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Search Results for " outgrowth "

33

抑制剂 & 化合物

24

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T8869	B355252	Others	Others
	B355252 是苯氧基噻吩磺酰胺小分子，NGF 受体激动剂。它能增强 NGF 诱导的神经突生长。它可减轻 DNA 损伤、抑制 ROS 生成、降低 LDH 水平以及预防神经元凋亡，保护缺血性神经元免受神经元损失。它具有抗细胞凋亡作用。
T2306	Brexpiprazole 依匹哌唑,OPC-34712,依匹唑派	Dopamine Receptor; 5-HT Receptor; Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Brexpiprazole (OPC-34712) 是人5-HT1A 和多巴胺受体的部分激动剂，Ki 分别为0.12 和 0.3 nM。它也是5-HT2A 受体的拮抗剂，Ki 为 0.47 nM，可作为非典型抗精神病药。
T8690	Brexpiprazole HCl OPC 34712 dihydrochloride	Others	Others
	Brexpiprazole HCl (OPC 34712 dihydrochloride) 是一种新型抗精神病药物。
T32658L	Leteprinim AIT082 acid,AIT 082 acid,AIT-082 acid	Others	Others
	Leteprinim (AIT 082 acid) 是一种次黄嘌呤衍生物，可刺激体外神经突生长和星形胶质细胞产生腺苷和神经营养因子。
T16518	PH-002	Others	Others
	PH-002 是一种抑制载脂蛋白 E4 神经内分子相互作用的抑制剂(IC50:116 nM)。
T4431	Olodanrigan PD-126055,EMA401	RAAS	Endocrinology/Hormones
	Olodanrigan (EMA401) 是具有口服活性、高选择性及外周受限的血管紧张素 Ⅱ 类型 2 受体(AT2R)拮抗剂。它的缓解疼痛的机制可能是：抑制增强的 AngII/AT2R 诱导的 p38 和 p42/p44 MAPK 激活，进而阻碍 DRG 神经元的过度兴奋性及 DRG 神经元的萌发。它可用于研究神经性疼痛。
T32541	Lalioside
	Lalioside is a potent accelerator of neurite outgrowth.
T29209	ZD4190 HCl ZD-4190,ZD-4190 HCl,ZD 4190,ZD4190,ZD-4190 hydrochloride
	ZD-4190, a potent VEGFR inhibitor, prevents tumour outgrowth in a model of minimal residual carcinoma in deep tissues.
T26050	RC-33 HCl RC 33 Hydrochloride,RC-33 Hydrochloride,RC33 Hydrochloride
	RC-33 HCl is a selective and metabolically stable σ1 receptor agonist potentiating NGF-induced neurite outgrowth.
T34778	Talaumidin
	Talaumidin is a natural neurotrophic agent which promotes neurite outgrowth from neurons through the PI3K/Akt pathway.
T0811L	Amisulpride hydrochloride APD-421,Amisulpride HCl,APD 421,APD421,Sultopride,氨磺必利盐酸盐
	Amisulpride is an antagonist of 5-HT7 receptor and dopamine D2 and D3 receptors. It modulates beta 2- arresting signaling and increases neurite outgrowth.
T70647	CD2019
	CD2019 is a retinoic acid receptor beta (rarbeta) agonist, overcoming inhibition of axonal outgrowth via phosphoinositide 3-kinase signalling in the injured adult spinal cord.
T29598	Acetylcarnitine arginyl amide ST-857,acetyl-L-carnitine arginine amide
	Acetylcarnitine arginyl amide is able to stimulate neurite outgrowth in a manner similar to that elicited by nerve growth factor (NGF). Neurite induction by this molecule requires de novo mRNA synthesis and is independent of the action of several common t
TP2074	BigLEN(rat) BigLEN (rat)
