lysine-acetylated

GW841819X is an analogue of (+)-JQ1 and a novel inhibitor of BET bromodomains. GW841819X was a single enantiomer but of undefined chirality at the 4-position of the benzodiazepine ring3. GW841819X and JQ1 were recently discovered that bind to the acetyl-lysine binding pocket of BET bromodomains with Kd ranges from 50 to 370 nM [1]. GW841819X bounded to both the individual BD1 and BD2 domains with affinities of 46 and 52.5 nM, respectively. GW841819X-Brd3 interaction was estimated to be around 70 nM4. GW841819X displayed activity in vivo against NUT-midline carcinoma, multiple myeloma, mixed-lineage leukemia, and acute myeloid leukemia1. It also potent induced the ApoA1 reporter gene with an EC50 of 440 nM. It had very little effect on LDL-R luciferase activity at the concentrations at which it induces ApoA1 expression, suggesting that the effect is indeed specific3. GW841819X competed directly with GATA1 site for BD1 binding and also specifically blocked the interaction between Brd3 and acetylated GATA14. Recent findings reported that GW841819X are chose as an interest compound to further develop into potential drugs against diseases including cancer, HIV infection and heart disease2.

Mivebresib (ABBV-075) 是一种有效的，口服活性的溴结构域和末端结构域 (BET) 抑制剂，结合BRD4的Ki 值是 1.5 nM。

Acetyl-L-lysine (Nα-Acetyl-L-lysine) 是一种 N-乙酰化氨基酸。它是人类尿液中的一种正常成分，在正常样本中的浓度太小，无法进行常规检测;然而，在一名氨基酰化酶I缺乏症患者的尿液中发现其水平升高。

FT-1101 is an orally bioavailable, potent and selective BET inhibitor. FT-1101 binds to the acetylated lysine recognition motifs in the bromodomain sites of BET proteins, thereby preventing the interaction between the BET proteins and acetylated histones. This disrupts chromatin remodeling and gene expression. Prevention of the expression of certain growth-promoting genes may lead to the inhibition of tumor cell growth. BET proteins, comprised of BRD2, BRD3, BRD4 and BRDT, are transcriptional regulators that play an important role during development and cellular growth.

AURKA against 1(compound Ac13) 作为针对Aurora激酶(AURKA)的抑制剂，其IC50值低于0.5 nM，专门靶向K162位点的内源性赖氨酸乙酰化，并展示了阻断肿瘤细胞增殖的能力。在HCT116细胞中转染了SIRT3后，AURKA against 1诱导的K162位点乙酰化的AURKA激酶活性能够被逆转。

Bovine Serum Albumin, Acetylated (Ac-BSA) 是一种具有已知结构的多肽，具有强抗原性，用于验证实验方法的准确性和可靠性。Ac-BSA 可在 ELISA 或 WB 实验中作为阳性对照，特别是在乙酰化赖氨酸单克隆或多克隆抗体实验中应用。此外，Bovine Serum Albumin, Acetylated 有助于提高低浓度 PLGA 的包封效率，而 PLGA 是一种生物相容性、降解性和控释特性的药物递送聚合物。