pancreatic lipase

Gypsogenin-3-O-glucuronide (Methyl gypsogenin 3-O-beta-D-glucuronopy) 是一种皂角苷前体，普遍存在于满天星属植物中。

hPL-IN-1 是一种有效的可逆胰脂肪酶 (PL) 抑制剂 (IC50=1.86 μM)，可用于研究与肥胖相关的疾病。

hPL-IN-2 是一种具有有效性、可逆性、和非竞争性胰脂肪酶 (Pancreatic lipase) 抑制剂 (IC50: 1.63 μM)，可用于研究肥胖相关疾病。

3,4,5-Trihydroxycinnamic acid decyl ester 是一种胰腺脂肪酶抑制剂，具有抗癌活性，可诱导细胞凋亡。3,4,5-Trihydroxycinnamic acid decyl ester 具有抗肥胖作用，抑制脂质吸收和积累，可用于研究乳腺癌和前列腺癌。

Pancreatic lipase Carboxylesterase 1-IN-1 (Compound 39) 是一种有效的、双重的胰脂酶 (PL) 和人羧酸酯酶 1A (hCES1A) 抑制剂，作用于 PL (IC50: 2.13 μM) 和 hCES1A (IC50: 0.055 μM)。

Oleic acid (Glycon Wo) 属于天然产物，是一种常见的不饱和脂肪酸，在存在于多种动物、植物的脂肪和油脂中。Oleic acid 是一种 Na+ K+ATP 酶激活剂。

Phloracetophenone (1-(2,4,6-Trihydroxyphenyl)ethanone) 是多叶姜黄中苯乙酮糖苷的糖苷配基部分，具有抗肥胖，降血脂和降低胆固醇作用，能够增强胆固醇 7α-羟化酶的活性。

Orlistat (Tetrahydrolipstatin) 是一种脂肪酶 (lipase) 抑制剂，也是一种脂肪酸合成酶 (FASN) 抑制剂。Orlistat 具有促减肥的作用。

Sanggenon C 是一种从桑属的根皮中分离得到的黄烷酮 Diels-Alder 加合物化合物。Sanggenon C 可抑制NF-κB 活性，抑制 RAW264.7 细胞中诱导型一氧化氮合酶的表达，以及肿瘤坏死因子-α 刺激的细胞粘附和血管细胞粘附分子-1 的表达； Sanggenon C 还具有抗氧化和抗炎作用，也有抑制胰脂肪酶作用。[1,2]

Cetilistat (ATL-962) 是胰腺脂肪酶 (pancreatic lipase) 抑制剂，能够抑制大鼠脂肪酶(IC50:54.8 nM)和人胰脂肪酶(IC50:5.95 nM)的活性，可用作有效的抗肥胖药。

4-Nitrophenyl palmitate serves as a colorimetric substrate for lipase and esterase, enabling the quantification of enzyme activity through the release and colorimetric detection of 4-nitrophenol at 410 nm following enzymatic hydrolysis. This compound facilitates the characterization of enzyme activity across diverse bacterial and mammalian sources, including Burkholderia and porcine pancreatic lipases.

Morachalcone A displays significant tyrosinase inhibitory activity (IC50, 0.013 uM); it also exerts strong pancreatic lipase inhibition with IC 50 value of 6.2 uM. Morachalcone A exhibits neuroprotective effects on HT22-immortalized hippocampal cells agai