	Potent GPR171 agonist (EC50 = 1.6 nM). ProSAAS-derived peptide. Regulates body weight in mice and promotes the outgrowth of neurites in Neuro2A cells.
T29543	ACAF4 ACAF-4,ACAF 4
	ACAF4 is a neurotrophic agent which significantly increases survival in PC12 neuronal cells and enhances the effect of nerve growth factor (NGF). ACAF4 induces neurite outgrowth, and modulates ERK1/2 and AKT signaling pathways.
TP1989	NEP(1-40) Nogo-66 (1-40)
	Peptide fragment corresponding to residues 1 - 40 of Nogo-66, the domain of the myelin protein Nogo that inhibits axonal outgrowth. Acts as a competitive antagonist at the Nogo-66 receptor (NgR); blocks Nogo-66- and CNS myelin-induced inhibition of axonal
T75410	Ganglioside sialidase (AuSialidase S)
	Ganglioside sialidase (AuSialidase S)为一种内源性代谢物，与神经元分化过程有关，涉及神经突生长。
T81580	Ozanezumab GSK1223249
	Ozanezumab (GSK1223249) 是一种anti-Nogo-A 单克隆抗体，用于肌萎缩侧索硬化症 (ALS) 及多发性硬化症研究。
T37476	Cyclo(L-Phe-L-Val)
	Cyclo(L-Phe-L-Val) is a metabolite of the sponge bacterium Pseudoalteromonas sp. NJ6-3-1 that can autoinduce production of antibacterial substances active against S. aureus when co-cultured at a low cell density. It induces neurite outgrowth and branching of chick cortical neurons in vitro when used at concentrations of 16 and 32 μM. It increases phosphorylation of the PI3K substrate Akt, and neurite outgrowth induced by cyclo(L-Phe-L-Val) can be blocked by the PI3K inhibitor LY294002 . Cyclo(L-...
T76539	Insulin-like growth factor II
	Insulin-like growth factor II (IGF-2)为人血清中主要生长激素，对神经突生长具有许可性和直接作用，同时增强交感与感觉神经元的生存能力。
T81576	PA22-2 IKVAV sequence,Laminin A-chain fragment
	PA22-2（IKVAV序列；层粘连蛋白A链片段）为一生物活性肽，源于小鼠层粘连蛋白a1氨基酸2110至2127残基。构成的细胞外基质能够促进神经突生长。
T81575	PA22-2 free acid Cys-Laminin A chain 2091-2108
	PA22-2 (free acid) (Cys-Laminin A chain 2091-2108) 为促进神经突生长和神经元样过程形成的多肽。该化合物适用于人腺样囊性癌细胞培养和肽功能化磷脂双层制备<sup>[3]。
T62046	HDAC6-IN-5
	HDAC6-IN-5 (化合物 11b) 是有效的、血脑屏障通透性的 HDAC6抑制剂(IC50= 0.025 μM)。HDAC6-IN-5 抑制 AChE 活性和 Aβ1-42自聚集和，IC50分别为 0.88 和 1.1 μM。HDAC6-IN-5 能够促进神经突起生长，且无明显神经毒性。
T22529	6-Bnz-cAMP sodium salt	Others	Others
	6-Bnz-cAMP is a PKA-selective activator. It regulates the PKA dependent signaling pathways. The proliferative signaling pathway which activated by the 6-Bnz-cAMP involves activation of the epidermal growth factor receptor and ERK1/2. Extending the duratio
T72162	HIV-1 integrase inhibitor 10
	HIV-1integrase inhibitor 10 是一种 HIV-1变构整合酶抑制剂 (ALLINI)，具有口服活性。HIV-1integrase inhibitor 10 可抑制 NLRepRluc 病毒在 MT-2 细胞中的生长，其 EC50值为 3-5 nM。HIV-1integrase inhibitor 10 可用于人类免疫缺陷病毒-1 (HIV-1) 的研究。
T76583	H-Ile-Lys-Val-Ala-Val-OH
