graminearum 展示抑制效能，EC50< 0.3 μg mL。

Succinate dehydrogenase-IN-7 (Compound 2f) 是琥珀酸脱氢酶抑制剂 (IC50= 2.51 μM)，并且具有杀菌活性。

Succinate dehydrogenase-IN-6 (Compound E23) 是一种琥珀酸脱氢酶 (SDH) 抑制剂，在立枯丝核菌 (Rhizoctonia solani) 中的IC50为11.76 μM。它能够破坏真菌细胞膜，展现广谱抗真菌活性，可抑制R. solani、V. dahliae、A. solani和C. gloeosporioides，EC50分别为0.41、0.27、1.15和0.27 μg mL。在水稻和斑马鱼中没有明显毒性表现 (LC50> 12.5 μg mL)。

Frovatriptan Succinate is a synthetic triptan with 5-HT1B 1D receptors agonist activity. It is indicated for the acute treatment of migraine.

L-703,664 succinate is a 5-HT1D receptor agonist.

Rabacfosadine succinate is the acyclic nucleoside phosphonate PMEG double prodrug.

MP-10 succinate is a potent and specific inhibitor of PDE10A.

Ereboxetine succinate, a selective norepinephrine reuptake inhibitor, is an even more selective (+)-(S, S)- enantiomer of reboxetine. It is currently being developed for the treatment of neuropathic pain and fibromyalgia.

PQ1 Succinate, a gap junction enhancer, acts by restoring GJIC and increasing connexin expression in breast cancer cell lines while not affecting normal mammary cells.

Ibiglustat (Venglustat) succinate is an orally active, brain-penetrant inhibitor of glucosylceramide synthase (GCS). It is utilized in the investigation of Gaucher disease type 3, Parkinson's disease associated with GBA mutations, Fabry disease, GM2 gangliosidosis, and autosomal dominant polycystic kidney disease.

Batefenterol Succinate is a first-in-class inhaled bifunctional bronchodilator possessing muscarinic receptor antagonist and β2-adrenoceptor agonist properties.

Dexamethasone sodium succinate is the acetate salt form of dexamethasone, which is a synthetic glucocorticoid; it combines high anti-inflammatory effects with low mineralocorticoid activity. At high doses (e.g. 40 mg), it reduces the immune response. Dexamethasone acetate (NEOFORDEX®) is indicated in adults for the treatment of symptomatic multiple myeloma in combination with other medicinal products. Dexamethasone has been shown to induce multiple myeloma cell death (apoptosis) via a down-regulation of nuclear factor-κB activity and an activation of caspase-9 through second mitochondria-derived activator of caspase (Smac; an apoptosis promoting factor) release. Prolonged exposure was required to achieve maximum levels of apoptotic markers along with increased caspase-3 activation and DNA fragmentation. Dexamethasone also down-regulated anti apoptotic genes and increased IκB-alpha protein levels. Dexamethasone apoptotic activity is enhanced by the combination with thalidomide......

Pemrametostat succinate is an orally active, potent and selective inhibitor of protein arginine methyltransferase 5 (PRMT5) that potently inhibits tumor growth in vitro and in vivo in animal models.

HDM-201 succinate is an orally bioavailable human double minute 2 homolog (HDM2) inhibitor with potential antineoplastic activity.

Nemiralisib succinate is a potent and selective PI3Kδ inhibitor.

Carsatrin succinate is the salt form of Carsatin, a purinylpiperazine derivative used as a cardiotonic and antiarrhythmic. Carsatrin acts as positive inotropic agent that increases twitch tension and prolongs the action potential (AP) duration of ventricular muscle without affecting the Na+, K+-ATPase, adenylyl cyclase, phosphodiesterase isozymes, or cardiac myofilaments. Carsatrin’s positive inotropic effect can be prevented by tetrodotoxin but not by the adrenergic antagonists timolol, yohimbine, or prazosin.

Fluoxetine succinate ester is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class. It is used for the treatment of major depressive disorder, obsessive–compulsive disorder, bulimia nervosa, panic disorder, and premenstrual dysphoric disorder.