Escin IB 是一种皂苷，分离自马栗子种子的皮和胚乳中，能够抑制 pancreatic lipase 的活性。

1,2-Dioleoyl-3-behenoylglycerol (BOO) 能够有效抑制胰腺脂肪酶的活性，并防止内脏脂肪与肝脏三酰甘油 (TAG) 的积累。

Orlistat-d3 is intended for use as an internal standard for the quantification of orlistat by GC- or LC-MS. Orlistat is a digestive lipase inhibitor. It inhibits diacylglycerol lipase α (DAGLα), DAGLβ, α β-hydrolase domain-containing protein 12 (ABHD12), ABHD16A, and platelet-activating factor acetylhydrolase (PAF-AH; IC50s = 0.06, 0.1, 0.08, 0.03, and 0.05 µM, respectively), as well as pancreatic lipase and hormone-sensitive lipase (IC50s = 0.65 and 2.1 µg ml, respectively) but does not inhibit fatty acid amide hydrolase (FAAH) or KIAA1363 (IC50s = >100 µM for both). Orlistat decreases ionomycin-induced production of the endocannabinoid 2-arachidonoyl glycerol (2-AG) in N18TG2 murine neuroblastoma cells when used at a concentration of 1 µM. It also inhibits fatty acid synthase (FASN; Kiapp = ~0.1 µM for the human enzyme) and the proliferation of PC3 prostate cancer cells in a concentration-dependent manner. Orlistat (10 mg kg) decreases serum cholesterol levels and total bod......

Peonidin-3-O-arabinoside chloride (Compound Ⅻ) 是一种从蔓越莓果实中分离得到的花青素，是胰脂肪酶抑制剂，是一种膳食补充剂，可用于研究肥胖。

2,6,4'-Trihydroxy-4-methoxybenzophenone shows weak inhibitory activity of testosterone 5alpha-reductase, it also shows significant inhibition of pancreatic lipase activity. 2,6,4'-Trihydroxy-4-methoxybenzophenone has neurotrophic activity, it induced neurite outgrowth in PC-12 cells at concentration of 50 microg/ml. 2,6,4′-Trihydroxy-4-methoxybenzophenone exhibits low cytotoxic effect against HeLa and 3T3 cell lines with IC50 values of 132 ug/ml and 158 ug/ml, repectively. It also shows antioxidant activity on DPPH with IC50 of 10.57 ug/mL.

Echitamine chloride 是存在于 Alstonia scholaris 中的主要单萜吲哚生物碱，具有有效的抗肿瘤活性。Echitamine chloride 会诱导 DNA 片段化和细胞凋亡 (apoptosis)。Echitamine chloride 抑制胰腺脂肪酶 (pancreatic lipase)，IC50为 10.92 µM。

1,2-Dilaurin 是一种二酰基甘油，在 sn-1 和 sn-2 位置含有月桂酸。它被用作定量大鼠脱鞘坐骨神经中甘油二酯的内标。含有 1,2-二月桂酰-rac-甘油的单分子膜可用作底物来测量表面压力，以及研究胰原辅脂肪酶和辅脂肪酶对猪胰脂肪酶活性的影响。

3-O-Methylgalangin (GALANGIN-3-METHYLETHER) 是一种来源于高良姜根茎的天然黄酮，具有抗菌活性，抑制胰腺脂肪酶。

Crocin II (Crocetin gentiobiosylglucosyl ester) 是从栀子果实中分离出来的一种天然产物，具有抗氧化、抗癌和抗抑郁活性。它抑制 iNOS 和 COX-2的蛋白质和 m-RNA 的表达，还抑制NO 产生，IC50值为 31.1 μM。

GNN14490, a substrate for human pancreatic lipase, is utilized to create monomolecular films for enzyme assay studies.

Cetilistat impurity 1 is an impurity of Cetilistat, which is an inhibitor of pancreatic lipase. It inhibits rat and human pancreatic lipase activity with IC50s of 54.8 nM and 5.95 nM, respectively.

Benastatin C is a polyketide synthase-derived benastatin that has been found inStreptomycesand has diverse biological activities.1,2It inhibits glutathione S-transferase (GST; IC50= 24 μg ml for the rat liver enzyme).2Benastatin C also inhibits the esterase activity of isolated porcine pancreatic lipase (IC50= 10 μg ml). It increases LPS- or concanavalin A-induced blastogenesis of isolated mouse spleen lymphocytes in a concentration-dependent manner. 1.Xu, Z., Schenk, A., and Hertweck, C.Molecular analysis of the benastatin biosynthetic pathway and genetic engineering of altered fatty acid-polyketide hybridsJ. Am. Chem. Soc.129(18)6022-6030(2007) 2.Aoyama, T., Kojima, F., Yamazaki, T., et al.Benastatins C and D, new inhibitors of glutathione S-transferase, produced by Streptomyces sp. MI384-DF12. Production, isolation, structure determination and biological activitiesJ. Antibiot. (Tokyo)46(5)712-718(1993)