	H-Ile-Lys-Val-Ala-Val-OH 是层纤蛋白-1 有效的活性位点之一。H-Ile-Lys-Val-Ala-Val-OH 可促进细胞粘附、神经突生长和肿瘤生长。H-Ile-Lys-Val-Ala-Val-OH 通过激活 MAPK/ERK1/2和 PI3K/Akt 信号通路，刺激 BMMSC 细胞生长和增殖。
T35436	(-)-L-threo-PDMP (hydrochloride)
	(-)-L-threo-PDMP is an enhancer of ganglioside biosynthesis. The (-)-L-threo-PDMP (1S,2S) isomer is the active stimulatory component of DL-threo-PDMP in contrast to (+)-D-threo-PDMP , which is an inhibitor of glucosylceramide synthetase. (-)-L-threo-PDMP upregulates GM3, GD3, and GQ1b synthase levels, which are glycosyltransferases involved in ganglioside biosynthesis, and increases ganglioside levels in cells. It increases neurite outgrowth and synapse formation in vitro and improves retention ...
T60954	HDAC6-IN-6
	HDAC6-IN-6 (化合物 6a) 是 HDAC6的有效抑制剂，可以穿透血脑屏障，IC50值为0.025 μM。HDAC6-IN-6 对 AChE 和 Aβ1-42自聚集具有有效的抑制活性，IC50值分别为 0.72 和 3.0 μM。HDAC6-IN-6 可促进神经突起生长而没有显著的神经毒性。
T80420	TAT-NEP1-40 acetate	Apoptosis	Apoptosis
	TAT-NEP1-40 acetate 是促进脑卒中后轴突再生和功能恢复的候选分子。该化合物能够抵御PC12细胞的氧和葡萄糖剥夺(OGD)损伤，并促进神经突生长。它通过抑制神经元凋亡(apoptosis)作用，保护大脑免受缺血再灌注伤害，并能有效传递至大鼠的脑内。
T38213	1-β-D-Glucosylsphingadienine (d18:2 (4E,8E)) 1-β-D-Glucosylsphingadienine (d18:2 (4E,8E))
	1-β-D-Glucosylsphingadienine is a glucosylsphingosine, which are deacetylated lysolipid derivatives of glucosylcerebrosides . They are formed when sphingosines undergo glucosidation by UDP-glucose. Glucosylsphingosines completely reduce neurite outgrowth and induce death of LA-N-2 cells at concentrations of 10 and 50 μM, respectively. They also decrease the activity of glucocerebrosidase in LA-N-2 cells in a dose-dependent manner. Glucosylsphingosine levels are elevated in patients with Gaucher'...
T80419	TAT-NEP1-40 TFA	Apoptosis	Apoptosis
	TAT-NEP1-40 TFA 是一种能够穿透血脑屏障的多肽。它能够保护 PC12 细胞抵御缺氧和葡萄糖剥夺 (OGD) 的损害，并促进神经突的生长。此外，TAT-NEP1-40 TFA 可通过减少缺血性脑损伤中的细胞凋亡，以改善神经系统功能。该化合物在中枢神经系统损伤，包括中风后轴突再生及功能恢复的研究中具有潜在应用价值。
T80418	TAT-NEP1-40	Apoptosis	Apoptosis
	TAT-NEP1-40是一种能够穿透血脑屏障的多肽。它能够保护PC12细胞不受缺氧和葡萄糖剥夺(OGD)所致的损伤，同时促进神经突的生长。此外，TAT-NEP1-40通过阻断缺血性脑损伤中的细胞凋亡，对缺血后的神经功能恢复具有积极作用。该化合物适用于中枢神经系统损伤，特别是中风后的轴突再生与功能恢复方面的研究。
T37582	Ganglioside GM1 Mixture (ovine) (ammonium salt)
	Ganglioside GM1is a monosialylated ganglioside and the prototypic ganglioside for those containing one sialic acid residue.1,2It is found in a large variety of cells, including immune cells and neurons, and is enriched in lipid rafts in the cell membrane.3It associates with growth factor receptors, including TrkA, TrkB, and the GDNF receptor complex containing Ret and GFRα, and is required for TrkA expression on the cell surface. Ganglioside GM1interacts with other proteins to increase calcium i...

化合物

Cat.No: T8869

Target: Others

Cat.No: T2306

Synonym: 依匹哌唑,OPC-34712,依匹唑派

Target: Dopamine Receptor, 5-HT Receptor, Adrenergic Receptor

Brexpiprazole HCl

Cat.No: T8690

Synonym: OPC 34712 dihydrochloride

Target: Others

Cat.No: T32658L

Synonym: AIT082 acid,AIT 082 acid,AIT-082 acid

Target: Others

Cat.No: T16518

Target: Others

Cat.No: T4431

Synonym: PD-126055,EMA401

Target: RAAS

Cat.No: T32541

Cat.No: T29209

Synonym: ZD-4190,ZD-4190 HCl,ZD 4190,ZD4190,ZD-4190 hydrochloride

Cat.No: T26050

Synonym: RC 33 Hydrochloride,RC-33 Hydrochloride,RC33 Hydrochloride

Cat.No: T34778

Amisulpride hydrochloride

Cat.No: T0811L

Synonym: APD-421,Amisulpride HCl,APD 421,APD421,Sultopride,氨磺必利盐酸盐

Cat.No: T70647

Acetylcarnitine arginyl amide

Cat.No: T29598

Synonym: ST-857,acetyl-L-carnitine arginine amide

Cat.No: TP2074

Synonym: BigLEN (rat)

Cat.No: T29543

Synonym: ACAF-4,ACAF 4

Cat.No: TP1989

Synonym: Nogo-66 (1-40)

Ganglioside sialidase (AuSialidase S)

Cat.No: T75410

Cat.No: T81580

Synonym: GSK1223249

Cyclo(L-Phe-L-Val)

Cat.No: T37476

Insulin-like growth factor II

Cat.No: T76539

Cat.No: T81576

Synonym: IKVAV sequence,Laminin A-chain fragment

PA22-2 free acid

Cat.No: T81575

Synonym: Cys-Laminin A chain 2091-2108

Cat.No: T62046

6-Bnz-cAMP sodium salt

Cat.No: T22529

Target: Others

HIV-1 integrase inhibitor 10

Cat.No: T72162

H-Ile-Lys-Val-Ala-Val-OH

Cat.No: T76583

(-)-L-threo-PDMP (hydrochloride)

Cat.No: T35436

Cat.No: T60954

TAT-NEP1-40 acetate

Cat.No: T80420

Target: Apoptosis

1-β-D-Glucosylsphingadienine (d18:2 (4E,8E))

Cat.No: T38213

Synonym: 1-β-D-Glucosylsphingadienine (d18:2 (4E,8E))

TAT-NEP1-40 TFA

Cat.No: T80419

Target: Apoptosis

Cat.No: T80418

Target: Apoptosis

Ganglioside GM1 Mixture (ovine) (ammonium salt)

Cat.No: T37582

Cat. No.	Product Name	Target	Signaling Pathways
T6S1740	Nardosinone 苷松新酮,甘松新酮	Others	Others
	Nardosinone 是一个 dbcAMP 和 staurosporine 的神经生成作用增强剂，分离自Nardostachys chinensis 中。Nardosinone 可能成为一种有用的药理学工具，不仅可用于研究神经生长因子 (NGF) 的作用机理，而且可用于研究神经毒性物质的作用机理。
TQ0218	Deoxyandrographolide 去氧穿心莲内酯,14-deoxyandrographolide	IL Receptor; TNF	Apoptosis; Immunology/Inflammation
	Deoxyandrographolide (14-deoxyandrographolide) 抑制 LPS 诱导的 iNOS mRNA 水平升高以及促炎症介质 TNF-α 和 IL-6 的产生。它增强 NGF 诱导的神经突起生长。
T2S0843	Negletein 黄芩素-7-甲醚,7-O-Methylbaicalein,Baicalein-7-methylether	IL Receptor; TNF; NOS; Interleukin	Apoptosis; Immunology/Inflammation
	Negletein (7-O-Methylbaicalein) 一种神经保护剂，可增强神经生长因子的作用并诱导 PC12 细胞中的神经突生长。它通过抑制TNF-α和IL-1β表现出抗炎活性，其 IC50值分别为 16.4 和 10.8 μM。它还具有抗菌、抗缺氧和抗阿尔茨海默病活性。
T3836	Eudesmin	MAPK; S6 Kinase	MAPK; PI3K/Akt/mTOR signaling
	Eudesmin 通过抑制S6K1信号通路来干扰成脂分化，具有抗肿瘤、抗炎和抗菌活性。
T3S1589	Notoginsenoside Fa	Others	Others
	Notoginsenoside Fa 是一种原人参二醇型皂苷，从P. notoginseng 提取出来得到，有激活和恢复退化脑功能的潜能。
T2S0531	Pinoresinol dimethyl ether (+)-Eudesmin,松脂素二甲醚	Others; PKC	Chromatin/Epigenetic; Cytoskeletal Signaling; Others
	Pinoresinol dimethyl ether 是一种非酚性呋喃木质素，从 Magnolia kobus 茎皮中分离得到，具有神经活性。它可刺激上游 MAPK、PKC 和 PKA 通路，诱导 PC12 细胞神经突起生长。
TN1038	Galgravin	Apoptosis	Apoptosis
	Galgravin 是望春花中的一种天然产物，具有抗炎和体外细胞毒活性，能诱导白血病细胞凋亡。
T2787	Picroside I 6'-Cinnamoylcatalpol,胡黄连苦苷I	MMP; STAT	JAK/STAT signaling; Proteases/Proteasome; Stem Cells
	Picroside I (6'-Cinnamoylcatalpol) 是胡黄连的一种天然产物，是有肝脏保护作用的代谢成分，可用于哮喘研究，有减轻炎症作用，还下调 pSTAT6 和 GATA3 表达。
TN2844	(2R,3S)-Dihydrodehydroconiferyl alcohol	MAPK; PKC	Chromatin/Epigenetic; Cytoskeletal Signaling; MAPK
	(2R,3S)-Dihydrodehydroconiferyl alcohol can induce neurite outgrowth and enhance NGF-induced neurite outgrowth from PC12 cells by amplifying up-stream steps such as MAPK and PKC.
TN4127	Gentiside J	Others	Others
	Gentiside J is a potent inducer of neurite outgrowth on PC12 cells.
T82444	Erinacine U
	Erinacine U, a cyanhydrin diterpene isolated from Hericium erinaceus, exhibits neurotrophic activity and notably promotes neurite outgrowth in PC12 cells.
TN4981	Secologanin dimethyl acetal 金银花	Others	Others
	Secologanin dimethyl acetal induces significant neurite outgrowth.
TN4651	Neuchromenin	Others	Others
	(-)-Neuchromenin is an inducer of neurite outgrowth of PC12 cells at concentration of 2.5-10 ug/ml.
T81213	Sarbronine M
	Scabronine M为新型NGF诱导的PC12细胞突起生长抑制剂。
TN2995	4,10-Aromadendranediol	ERK; GSK-3; Wnt/beta-catenin	Cytoskeletal Signaling; MAPK; PI3K/Akt/mTOR signaling; Stem Cells
	4,10-Aromadendranediol exhibits neurite outgrowth-inducing activity in neurons via activation of the ERK signaling pathway, which may be beneficial to the treatment of brain diseases.
T15702	Lactacystin	Proteasome	Proteases/Proteasome; Ubiquitination
	Lactacystin is an antibiotic Streptomyces spp. the metabolite and is an effective and selective proteasome inhibitor (IC50: 4.8 μM for 20S proteasome). Lactacystin inhibits cell growth and induces neurite outgrowth and also inhibits the lysosomal enzyme cathepsin A.
TN4126	Gentiside B	Others	Others
	Gentiside B is a potent inducer of neurite outgrowth on PC12 cells, it shows a significant neuritogenic activity at 30 microM against PC12 cells that is comparable to that seen for the best nerve growth factor (NGF) concentration of 40 ng/mL.
TMA0984	Cerevisterol	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Cerevisterol 是一种细胞毒性类固醇，提取于Agaricus blazei 子实体，对 DNA 聚合酶 α 的活性具有抑制作用。
TN5655	Broussonin B
	Broussonins A and B, new phytoalexins from diseased paper mulberry. Broussonin B can induce neurite outgrowth in PC-12 cells at concentration of 50 microg/ml, and show moderate inhibitory activities against a chymotrypsin-like activity of the proteasome.B
T81980	Kissoone C
	Kissoone C (compound 3)，一种三环倍半萜类，源自缬草根提取。该化合物能增强PC12D细胞中神经生长因子(NGF)介导的神经突生长活性。
T81676	NG-012
	NG-012为一种神经生长因子(NGF)增强剂，来源于Penicillium verruculosum F-4542的培养液。该化合物能在大鼠嗜铬细胞瘤细胞系(PC12)中提升NGF引导的神经突生长效应。
TN4286	Isodunnianol	NOS; NF-κB; ROS; AChR	Immunology/Inflammation; Neuroscience; NF-κB
	Isodunnianol exhibits anti-AChE activity with an IC50 value of 13.0 uM; it also exhibits neurite outgrowth-promoting activity at the concentration ranging from 0.1 to 10 uM in the primary cultured rat cortical neurons. Isodunnianol, dunnianol, and Macrant
TN5682	2,6,4'-Trihydroxy-4-methoxybenzophenone
	2,6,4'-Trihydroxy-4-methoxybenzophenone shows weak inhibitory activity of testosterone 5alpha-reductase, it also shows significant inhibition of pancreatic lipase activity. 2,6,4'-Trihydroxy-4-methoxybenzophenone has neurotrophic activity, it induced neurite outgrowth in PC-12 cells at concentration of 50 microg/ml. 2,6,4â²-Trihydroxy-4-methoxybenzophenone exhibits low cytotoxic effect against HeLa and 3T3 cell lines with IC50 values of 132 ug/ml and 158 ug/ml, repectively. It also shows antiox...
TN2626	14-Norpseurotin A	Antifection	Microbiology/Virology
	14-Norpseurotin A shows good antileishmanial and moderate anticancer activities. It also displays significant antimicrobial activities against Escherichia coli, Bacillus subtilis, and Micrococcus lysoleikticus with MICs of 3.74, 14.97, and 7.49 microM , r

天然产物

Cat.No: T6S1740

Synonym: 苷松新酮,甘松新酮

Target: Others

Deoxyandrographolide

Cat.No: TQ0218

Synonym: 去氧穿心莲内酯,14-deoxyandrographolide

Target: IL Receptor, TNF

Cat.No: T2S0843

Synonym: 黄芩素-7-甲醚,7-O-Methylbaicalein,Baicalein-7-methylether

Target: IL Receptor, TNF, NOS, Interleukin

Cat.No: T3836

Target: MAPK, S6 Kinase

Notoginsenoside Fa

Cat.No: T3S1589

Target: Others

Pinoresinol dimethyl ether

Cat.No: T2S0531

Synonym: (+)-Eudesmin,松脂素二甲醚

Target: Others, PKC

Cat.No: TN1038

Target: Apoptosis

Cat.No: T2787

Synonym: 6'-Cinnamoylcatalpol,胡黄连苦苷I

Target: MMP, STAT

(2R,3S)-Dihydrodehydroconiferyl alcohol

Cat.No: TN2844

Target: MAPK, PKC

Cat.No: TN4127

Target: Others

Cat.No: T82444

Secologanin dimethyl acetal

Cat.No: TN4981

Synonym: 金银花

Target: Others

Cat.No: TN4651

Target: Others

Cat.No: T81213

4,10-Aromadendranediol

Cat.No: TN2995

Target: ERK, GSK-3, Wnt/beta-catenin

Cat.No: T15702

Target: Proteasome

Cat.No: TN4126

Target: Others

Cat.No: TMA0984

Target: DNA/RNA Synthesis

Cat.No: TN5655

Cat.No: T81980

Cat.No: T81676

Cat.No: TN4286

Target: NOS, NF-κB, ROS, AChR

2,6,4'-Trihydroxy-4-methoxybenzophenone

Cat.No: TN5682

14-Norpseurotin A

Cat.No: TN2626

Target: Antifection

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